European Journal of Immunology

T cell receptor engagement induces coordinated actin and microtubule cytoskeletal remodeling at the immunological synapse. This dynamic reorganization generates mechanical forces that sustain TCR signaling and promote effective T cell activation. The SSH1–cofilin–LIMK1 signaling pathway plays a pivotal role in regulating cytoskeletal dynamics during this process. ABSTRACT During T cell immune responses, actin dynamics facilitates … Read more

This study discovered the small molecule 9-methoxy-6-methylindolo[3,2-b] quinoxaline (IFA005) as a potent immunomodulator capable of converting human memory CD4⁺ T cells into functional Foxp3⁺ regulatory T cells. IFA005 suppresses Th2 cytokines (IL-4, IL-5, and IL-13) and promotes the iTreg phenotype by inhibiting Wnt/β-catenin signaling through NKD2 upregulation. These findings support small-molecule-mediated Wnt/β-catenin blockade as a … Read more

Autoantibodies in ulcerative colitis target neutrophil and mucosal components, including NETs, goblet cells, and integrins-offering insight into disease pathophysiology. Understanding these interactions may support biomarker development, enable earlier diagnosis, aid patient stratification, and drive future therapeutic innovation. ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by immune dysregulation and epithelial barrier dysfunction. … Read more

We investigated neutrophil heterogeneity in patients with systemic lupus erythematosus and identified increased surface levels of LAMP1 (CD107a). Stimulation of healthy donor neutrophils led to increased surface LAMP1. Urine and serum soluble LAMP1 levels were increased in patients, especially those with proliferative lupus nephritis. ABSTRACT Lupus nephritis (LN) is a severe manifestation of systemic lupus … Read more

Testosterone suppresses Th17 cell differentiation and alleviates Th17-driven skin inflammation in an experimental psoriasis model. Mechanistically, testosterone binds to the ligand-binding domain (LBD) of RORγt, inhibiting its transcriptional activity required for IL-17 production and other Th17-cell-associated proinflammatory gene expression. These findings provide a mechanistic explanation for testosterone’s immunosuppressive effects and offer insights into the gender … Read more

Blood CD8 T cells in mice with advanced liver fibrosis exhibit IFN-γ and granzyme B hyperfunction, and animal responses to ectopic tumour challenge and immunotherapy are impaired. ABSTRACT Immune dysfunction in liver disease contributes to significant morbidities, depending on liver damage severity and aetiology. We previously reported long-lasting generalized CD8 T cell hyperfunction in chronic … Read more

European Journal of Immunology, Volume 55, Issue 8, August 2025.

• SLAM family receptors regulate the susceptibility of hematopoietic stressed cells to NK cell-mediated cytotoxicity. • Leukemia cells might downregulate the expression of SLAM family receptors to avoid being recognized and lysed by NK cells. • NK cell engagers containing SLAM family receptors may be an important resource for the design of therapeutic strategies aiming … Read more

In N-ERD patients, oral aspirin-induced bronchospasm is associated with increased blood group 1 innate lymphoid cells (ILC1s), decreased sputum eicosanoids, and increased urinary leukotriene E4 (LTE4), suggesting a potential role of blood ILC1s in aspirin-induced bronchoconstriction. ABSTRACT Previous studies confirmed increased group 2 innate lymphoid cell (ILC2s) count in nasal scrapings, alongside a reduced blood … Read more

During filarial nematode infection with Litomosoides sigmodontis, PD-L2 down-regulates Th2 cell expression of GATA-3 and Th2 cytokines and enables parasite survival. Concurrently, B cells suppress protective immunity through a mechanism that does not involve PD-L2. ABSTRACT Filarial nematodes infect over 200 million people, predominantly stimulating a Type 2 immune response. Protective immunity takes decades to … Read more