ILC2–neuron cross-talk regulates pain sensitivity and gait
Nature Reviews Immunology, Published online: 07 October 2025; doi:10.1038/s41577-025-01235-5Group 2 innate lymphoid cells are crucial for maintaining nerve structure and pain thresholds.
Nature Reviews Immunology
The promise of immunotherapy for central nervous system tumours
Nature Reviews Immunology, Published online: 06 October 2025; doi:10.1038/s41577-025-01227-5This Review explains how an improved understanding of immune and nervous system interactions in the central nervous system (CNS) has guided the…
Skin T<sub>reg</sub> cells set the tone for neuronal activation
Nature Reviews Immunology, Published online: 03 October 2025; doi:10.1038/s41577-025-01232-8A study in Science Immunology reports that regulatory T cells in the skin modulate neuronal tone directly through their production of the opioi…
Regulators of CD8<sup>+</sup> T cell exhaustion
Nature Reviews Immunology, Published online: 01 October 2025; doi:10.1038/s41577-025-01221-xHere, Sun and Dong describe the many signals from stimulatory and inhibitory molecules as well as by microenvironmental factors, such as cytoki…
Clearing the hurdles for CAR-T cell treatment
Nature Reviews Immunology, Published online: 22 September 2025; doi:10.1038/s41577-025-01228-4Many patients with cancer who could potentially benefit from treatment with chimeric antigen receptor (CAR)-T cells do not have access to thi…
Lessons from neoadjuvant immunotherapy in melanoma: understanding antitumour immunity and tumour escape
Nature Reviews Immunology, Published online: 22 September 2025; doi:10.1038/s41577-025-01222-wNeoadjuvant (chemo)immunotherapy has become a new standard-of-care option for patients with cancer. This Perspective discusses the lessons le…
Targets of protective immunity and opportunities in hepatitis C virus vaccine development
Nature Reviews Immunology, Published online: 12 September 2025; doi:10.1038/s41577-025-01215-9Despite the advances in hepatitis C treatment, a prophylactic vaccine is still not available and will be needed to control and eliminate hepa…
Immune-related actinopathies at the cross-road of immunodeficiency, autoimmunity and autoinflammation
Nature Reviews Immunology, Published online: 10 September 2025; doi:10.1038/s41577-025-01214-wThe actin cytoskeleton is essential for immune cell shape, signalling and function. In this Review, the authors examine how germ-line mutatio…
Metabolic control of innate-like T cells
Nature Reviews Immunology, Published online: 08 September 2025; doi:10.1038/s41577-025-01219-5Functional and metabolic properties of innate-like T cells — namely, iNKT cells, MAIT cells and some γδ T cells — differ from those of conven…
Targeting MHC-E as a new strategy for vaccines and immunotherapeutics
Nature Reviews Immunology, Published online: 03 September 2025; doi:10.1038/s41577-025-01218-6The dual nature of non-polymorphic MHC-E as a ligand for innate receptors and as an antigen-presenting protein raises the possibility of new,…