Mucosal Immunology

Mucosal Immunol. 2026 Jan 7:S1933-0219(26)00002-4. doi: 10.1016/j.mucimm.2026.01.002. Online ahead of print. ABSTRACT Type 2 cytokinerelease promotes wound healing and helminth clearance, but it remains unclearwhethergroup 2 innate lymphocytes (ILC2s) and T-helper2 cells (TH2) cells have functionally distinctroles during anamnestic immunity. This study demonstrates that ILC2 can prevent re-infection andlimit tissue injury caused by the helminthNippostrongylus … Read more

Mucosal Immunol. 2025 Dec 30:S1933-0219(25)00141-2. doi: 10.1016/j.mucimm.2025.12.005. Online ahead of print. ABSTRACT The intestinal epithelium undergoes robust maturation postnatally, yet its early-life characteristics remain poorly understood. Using single-cell RNA sequencing, we analyzed intestinal epithelial cells from neonatal (10-day-old) and juvenile (21-day-old) mice reared under both specific pathogen-free and germ-free conditions. Among the various cell types … Read more

Mucosal Immunol. 2025 Dec 30:S1933-0219(25)00142-4. doi: 10.1016/j.mucimm.2025.12.006. Online ahead of print. NO ABSTRACT PMID:41478462 | DOI:10.1016/j.mucimm.2025.12.006

Mucosal Immunol. 2025 Dec 27:S1933-0219(25)00140-0. doi: 10.1016/j.mucimm.2025.12.004. Online ahead of print. ABSTRACT Regulatory T (Treg) cells are well recognized for their role in immune regulation; however, their role in tissue regeneration is not fully understood. This study demonstrates such a role of Tregs in a published preclinical murine model of spontaneous pulmonary fibrosis (PF) expressing … Read more

Mucosal Immunol. 2025 Dec 22:S1933-0219(25)00139-4. doi: 10.1016/j.mucimm.2025.12.003. Online ahead of print. ABSTRACT Reduced dietary fiber intake is associated with, and may have contributed to, the post-mid-20th century increase in immune-mediated chronic inflammatory diseases, including inflammatory bowel disease (IBD). Reduced fiber intake has resulted, in part, from increased consumption of highly refined foods including those made … Read more

Mucosal Immunol. 2025 Dec 21:S1933-0219(25)00137-0. doi: 10.1016/j.mucimm.2025.12.001. Online ahead of print. ABSTRACT The intestine and liver are physically interconnected through the biliary system, portal circulation, lymphatic network, and neural pathways, collectively forming the gut-liver axis. The gut-liver axis and the immune system are engaged in a complex regulatory relationship. Over the past few decades, significant … Read more

Mucosal Immunol. 2025 Dec 21:S1933-0219(25)00138-2. doi: 10.1016/j.mucimm.2025.12.002. Online ahead of print. ABSTRACT Human astroviruses (HAstVs) are a global cause of pediatric gastroenteritis and can cause disseminated infection in immunocompromised hosts. Murine astrovirus (muAstV) causes acute asymptomatic infections in immunocompetent mice and chronic infection in immunodeficient models and has provided important insights into AstV pathogenesis in … Read more

Mucosal Immunol. 2025 Dec 11:S1933-0219(25)00131-X. doi: 10.1016/j.mucimm.2025.11.014. Online ahead of print. NO ABSTRACT PMID:41381285 | DOI:10.1016/j.mucimm.2025.11.014

Mucosal Immunol. 2025 Nov 28:S1933-0219(25)00129-1. doi: 10.1016/j.mucimm.2025.11.012. Online ahead of print. ABSTRACT Natural Killer (NK) cells are cytotoxic lymphocytes and key mediators of innate immunity, essential for combating viral infections and cancer. Notably, they exhibit immunological memory, generating a stronger response upon re-exposure to the same stimulus. While NK cell memory holds promise for infection … Read more

Mucosal Immunol. 2025 Nov 27:S1933-0219(25)00130-8. doi: 10.1016/j.mucimm.2025.11.013. Online ahead of print. ABSTRACT Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition affecting the gastrointestinal tract. It is characterised by epithelial and immunological dysfunctions, including alterations in populations of Innate Lymphoid Cells (ILCs), including tissue-resident RORγt-expressing Group 3 ILCs (ILC3s). ILC3s contribute to the maintenance of … Read more