Journal of Leukocyte Biology

Reversible role of MIR654/3P and MIR9/3P in pathogenesis of Epstein-Barr Virus negative, but not positive, Burkitt’s lymphoma​Yu Gong on 24 de October de 2024 at 10:00

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J Leukoc Biol. 2024 Oct 24:qiae237. doi: 10.1093/jleuko/qiae237. Online ahead of print. ABSTRACT The role of MIR654 in Burkitt’s lymphoma (BL) and whether it impacts expression of MYC, and its downstream activated MIR9 is not known. Expression of MYC, MYCN, MYCL, MIR9/3P, MIR654/5P, and MIR654/3P were assessed by qRT-PCR in biopsy samples from Epstein-Barr virus … Read more

Characteristics of the IgM Repertoires in the Peripheral Blood of Early Rheumatoid Arthritis Patients​Binbin Hong on 24 de October de 2024 at 10:00

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J Leukoc Biol. 2024 Oct 24:qiae236. doi: 10.1093/jleuko/qiae236. Online ahead of print. ABSTRACT Rheumatoid arthritis is a common autoimmune disease, but little is known about the characteristics of the B cell repertoires in the peripheral blood. In this study, the peripheral IgM repertoires of early rheumatoid arthritis (ERA) patients were analyzed by high-throughput sequencing and … Read more

Distinct deregulation trends of transcriptional protein complexes in aging naive T cells​Emel Kökrek on 22 de October de 2024 at 10:00

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J Leukoc Biol. 2024 Oct 22:qiae231. doi: 10.1093/jleuko/qiae231. Online ahead of print. ABSTRACT The impact of aging on T cell subsets, specifically CD4+ and CD8+ T cells, leading to immune system dysfunction, has been the focus of scientific investigation due to its potential to reverse age-associated deterioration. Transcriptomic and epigenomic studies have identified the primary … Read more

Machine learning algorithm approach to complete blood count can be used as early predictor of COVID-19 outcome​Cecília Horta Ramalho-Pinto on 21 de October de 2024 at 10:00

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J Leukoc Biol. 2024 Oct 21:qiae223. doi: 10.1093/jleuko/qiae223. Online ahead of print. ABSTRACT Although the SARS-CoV-2 infection has established risk groups, identifying biomarkers for disease outcomes is still crucial to stratify patient risk and enhance clinical management. Optimal efficacy of COVID-19 antiviral medications relies on early administration within the initial five days of symptoms, assisting … Read more

Basophils Induce Pro-Tumorigenic Cytokines from A549 Lung Adenocarcinoma via Mechanisms Requiring IgE, Galectin-3, and IL-3 Priming​John T Schroeder on 21 de October de 2024 at 10:00

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J Leukoc Biol. 2024 Oct 21:qiae233. doi: 10.1093/jleuko/qiae233. Online ahead of print. ABSTRACT Galectin-3 (Gal-3) is implicated in innate immune cell activation in a host of diseases/conditions. We identified a unique response whereby human basophils secrete IL-4/IL-13 when co-cultured with A549 cells -a lung adenocarcinoma. While displaying parameters consistent with standard IgE-dependent activation, these Galectin-3-dependent … Read more

Single-cell transcriptome analysis reveals atypical monocytes circulating ahead of acute graft-versus-host disease clinical onset​Filipe Martins on 21 de October de 2024 at 10:00

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J Leukoc Biol. 2024 Oct 21:qiae229. doi: 10.1093/jleuko/qiae229. Online ahead of print. ABSTRACT Acute graft-versus-host disease (aGVHD) represents the rejection of the recipient’s skin, gut, and liver tissues of an allogeneic hematopoietic stem cell transplantation (HSCT) by the donor T-cells. The onset of aGVHD is often rapid and its evolution is unpredictable. We undertook the … Read more

MerTK Signaling in Human Primary T cells Modulates Memory Potential and Improves Recall response​Anne Rahbech on 18 de October de 2024 at 10:00

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J Leukoc Biol. 2024 Oct 18:qiae226. doi: 10.1093/jleuko/qiae226. Online ahead of print. ABSTRACT Immune therapy using checkpoint inhibitors or adoptive cell transfer has revolutionized the treatment of several types of cancers. However, response to treatment is currently limited to a fraction of patients. Elucidation of immune modulatory mechanisms might optimize patient selection and present ways … Read more

The Peripheral Neuroimmune System​Keaton Song on 18 de October de 2024 at 10:00

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J Leukoc Biol. 2024 Oct 18:qiae230. doi: 10.1093/jleuko/qiae230. Online ahead of print. ABSTRACT Historically, the nervous and immune systems were studied as separate entities. The nervous system relays signals between the body and the brain by processing sensory inputs and executing motor outputs, whereas the immune system provides protection against injury and infection through inflammation. … Read more

A new model measuring bacterial phagocytosis and phagolysosomal oxidisation in humans using the intradermal injection of methylene blue-labelled Escherichia coli​George B Collins on 16 de October de 2024 at 10:00

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J Leukoc Biol. 2024 Oct 16:qiae217. doi: 10.1093/jleuko/qiae217. Online ahead of print. ABSTRACT Phagocytosis is an important leucocyte function, however using existing models it cannot be measured in human tissues in vivo. To address this, we characterized a new phagocytosis model using intradermal methylene blue-labelled Escherichia coli injection (MBEC). Methylene blue (MB) is a licensed … Read more

Polarization of the memory B cell response​Lizzette Pérez-Pérez on 14 de October de 2024 at 10:00

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J Leukoc Biol. 2024 Oct 14:qiae228. doi: 10.1093/jleuko/qiae228. Online ahead of print. ABSTRACT Memory B cells are long-lived cells that are induced following infection or vaccination. Upon antigen re-encounter, memory B cells rapidly differentiate into antibody-secreting or germinal center B cells. While memory B cells are an important component of long-term protective immunity following vaccination, … Read more

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