Breast cancer stands as the most prevalent form of cancer among women globally, influenced by a combination of genetic and environmental factors. Recent studies have investigated changes in microRNAs (miRNAs) during breast cancer progression and the po…
IntroductionCOVID-19 vaccines are highly effective in inducing protective immunity. While the serum antibody response to COVID-19 vaccination has been studied in depth, our knowledge of the underlying plasmablast and memory B cell (Bmem) responses is s…
IntroductionThe pulmonary endothelium is the primary target of lung ischemia-reperfusion injury leading to primary graft dysfunction after lung transplantation. We hypothesized that treating damaged rat lungs by a transient heat stress during ex-vivo l…
Epithelial tuft cells serve as intestinal immune sentinels, but why they secrete acetylcholine remains unknown. Billipp et al. show that tuft cell chemosensing leads to acetylcholine release, which induces secretion of chloride and subsequently water f…
Intestinal tuft cells are known as sentinels capable of initiating type 2 immune responses upon parasite infections. Ndjim et al. now report a direct effector function for intestinal tuft cells during such immune responses by increasing their acetylcho…
RIPK1 regulates cell death via kinase-dependent and kinase-independent mechanisms. Utilizing mice expressing RIPK1 with a point mutation disrupting its death domain, Imai et al. show that RIPK1 death domain interactions are critical to suppress ZBP1- a…
Cellular & Molecular Immunology, Published online: 13 May 2024; doi:10.1038/s41423-024-01164-8Eomesodermin spatiotemporally orchestrates the early and late stages of NK cell development by targeting KLF2 and T-bet, respectively
Cellular & Molecular Immunology, Published online: 13 May 2024; doi:10.1038/s41423-024-01170-wGITR exacerbates lysophosphatidylcholine-induced macrophage pyroptosis in sepsis via posttranslational regulation of NLRP3
Cellular & Molecular Immunology, Published online: 13 May 2024; doi:10.1038/s41423-024-01171-9A novel target to turn cold tumors into hot tumors: lysosomal 25-hydroxycholesterol activates AMPKα and immunosuppressive tumor-associate…
