ObjectiveTo explore the real-world efficacy and safety of telitacicept in patients with systemic lupus erythematosus (SLE).MethodsThis retrospective study included SLE patients treated with telitacicept for at least 3 months at Mianyang Central Hospita…
IntroductionStem cell-derived organoids are promising platforms for therapeutic screening in inflammatory bowel disease (IBD), but identifying functional organoid readouts with translational utility is challenging. Colon epithelial organoids from patie…
IntroductionAdvances in single-cell and spatial profiling have enabled detailed characterization of heterogeneous samples, but analyzing this data remains challenging in settings involving multiple comparisons. While tools like UMAP and t-SNE are valua…
The aryl hydrocarbon receptor (AHR), which is a ligand-activated transcription factor, controls complex transcription programs in a ligand-specific, cell type-specific, and context-specific manner by integrating signals from the environment, diet, micr…
Epilepsy affects around 70 million people worldwide, and roughly one-third of them respond poorly to standard antiepileptic drugs. Current treatments are directed almost entirely at neurons, leaving the contribution of non-neuronal cells largely unaddr…
Idiosyncratic drug-induced liver injury (iDILI) is not a uniform disease but rather includes a variety of types based on immune, autoimmune, and clinical considerations. This review attempts to close information gaps regarding the role of immunity and …
Epitope spreading has long been proposed as a mechanism contributing to the progression of multiple sclerosis (MS), yet its role in human disease remains incompletely defined. Traditionally viewed as a consequence of antigen release during tissue damag…
BackgroundElectroacupuncture (EA) demonstrates efficacy in alleviating diarrhea-predominant irritable bowel syndrome (IBS-D), yet its mechanisms concerning low-grade intestinal inflammation remain insufficiently elucidated. This study investigated whet…
Background and objectivePolymorphisms of the vitamin D receptor (VDR) gene have been studied in relation to various diseases, including infections. This narrative review aims to summarize the role of VDR polymorphisms in the susceptibility towards pedi…
