The circadian system is an important regulator of cardiovascular immune homeostasis. Emerging evidence suggests that daily timing of immune responses may influence cardiovascular disease progression by coordinating leukocyte trafficking, inflammatory t…
Renal ischemia-reperfusion injury (IRI) is a major pathological driver of acute kidney injury (AKI), for which effective therapeutic strategies remain lacking. Recently, novel forms of programmed cell death (PCD), including pyroptosis, ferroptosis, cup…
Cellular senescence constitutes the core biological basis of body aging. It not only directly drives the occurrence and progression of multiple age-related diseases, but also establishes and maintains a chronic inflammatory microenvironment through the…
Macrophage polarization has a significant influence on the immune microenvironment of skeletal muscle, regulating metabolic and repair homeostasis. Meteorin-like protein (Metrnl), a recently identified myokine, is implicated in immunity, metabolism, an…
Graphical AbstractInfographic illustrating three columns: challenges such as thymic involution, cellular senescence, and epigenetic aging; targeted interventions including exercise, gut health, and mind-body therapies; and therapeutic outcomes like imp…
BackgroundThe maintenance of durable humoral immunity against diphtheria, tetanus, and Bordetella pertussis during adolescence is critical for long-term protection and epidemiological stability. However, the immunological impact of booster vaccination …
PRDM1 is a key transcriptional repressor that plays a vital role in B- and T-cell differentiation, immune regulation, and tumor suppression. PRDM1 functions through its C2H2 zinc finger domains and proline-rich region, which mediate transcriptional rep…
Concepts of autoimmune disease have traditionally emphasized genetic susceptibility, antigen-specific immune activation, and inflammation as linear drivers of tissue injury and clinical symptoms. While this framework has been highly successful in expla…
BackgroundT and B cells are central to adaptive immunity, where they identify and neutralize foreign antigens and cancer neo−antigens. Large−scale elucidation of T− and B−cell receptors (TCRs and BCRs) through immune−repertoire sequencing promises nove…
IntroductionTemperature is a key environmental factor regulating physiological, biochemical, and immunological processes in ectothermic fish such as Labeo rohita. Exposure to low-temperature conditions during winter disrupts metabolism, suppresses immu…
