Mucosal Immunology

Mucosal Immunol. 2024 Dec 13:S1933-0219(24)00130-2. doi: 10.1016/j.mucimm.2024.12.007. Online ahead of print. ABSTRACT Decidual CD8+T (dCD8+T) cells are pivotal in the maintenance of the delicate balance between immune tolerance towards the fetus and immune resistance against pathogens. The endometrium and decidua represent uterine environments before and during pregnancy, respectively, and the composition and phenotypic alterations of … Read more

Mucosal Immunol. 2024 Dec 13:S1933-0219(24)00129-6. doi: 10.1016/j.mucimm.2024.12.006. Online ahead of print. ABSTRACT We aimed to elucidate the dynamic changes in short-chain fatty acids (SCFA) produced by the gut microbiota following smoking exposure and their role in chronic obstructive pulmonary disease (COPD) pathogenesis. SCFA concentrations were measured in human plasma, comparing non-smokers (n = 6) and … Read more

Mucosal Immunol. 2024 Dec 13:S1933-0219(24)00131-4. doi: 10.1016/j.mucimm.2024.12.008. Online ahead of print. ABSTRACT Despite the central role of cytokines in mediating inflammation that underlies a range of childhood diseases, cytokine testing remains primarily limited to research settings and surrogate markers of inflammation are often used to inform clinical diagnostic and treatment decisions. There are currently no … Read more

Mucosal Immunol. 2024 Dec 13:S1933-0219(24)00128-4. doi: 10.1016/j.mucimm.2024.12.005. Online ahead of print. ABSTRACT Despite advances in our understanding of their diagnosis and treatment, pediatric allergies impose substantial burdens on affected children, families, and healthcare systems. Further, the prevalence of allergic diseases has dramatically increased over the past half-century, leading to additional concerns and concerted efforts to … Read more

Mucosal Immunol. 2024 Dec 11:S1933-0219(24)00126-0. doi: 10.1016/j.mucimm.2024.12.003. Online ahead of print. ABSTRACT In complex organisms, functional units must interact cohesively to maintain homeostasis, especially within mucosal barriers that house diverse, specialized cell exposed to constant environmental challenges. Understanding how homeostasis at mucosal barriers is maintained and how its disruption can lead to autoimmune diseases or … Read more

Mucosal Immunol. 2024 Dec 9:S1933-0219(24)00127-2. doi: 10.1016/j.mucimm.2024.12.004. Online ahead of print. ABSTRACT The role of innate receptors in initiating the early inflammatory response to helminth larval stages in affected tissues during their life cycle within the host remains poorly understood. Given its pivotal role in detecting microbial elements and eliciting immune responses, exploring the NOD1 … Read more

Mucosal Immunol. 2024 Dec 9:S1933-0219(24)00124-7. doi: 10.1016/j.mucimm.2024.12.001. Online ahead of print. ABSTRACT Interleukin (IL)-33 is released following tissue damage, causing airway inflammation and remodelling via reduced IL-33 (IL-33red)/serum stimulation-2 (ST2) and oxidised IL-33 (IL-33ox)/receptor for advanced glycation end products (RAGE)/epidermal growth factor receptor (EGFR) pathways. This study aimed to identify associations of IL-33 with clinical … Read more

Mucosal Immunol. 2024 Dec 9:S1933-0219(24)00125-9. doi: 10.1016/j.mucimm.2024.12.002. Online ahead of print. ABSTRACT Recent evidence suggests that the gut microbiota can influence pain sensitivity, highlighting the potential for microbiota-targeted pain interventions. During early life, both the microbiota and nociceptors are fine-tuned and respond to environmental factors, however, little is known about how they interact with each … Read more

Mucosal Immunol. 2024 Nov 24:S1933-0219(24)00115-6. doi: 10.1016/j.mucimm.2024.11.007. Online ahead of print. ABSTRACT Interleukin (IL)-33 is a key responder to intestinal injury and inflammation. In the colon, it is expressed by several cell populations, with the specific cellular source likely determining its role. The colonic epithelium expresses IL-33; however, the factors controlling its production and the … Read more

Mucosal Immunol. 2024 Nov 24:S1933-0219(24)00117-X. doi: 10.1016/j.mucimm.2024.11.009. Online ahead of print. ABSTRACT Host-directed therapy, using nasal administration of the Toll-like receptor 5 agonist flagellin in combination with antibiotics, has proven effective against pneumococcal pneumonia. In this study, we investigated the immune mechanisms underlying the therapy-induced protective effects. Transcriptomic analysis of lung tissue during infection revealed … Read more