J Leukoc Biol. 2024 Dec 24:qiae258. doi: 10.1093/jleuko/qiae258. Online ahead of print. ABSTRACT INTRODUCTION: Granulocyte concentrates (GC) are leukocyte preparations enriched in neutrophils that can potentially save neutropenic patients from life-threatening, antimicrobial-resistant infections. The main challenge of GC transfusions is preserving the viability and antimicrobial activity of neutrophils beyond 24 h to reduce the logistical … Read more

J Leukoc Biol. 2024 Dec 19:qiae255. doi: 10.1093/jleuko/qiae255. Online ahead of print. ABSTRACT The neutrophil marker CD177 (NB1, HNA-2a) is expressed by 0-100% of circulating neutrophils in any given donor, dividing neutrophils into two distinct subpopulations (CD177pos and CD177neg). High proportions of CD177pos blood neutrophils have been linked to both systemic infections and a range … Read more

J Leukoc Biol. 2024 Dec 17:qiae254. doi: 10.1093/jleuko/qiae254. Online ahead of print. ABSTRACT Psoriasis is a chronic inflammatory skin disease characterized by periods of remission and relapse. In this pathology, keratinocytes, dendritic cells, and different subpopulations of T cells are critical to developing psoriatic lesions. Although current treatments can reduce symptoms, they reappear in previously … Read more

J Leukoc Biol. 2024 Dec 17:qiae253. doi: 10.1093/jleuko/qiae253. Online ahead of print. ABSTRACT While widely viewed as inhibitory receptors that drive efferocytosis and immune resolution on myeloid cells, TAM family members, particularly Mertk, have emerged as promising targets in immune-oncology to help stimulate host anti-tumor immunity. A recent study shows that Mertk expressed on human … Read more

J Leukoc Biol. 2024 Dec 4:qiae251. doi: 10.1093/jleuko/qiae251. Online ahead of print. ABSTRACT γδ T cells play diverse roles in immune responses, producing either IL-17A or IFN-γ. Here we investigated the impact of this functional dichotomy on cutaneous leishmaniasis. We demonstrate that in Sv129 mice susceptible to Leishmania amazonensis, Vγ4+ γδ T cells are the … Read more

J Leukoc Biol. 2024 Nov 28:qiae252. doi: 10.1093/jleuko/qiae252. Online ahead of print. ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of the coronavirus disease 2019 (COVID-19) pandemic, remains endemic worldwide. Circulating levels of the chemokine CXCL10 are strongly positively associated with poor outcome; however, its precise role in SARS-CoV-2 pathogenesis and its … Read more

J Leukoc Biol. 2024 Nov 22:qiae249. doi: 10.1093/jleuko/qiae249. Online ahead of print. ABSTRACT The pre-T cell receptor (TCR) and TCR complexes are frequently expressed in T-cell acute lymphoblastic leukemia (T-ALL), an aggressive T cell precursor malignancy. Although mutations in TCR components are infrequent in T-ALL, earlier research indicated that transgenic αβ TCR expression in mouse … Read more

J Leukoc Biol. 2024 Nov 20:qiae248. doi: 10.1093/jleuko/qiae248. Online ahead of print. ABSTRACT Brain metastases (BrM) originating from lung and breast cancer can recruit and activate neutrophils to acquire a tumor-promoting phenotype. It is currently unclear if this phenomenon also occurs in BrM arising from other primary sites. Here, we investigated the effect of tumor … Read more

J Leukoc Biol. 2024 Nov 14:qiae246. doi: 10.1093/jleuko/qiae246. Online ahead of print. ABSTRACT Tuberculosis (TB) is one of the leading causes of death worldwide and a major public health problem. Immune evasion mechanisms and antibiotic resistance highlight the need to better understand this disease and explore alternative treatment approaches. Mycobacterial infection modulates the macrophage response … Read more

J Leukoc Biol. 2024 Nov 12:qiae239. doi: 10.1093/jleuko/qiae239. Online ahead of print. ABSTRACT Oral mucosal colonization by C. albicans (Ca) is benign in healthy people but progresses to deeper infection known as oropharyngeal candidiasis (OPC) that may become disseminated when combined with immunosuppression. Cortisone use and neutropenia are risk factors for invasive mucosal fungal infections, … Read more