Mucosal Immunology

Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus. Stephanie N Langel

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Mucosal Immunol. 2025 Jan 20:S1933-0219(25)00002-9. doi: 10.1016/j.mucimm.2025.01.002. Online ahead of print. ABSTRACT Dimeric IgA (dIgA) is the dominant antibody in many mucosal tissues. It is actively transported onto mucosal surfaces as secretory IgA (sIgA) which plays an integral role in protection against enteric pathogens, particularly in young children. Therapeutic strategies that deliver engineered, potently neutralizing … Read more

Sialidase fusion protein protects against influenza infection in a cigarette smoke-induced model of COPD. Cheng-Yen Chang

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Mucosal Immunol. 2025 Jan 19:S1933-0219(25)00004-2. doi: 10.1016/j.mucimm.2025.01.004. Online ahead of print. ABSTRACT First- and secondhand smokers are at an increased risk for influenza virus (IFV)-related respiratory failure and death. Despite approved influenza antiviral treatments, there is an unmet need for treatments that can improve outcomes in populations at risk for respiratory failure, including tobacco users … Read more

T follicular helper cell expansion and hyperimmunoglobulinemia with spontaneous IgE production to dietary antigens in IgA-deficient mice. Yasmeen S El Ansari

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Mucosal Immunol. 2025 Jan 15:S1933-0219(25)00005-4. doi: 10.1016/j.mucimm.2025.01.005. Online ahead of print. ABSTRACT Immunoglobulin A (IgA), the most abundantly produced antibody at mucosal surfaces, is thought to play key roles in immune responses to respiratory and enteric pathogens and in the regulation of commensal colonization. Low IgA levels have been associated with recurrent infections and immune … Read more

Immune crosstalk between respiratory and intestinal mucosal tissues in respiratory infections. Min Zhao

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Mucosal Immunol. 2025 Jan 2:S1933-0219(24)00136-3. doi: 10.1016/j.mucimm.2024.12.013. Online ahead of print. ABSTRACT Mucosal tissues, including those in the respiratory and gastrointestinal tracts, are critical barrier surfaces for pathogen invasion. Infections at these sites not only trigger local immune response, but also recruit immune cells from other tissues. Emerging evidence in mouse models and human samples … Read more

Targeting the EP2 receptor ameliorates inflammatory bowel disease in mice by enhancing the immunosuppressive activity of Treg cells. Chenchen Wang

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Mucosal Immunol. 2024 Dec 31:S1933-0219(24)00137-5. doi: 10.1016/j.mucimm.2024.12.014. Online ahead of print. ABSTRACT Inflammatory bowel diseases (IBDs) are characterized by unrestrained innate and adaptive immune responses and compromised intestinal epithelial barrier integrity. Regulatory T (Treg) cells are crucial for maintaining self-tolerance and immune homeostasis in intestinal tissues. Prostaglandin E2 (PGE2), a bioactive lipid compound derived from … Read more

Diabetes impairs IFNγ-dependent antibacterial defense in the lungs. Facundo Fiocca Vernengo

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Mucosal Immunol. 2024 Dec 31:S1933-0219(24)00138-7. doi: 10.1016/j.mucimm.2024.12.015. Online ahead of print. ABSTRACT Diabetes mellitus is associated with an increased risk of pneumonia, often caused by so-called typical and atypical pathogens including Streptoccocus pneumoniae and Legionella pneumophila, respectively. Here, we employed a variety of mouse models to investigate how diabetes influences pulmonary antibacterial immunity. Following intranasal … Read more

Glial-immune interactions in barrier organs. Julia Karjalainen

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Mucosal Immunol. 2024 Dec 21:S1933-0219(24)00135-1. doi: 10.1016/j.mucimm.2024.12.012. Online ahead of print. ABSTRACT Neuro-immune interactions within barrier organs, such as lung, gut, and skin, are crucial in regulating tissue homeostasis, inflammatory responses, and host defence. Our rapidly advancing understanding of peripheral neuroimmunology is transforming the field of barrier tissue immunology, offering a fresh perspective for developing … Read more

Neutrophil NADPH oxidase promotes bacterial eradication and regulates NF-κB-Mediated inflammation via NRF2 signaling during urinary tract infections. Israel Cotzomi-Ortega

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Mucosal Immunol. 2024 Dec 20:S1933-0219(24)00133-8. doi: 10.1016/j.mucimm.2024.12.010. Online ahead of print. ABSTRACT The precise role of neutrophil-derived reactive oxygen species (ROS) in combating bacterial uropathogens during urinary tract infections (UTI) remains largely unexplored. In this study, we elucidate the antimicrobial significance of NADPH oxidase 2 (NOX2)-derived ROS, as opposed to mitochondrial ROS, in facilitating neutrophil-mediated … Read more

Tissue-resident natural killer cells derived from conventional natural killer cells are regulated by progesterone in the uterus. Bruna K Tatematsu

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Mucosal Immunol. 2024 Dec 19:S1933-0219(24)00132-6. doi: 10.1016/j.mucimm.2024.12.009. Online ahead of print. ABSTRACT The murine uterus contains three subsets of innate lymphoid cells (ILCs). Innate lymphoid cell type 1 (ILC1) and conventional natural killer (cNK) cells seed the uterus before puberty. Tissue-resident NK (trNK) cells emerge at puberty and vary in number during the estrous cycle. … Read more

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