Publicaciones
Linear epitopes of bony fish β-parvalbumins
IntroductionFish β-parvalbumins are common targets of allergy-causing immunity. The nature of antibody responses to such allergens determines the biological outcome following exposure to fish. Specific epitopes on these allergens recognised by antibodi…
Immune-mediated diseases are associated with a higher risk of ALS incidence: a prospective cohort study from the UK Biobank
ObjectiveThe occurrence of immune-mediated diseases (IMDs) in amyotrophic lateral sclerosis (ALS) patients is widely reported. However, whether IMDs and ALS is a simple coexistence or if there exists causal relationships between the two has been a subj…
Human tissue-resident peritoneal macrophages reveal resistance towards oxidative cell stress induced by non-invasive physical plasma
In the context of multimodal treatments for abdominal cancer, including procedures such as cytoreductive surgery and intraperitoneal chemotherapy, recurrence rates remain high, and long-term survival benefits are uncertain due to post-operative complic…
The endogenous Mtv8 locus and the immunoglobulin repertoire
The vast diversity of mammalian adaptive antigen receptors allows for robust and efficient immune responses against a wide number of pathogens. The antigen receptor repertoire is built during the recombination of B and T cell receptor (BCR, TCR) loci a…
Tyrosine phosphatase PTPN11/SHP2 in solid tumors – bull’s eye for targeted therapy?
Encoded by PTPN11, the Src-homology 2 domain-containing phosphatase 2 (SHP2) integrates signals from various membrane-bound receptors such as receptor tyrosine kinases (RTKs), cytokine and integrin receptors and thereby promotes cell survival and proli…
T-cell immunity against senescence: potential role and perspectives
The development of age-associated diseases is related to the accumulation of senescent cells in the body. These are old non-functional cells with impaired metabolism, which are unable to divide. Such cells are also resistant to programmed cell death an…
CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy
Franken et al. examine the mechanisms that differentiate combined therapy with anti-CTLA4 and anti-PD-L1 from anti-PD-L1 monotherapy in head and neck squamous cell carcinoma (HNSCC). Single-cell analyses of the tumor microenvironment, tumor-draining ly…
Calebin A modulates inflammatory and autophagy signals for the prevention and treatment of osteoarthritis
IntroductionOsteoarthritis (OA) is associated with excessive cartilage degradation, inflammation, and decreased autophagy. Insufficient efficacy of conventional monotherapies and poor tissue regeneration due to side effects are just some of the unresol…