Mucosal Immunol. 2025 Jun 27:S1933-0219(25)00068-6. doi: 10.1016/j.mucimm.2025.06.008. Online ahead of print. ABSTRACT Poorly controlled diabetes significantly transforms periodontal disease from manageable to advanced, affecting millions worldwide, yet the mechanisms driving this destructive synergy remain unclear. To investigate these pathological interactions, we generated single-cell RNA sequencing profiles of diabetic periodontal tissue, revealing γδ T-cells as previously … Read more

Mucosal Immunol. 2025 Jun 27:S1933-0219(25)00069-8. doi: 10.1016/j.mucimm.2025.06.009. Online ahead of print. NO ABSTRACT PMID:40582571 | DOI:10.1016/j.mucimm.2025.06.009

Mucosal Immunol. 2025 Jun 24:S1933-0219(25)00067-4. doi: 10.1016/j.mucimm.2025.06.007. Online ahead of print. ABSTRACT Desmosomes are junctional complexes that confer mechanical strength and enhance barrier protection at mucosal epithelial surfaces by anchoring intermediate filaments to plasma membrane. These roles are best defined in cutaneous epithelium, but we previously identified lower levels of the desmosomal cadherins desmoglein-1 (DSG1) … Read more

Mucosal Immunol. 2025 Jun 13:S1933-0219(25)00066-2. doi: 10.1016/j.mucimm.2025.06.006. Online ahead of print. ABSTRACT Maternal exposure to environmental change during pregnancy is a critical determinant of offspring health and disease. Previous epidemiological studies have reported that maternal inflammation is linked to an increased incidence of postnatal allergy in offspring, although the underlying mechanisms remain largely unexplored. In … Read more

Mucosal Immunol. 2025 Jun 12:S1933-0219(25)00065-0. doi: 10.1016/j.mucimm.2025.06.005. Online ahead of print. ABSTRACT Numerous studies have shown that tissue-resident memory T (TRM) cells form in the intestine following pathogen clearance. However, most knowledge of intestinal TRM cells has derived from analyses restricted to the small intestine (SI). In contrast, less is known about TRM cell formation … Read more

Mucosal Immunol. 2025 Jun 10:S1933-0219(25)00064-9. doi: 10.1016/j.mucimm.2025.06.004. Online ahead of print. ABSTRACT Intestinal epithelial cells need to be able to launch a quick and adequate immune response against pathogens, while tolerating commensals. This delicate balance requires a tight control over the activation of the NFκB and Interferon pathways to prevent chronic inflammation. Simultaneously, intestinal stem … Read more

Mucosal Immunol. 2025 Jun 9:S1933-0219(25)00055-8. doi: 10.1016/j.mucimm.2025.05.009. Online ahead of print. ABSTRACT Oral lichen planus (OLP) is a chronic inflammatory disorder with autoimmune features and malignant transformation risk, lacking a definitive treatment, with CD4+ T cells being pivotal in its pathogenesis. Dysbiosis, an imbalance in the microbiome, is linked to various autoimmune and inflammatory diseases, … Read more

Mucosal Immunol. 2025 Jun 7:S1933-0219(25)00058-3. doi: 10.1016/j.mucimm.2025.06.002. Online ahead of print. ABSTRACT Chronic gastrointestinal diseases are a significant global health burden that can require the use of gastrointestinal-cleansing regimens for diagnostics or therapeutic treatment. These regimens are beneficial for facilitating surgical preparation, drug delivery, colorectal cancer screenings, and personal use is common among proponents of … Read more

Mucosal Immunol. 2025 Jun 5:S1933-0219(25)00057-1. doi: 10.1016/j.mucimm.2025.06.001. Online ahead of print. ABSTRACT As professional and long-lived immunoglobulin (Ig) producers, B cells represent attractive candidates for adoptive immunotherapy and their highly expressed Ig heavy (IgH) chain locus is ideal for editing. Each of its constant genes, expressed after class switch recombination (CSR), affords an attractive platform … Read more

Mucosal Immunol. 2025 Jun 4:S1933-0219(25)00056-X. doi: 10.1016/j.mucimm.2025.05.008. Online ahead of print. ABSTRACT Intestinal fibrosis is one of the most threatening complications of Crohn’s disease (CD). Although our previous study identified the profibrotic role of amphiregulin (AREG) in intestinal fibrosis, the underlying molecular mechanisms remain poorly understood. This study aimed to elucidate the mechanisms by which … Read more