Journal of Leukocyte Biology

J Leukoc Biol. 2025 Jun 23:qiaf095. doi: 10.1093/jleuko/qiaf095. Online ahead of print. ABSTRACT Human immunodeficiency virus type 1 (HIV-1) and Mycobacterium tuberculosis (Mtb) co-infection poses a significant public health threat, characterized by a high mortality rate due to impaired host immune responses. In this study, we investigated the role of autophagy, primarily using macrophage cell … Read more

J Leukoc Biol. 2025 Jun 20:qiaf085. doi: 10.1093/jleuko/qiaf085. Online ahead of print. ABSTRACT Despite recent advances, the regulation of anticancer and antimicrobial bioactive compound (AABC) production by leukocytes remains poorly understood. Here, we demonstrate that inactivation of the DNA- and RNA-based Teazeled receptors of the Universal Receptive System in human leukocytes generated so called “Leukocyte-Tells,” … Read more

J Leukoc Biol. 2025 Jun 18:qiaf090. doi: 10.1093/jleuko/qiaf090. Online ahead of print. ABSTRACT Neutrophils are innate immune cells that drive the progression of rheumatoid arthritis (RA) through the release of reactive oxygen species (ROS), neutrophil extracellular traps (NETs) and proteases that damage host tissues. Neutrophil activation is regulated, in part, by dynamic changes in gene … Read more

J Leukoc Biol. 2025 Jun 19:qiaf092. doi: 10.1093/jleuko/qiaf092. Online ahead of print. ABSTRACT Diffuse large B-cell lymphoma (DLBCL) is highly heterogeneous and prone to epigenetic mutations. Non-apoptotic cell death pathways, especially ferroptosis, have become an emerging direction for cancer treatment. This project was designed to probe into the potential of histone-lysine N-methyltransferase 2D (KMT2D) in … Read more

J Leukoc Biol. 2025 Jun 18:qiaf083. doi: 10.1093/jleuko/qiaf083. Online ahead of print. ABSTRACT MicroRNA-93 (miR-93) has been implicated in the pathogenesis of myelodysplastic syndrome (MDS), though its precise role in the regulation of hematopoiesis and cell fate in MDS remains poorly understood. This study aimed to investigate the impact of miR-93 on cell proliferation, apoptosis, … Read more

J Leukoc Biol. 2025 Jun 18:qiaf087. doi: 10.1093/jleuko/qiaf087. Online ahead of print. ABSTRACT There is compelling evidence that tumor necrosis factor (TNF) receptor type II (TNFR2) mediates the stimulatory effect of TNF on the activation of CD4+Foxp3+ regulatory T cells (Tregs). Tregs with high TNFR2 expression are critical components of tumor microenvironment (TME), where they … Read more

J Leukoc Biol. 2025 Jun 27:qiaf096. doi: 10.1093/jleuko/qiaf096. Online ahead of print. ABSTRACT Toll-like receptor (TLR)2 activation induces aldehyde dehydrogenase enzymes in non-mucosal dendritic cells (DCs) enabling them to metabolize vitamin A into all-trans retinoic acid, which induces the expression of mucosal-homing molecules (α4β7 and CCR9) in the activated T cells. Recently, we have shown … Read more

J Leukoc Biol. 2025 Jun 27:qiaf097. doi: 10.1093/jleuko/qiaf097. Online ahead of print. ABSTRACT Food allergies, particularly peanut allergies, are on the rise, affecting ∼10% of the U.S. population and 17% of adults. We explored sex-based differences in inflammatory responses to peanut allergens using a mouse model. Female mice exhibited severe allergic symptoms and a greater … Read more

J Leukoc Biol. 2025 Jun 25:qiaf093. doi: 10.1093/jleuko/qiaf093. Online ahead of print. ABSTRACT Megakaryocyte emperipolesis is a biological process in which a cell penetrates and exists as a viable intact cell within another. It is a recognized morphological feature of myeloproliferative neoplasms (MPN), where neutrophils can be seen within megakaryocytes in bone marrow smears and … Read more

J Leukoc Biol. 2025 Jun 25:qiaf088. doi: 10.1093/jleuko/qiaf088. Online ahead of print. ABSTRACT Liver macrophages play important roles in the pathophysiology of liver fibrosis and hepatocellular carcinoma (HCC). However, liver macrophages are a heterogenous population and have differing roles in maintenance of liver function and response in disease. In a healthy liver, macrophages play a … Read more