ObjectiveThis report describes the diagnostic and therapeutic management of Sweet’s syndrome (SS) presenting as a painful forehead plaque in a patient with refractory ulcerative colitis (UC) during apparent endoscopic remission. It highlights the assoc…
IntroductionIn thrombi, fibrin formation is accompanied by neutrophil activation, which leads to the release of neutrophil extracellular traps (NETs). Citrullination is a post-translational modification of arginine catalyzed by peptidylarginine deimina…
IntroductionSalmonella and Shigella infections are two of the leading causes of global diarrheal deaths in children younger than 5 years. Licensed vaccines against Salmonella Typhi have been shown to be effective, and other Salmonella and Shigella vacc…
Powassan virus (POWV) is a tick-borne Orthoflavivirus transmitted by Ixodes tick species. POWV causes fatal encephalitis in approximately 10-30% of neurological cases, and long-lasting neurological sequelae in approximately 50% of survivors. POWV entry…
Multiple myeloma (MM) persists within a specialized bone marrow niche in which malignant plasma cells, immune dysfunction, inflammatory signaling, and metabolic stress reinforce one another. To resolve this ecosystem at compartment-level resolution, we…
IntroductionThe resurgence of pertussis poses a severe threat to infants under 3 months of age due to an inherent early-life “immunity gap.” While maternal immunization with the tetanus, diphtheria, and acellular pertussis (Tdap/Tdacp) vaccine effectiv…
BackgroundBenefit from first-line immunotherapy-based treatment in advanced biliary tract cancer (BTC) is heterogeneous, and selection biomarkers are lacking. We investigated whether genomic features could stratify benefit from intensified immunotherap…
Ryanodine receptor 1 (RyR1) is a key intracellular Ca2+ release channel primarily expressed in skeletal muscle, but also in some immune cells. Gain-of-function RYR1 mutations are the most common cause of the pharmacogenetic disorder malignant hyperther…
T cell-directed immunotherapies have transformed the treatment of hematological malignancies, but durable benefit remains limited by relapse, poor persistence, incomplete immune reconstitution and infection. These outcomes depend not only on target-ant…
Epstein-Barr virus-induced gene 3(EBI3) is conventionally viewed as a subunit of IL-27 and IL-35, yet the function of uncomplexed “free” EBI3 is unknown. We show that free EBI3 is an autonomous immunosuppressive cytokine that acts via a gp130/WSX-1/STA…
