Journal of Leukocyte Biology

J Leukoc Biol. 2024 Oct 11:qiae225. doi: 10.1093/jleuko/qiae225. Online ahead of print. ABSTRACT OBJECTIVE: Macrophage activation syndrome (MAS) is characterized by multi-lineage cytopenias, hypercytokinemia, and tissue hemophagocytosis. Transcription factor Nrf2 is a master regulator of redox homeostasis. In this work we aim to investigate the role of Nrf2 in murine hyperinflammation and the mechanisms by … Read more

J Leukoc Biol. 2024 Oct 10:qiae224. doi: 10.1093/jleuko/qiae224. Online ahead of print. ABSTRACT Neutrophils are the innate immune system’s first line of defense, and their storage organelles are essential to their function. The storage organelles are divided into three different granule types named azurophilic, specific, and gelatinase granules, besides a fourth component called secretory vesicles. … Read more

J Leukoc Biol. 2024 Oct 9:qiae222. doi: 10.1093/jleuko/qiae222. Online ahead of print. ABSTRACT The liver has critical digestive, metabolic, and immunosurveillance roles, which get disrupted during liver diseases such as viral hepatitis, fatty liver disease, and hepatocellular carcinoma. While previous research on the pathological development of these diseases has focused on liver-resident immune populations, such … Read more

J Leukoc Biol. 2024 Oct 8:qiae221. doi: 10.1093/jleuko/qiae221. Online ahead of print. ABSTRACT A recent article in Cell reported a new peculiar interaction between mast cells and neutrophils. Upon IgE/Ag-mediated degranulation, mast cells (MCs) produce leukotriene B4 (LTB4), which attracts migrating neutrophils. Some neutrophils are able to establish close contact with MCs and end up … Read more

J Leukoc Biol. 2024 Oct 8:qiae219. doi: 10.1093/jleuko/qiae219. Online ahead of print. ABSTRACT Myeloid cell production of interleukin-1β (IL-1β) drives inflammaging in visceral adipose tissue (vWAT) and contributes to the expansion of interleukin-1 receptor 1 (Il1r1) positive aged adipose B-cells (AABs). AABs promote metabolic dysfunction and inflammation under inflammatory challenges. However, it is unclear whether … Read more

J Leukoc Biol. 2024 Oct 7:qiae216. doi: 10.1093/jleuko/qiae216. Online ahead of print. ABSTRACT Thymic stromal lymphopoietin (TSLP) is an established pleotropic alarmin cytokine that is generated at barrier tissues to induce type 2 immune responses, but its role in regulating the diversity of B cells is poorly understood. Here, we will highlight the key findings … Read more

J Leukoc Biol. 2024 Oct 4:qiae218. doi: 10.1093/jleuko/qiae218. Online ahead of print. ABSTRACT Extravasation of CCR2-positive monocytes into tissue and to the site of injury is a fundamental immunological response to infections. Nevertheless, exuberant recruitment and/or activity of these monocytes and monocyte-derived macrophages can propagate tissue damage, especially in chronic inflammatory disease conditions. We have … Read more

J Leukoc Biol. 2024 Oct 4:qiae214. doi: 10.1093/jleuko/qiae214. Online ahead of print. ABSTRACT Galectins constitute a family of soluble lectins with unique capacity to induce macroscale rearrangements upon interacting with cell membrane glycoconjugates. Galectin-8 (Gal-8) is acknowledged for its role in facilitating antigen uptake and processing upon engaging with cell surface glycoconjugates on antigen-presenting cells … Read more

J Leukoc Biol. 2024 Oct 3:qiae215. doi: 10.1093/jleuko/qiae215. Online ahead of print. ABSTRACT Approximately one million cases of sepsis in the U.S.A. occur annually. The early phase of sepsis features dramatic changes in host metabolism and inflammation. While examining the effects of metabolic pathways on inflammation, we discovered that the highly reactive glycolytic metabolite, methylglyoxal … Read more

J Leukoc Biol. 2024 Oct 1:qiae198. doi: 10.1093/jleuko/qiae198. Online ahead of print. ABSTRACT Treatment with the toll-like receptor (TLR) 4 agonist monophosphoryl lipid A (MPLA) conditions innate immunocytes to respond robustly to subsequent infection, a phenotype termed innate immune memory. Our published studies show that metabolic reprogramming of macrophages is a prominent feature of the … Read more