BackgroundPrimary focal hyperhidrosis (PFH) significantly impacts patients’ physical and mental health, yet its underlying mechanisms remain unclear.MethodsThis study involved 80 healthy controls and 60 patients each with primary palmar (PPH), craniofa…
The gut microbiome critically regulates antitumor immunity through its metabolic byproducts, which serve as pivotal mediators of host-microbe crosstalk in tumor immunotherapy. This review synthesizes cutting-edge evidence on how microbial metabolites—i…
IntroductionImmune cells form defined pro- and anti-inflammatory regions around a pathogen during an innate immune response. These include, in Toll-like receptor (TLR)-2-induced inflammation, a core region containing the pathogen, an adjacent pro-infla…
Psoriasis vulgaris (PV) is a common, T cell mediated dermatosis with substantial systemic footprint. While αβ T cells are well established drivers of PV, the role of γδ T cells, including their abundance, clonal architecture and transcriptional program…
Viral diseases remain a major barrier to the sustainable production of farmed fish, primarily attributable to the absence of effective prevention and treatment options. Understanding host-pathogen interactions can guide the development of vaccines, ant…
With the rapid advancement of nanotechnology, the application of nanomedicine has become increasingly widespread, demonstrating remarkable potential for highly precise targeting and efficacious drug delivery. Compared to conventional drug delivery appr…
Antibody-negative combined central and peripheral demyelination (CCPD) is a rare neuroimmunological disorder with heterogeneous manifestations and variable treatment response. We report a case of a 40-year-old man who developed acute hypercapnic respir…
Advanced endometrial cancer (EC) poses significant therapeutic challenges due to molecular heterogeneity and immune evasion. Immune checkpoint inhibitors (ICIs) show promise, particularly in mismatch repair-deficient (MMRd) and POLE-mutated subtypes, b…
Epithelial ovarian cancer (EOC) remains a lethal epithelial malignancy. Immune-checkpoint inhibitors have entered management for recurrent/metastatic disease; yet durable benefit is confined to a subset, reflecting TGF-β–conditioned stromal barriers an…
