BackgroundLumbar disc degeneration, a primary cause of chronic low back pain, is closely linked to inflammatory responses and the immune microenvironment; however, its underlying mechanisms remain poorly understood.MethodsThis study integrated scRNA-se…
IntroductionCancer survivors display impaired quality of life and increased risk to develop cardiometabolic comorbidities. Low-grade chronic inflammation (LGCI) plays a crucial role in cancer progression and in cardiometabolic diseases. Although the Me…
The intricate interplay between macrophage biology and lipid metabolism has emerged as a critical determinant of metabolic homeostasis, disease progression and pathogenesis. This comprehensive review explores the molecular mechanisms through which fatt…
IntroductionIn systemic sclerosis (SSc), the laboratory panel lacks biomarkers able to predict the disease course and/or reflect the fibrotic activity in the skin and internal organs. We assessed the association of the serum levels of urokinase (urokin…
ObjectiveVEXAS syndrome (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) is a late-onset autoinflammatory disorder caused by somatic mutations in the UBA1 gene. It is characterized by systemic inflammation, a wide spectrum of rheumatologic fe…
Lung cancer is the most prevalent malignant tumor in China, with the highest incidence and mortality rates. Among the various types of lung cancer, non-small cell lung cancer (NSCLC) accounts for approximately 80% to 85%. Radical surgery is the primary…
Chronic obstructive pulmonary disease (COPD) is a prevalent chronic respiratory disease characterized by high prevalence, mortality, and disease burden. Current understanding of COPD pathogenesis primarily focuses on airway inflammation, immune dysfunc…
Pancreatic Acinar Cell Carcinoma (PACC) is a rare subtype of pancreatic cancer, and its systematic treatment protocol is still pending for further exploration. There have been a few reports that PACC patients benefited from immunotherapy-integrated tre…
ObjectiveThis systematic review and meta-analysis aims to characterize the distribution of HIV-1 viral tropism at diagnosis among people living with HIV (PLWH) and examine its association with baseline CD4+ T lymphocyte counts, thereby providing an evi…
Adjuvants enhance immune responses; thereby increasing the efficacy of vaccines and longevity of the immune response. Despite this critical role, discovery of new adjuvants and pipelines to immunologically characterize and produce them at scale remain …
