Background and objectivePolymorphisms of the vitamin D receptor (VDR) gene have been studied in relation to various diseases, including infections. This narrative review aims to summarize the role of VDR polymorphisms in the susceptibility towards pedi…
J Immunol. 2026 Jul 10;215(7):vkag211. doi: 10.1093/jimmun/vkag211. ABSTRACT Obesity increases cancer incidence and aggressiveness but is paradoxically associated with improved response to immunotherapy. Here, we show that intratumoral levels of leptin (LEP), a factor contributing to the development of obesity, predict improved outcomes of breast and liver cancers. In contrast, these levels of LEP are … Read more
J Immunol. 2026 Jul 10;215(7):vkag203. doi: 10.1093/jimmun/vkag203. ABSTRACT The innate immune system can detect infection, tissue damage, and other homeostatic disruptions to initiate an immune response, drive inflammation, and promote programmed cell death. While these responses can be beneficial in host defense, aberrant activation of inflammatory, lytic cell death pathways can be pathogenic. Emerging evidence … Read more
Background
Mitophagy is a mitochondrial quality control process that maintains cellular homeostasis in cancer, yet whether its dysregulation can be exploited to induce tumor immunogenicity remains unclear.
Methods
We integrated pancancer single-cell …
Background
Natural killer (NK) cells act as the host’s first line of immunosurveillance, and their maturation and effector functions are finely regulated by multiple factors. Although histone deacetylase (HDAC) inhibition has been reported to im…
Inflammaging is a chronic, low-grade, sterile inflammation associated with aging that contributes to age-related diseases and functional decline. Recent research suggests that targeting inflammaging through senolytics, metabolic modulators, microbiome-based interventions, and lifestyle modifications may help improve healthspan, reduce chronic disease burden, and promote healthy aging. ABSTRACT Inflammaging, defined as the persistent, low-grade sterile inflammation accompanying … Read more
Mucosal Immunol. 2026 Jul 26:100391. doi: 10.1016/j.mucimm.2026.100391. Online ahead of print. ABSTRACT Bacille Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB) but provides inconsistent protection against disease. Alveolar macrophages (AM) are widely considered the primary myeloid mediators of BCG-induced lung immunity, whereas the contribution of lung interstitial macrophages (IM) remains poorly defined. Here, … Read more
Ryanodine receptor 1 (RyR1) is a key intracellular Ca2+ release channel primarily expressed in skeletal muscle, but also in some immune cells. Gain-of-function RYR1 mutations are the most common cause of the pharmacogenetic disorder malignant hyperther…
T cell-directed immunotherapies have transformed the treatment of hematological malignancies, but durable benefit remains limited by relapse, poor persistence, incomplete immune reconstitution and infection. These outcomes depend not only on target-ant…
Epstein-Barr virus-induced gene 3(EBI3) is conventionally viewed as a subunit of IL-27 and IL-35, yet the function of uncomplexed “free” EBI3 is unknown. We show that free EBI3 is an autonomous immunosuppressive cytokine that acts via a gp130/WSX-1/STA…
