Nature Reviews Immunology, Published online: 16 October 2025; doi:10.1038/s41577-025-01226-6As more spaceflight missions plan to take humans back to the moon — and beyond — a key goal is to understand how spaceflight affects the immune…
Nature Reviews Immunology, Published online: 14 October 2025; doi:10.1038/s41577-025-01229-3The tumour microenvironment (TME) poses a significant obstacle to the success of chimeric antigen receptor (CAR) T cell immunotherapy in solid …
Nature Reviews Immunology, Published online: 09 October 2025; doi:10.1038/s41577-025-01223-9In this Review, the authors discuss the latest advances in our understanding of organelle biology in T cell-mediated antitumour immunity and ho…
Nature Reviews Immunology, Published online: 08 October 2025; doi:10.1038/s41577-025-01233-7Amyotrophic lateral sclerosis is associated with CD4+ T cells that are specific for the C9orf72 autoantigen and preferentially produce IL-4, IL…
Nature Reviews Immunology, Published online: 07 October 2025; doi:10.1038/s41577-025-01234-6Depending on context and concentration, the polyamine cadaverine can promote pro- or anti-inflammatory macrophage polarizations.
Nature Reviews Immunology, Published online: 07 October 2025; doi:10.1038/s41577-025-01236-4A proteotoxic stress response specific to exhausted T cells represents a target for cancer immunotherapy.
Nature Reviews Immunology, Published online: 07 October 2025; doi:10.1038/s41577-025-01235-5Group 2 innate lymphoid cells are crucial for maintaining nerve structure and pain thresholds.
Nature Reviews Immunology, Published online: 06 October 2025; doi:10.1038/s41577-025-01227-5This Review explains how an improved understanding of immune and nervous system interactions in the central nervous system (CNS) has guided the…
Nature Reviews Immunology, Published online: 03 October 2025; doi:10.1038/s41577-025-01232-8A study in Science Immunology reports that regulatory T cells in the skin modulate neuronal tone directly through their production of the opioi…
Nature Reviews Immunology, Published online: 01 October 2025; doi:10.1038/s41577-025-01221-xHere, Sun and Dong describe the many signals from stimulatory and inhibitory molecules as well as by microenvironmental factors, such as cytoki…
