Seminars in Immunology

Semin Immunol. 2024 Oct 1;73:101887. doi: 10.1016/j.smim.2024.101887. Online ahead of print. ABSTRACT The sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of receptors expressed widely on cells of the hematopoietic system. Siglecs recognize terminal sialic acid residues on glycans and often initiate intracellular signaling upon ligation. Cells can express several Siglec family members concurrently with … Read more

Semin Immunol. 2024 Mar;72:101866. doi: 10.1016/j.smim.2024.101866. Epub 2024 Mar 5. NO ABSTRACT PMID:38442534 | DOI:10.1016/j.smim.2024.101866

Semin Immunol. 2024 Mar;72:101864. doi: 10.1016/j.smim.2024.101864. Epub 2024 Jan 31. ABSTRACT Our current understanding of whether B cell involvement in the tumor microenvironment benefits the patient or the tumor – in distinct cancers, subcohorts and individual patients – is quite limited. Both statements are probably true in most cases: certain clonal B cell populations contribute … Read more

Semin Immunol. 2024 Sep 27;73:101888. doi: 10.1016/j.smim.2024.101888. Online ahead of print. NO ABSTRACT PMID:39340930 | DOI:10.1016/j.smim.2024.101888

Semin Immunol. 2024 Jun 13;73:101886. doi: 10.1016/j.smim.2024.101886. Online ahead of print. NO ABSTRACT PMID:38875768 | DOI:10.1016/j.smim.2024.101886

Semin Immunol. 2024 Jun 10;73:101884. doi: 10.1016/j.smim.2024.101884. Online ahead of print. ABSTRACT Infection with SARS-CoV-2 in humans has caused a pandemic of unprecedented dimensions. SARS-CoV-2 is primarily transmitted through respiratory droplets and targets ciliated epithelial cells in the nasal cavity, trachea, and lungs by utilizing the cellular receptor angiotensin-converting enzyme 2 (ACE2). The innate immune … Read more

Semin Immunol. 2024 May 23;73:101885. doi: 10.1016/j.smim.2024.101885. Online ahead of print. ABSTRACT The gut microbiota is well known to possess immunomodulatory capacities, influencing a multitude of cellular signalling pathways to maintain host homeostasis. Although the formation of the immune system initiates before birth in a sterile environment, an emerging body of literature indicates that the … Read more

Semin Immunol. 2024 Apr 12;73:101883. doi: 10.1016/j.smim.2024.101883. Online ahead of print. NO ABSTRACT PMID:38613999 | DOI:10.1016/j.smim.2024.101883

Semin Immunol. 2024 Mar;72:101874. doi: 10.1016/j.smim.2024.101874. Epub 2024 Mar 19. ABSTRACT Carcinogenesis in the process of long-term co-evolution of tumor cells and immune environment essentially becomes possible due to incorrect decisions made, remembered, and reproduced by the immune system at the level of clonal populations of antigen-specific T- and B-lymphocytes. Tumor-immunity interaction determines the nature … Read more

Semin Immunol. 2024 Mar;72:101875. doi: 10.1016/j.smim.2024.101875. Epub 2024 Mar 14. ABSTRACT The integration of multi-‘omic datasets into complex systems-wide assessments has become a mainstay in immunologic investigation. This focus on high-dimensional data collection and analysis was on full display in the investigation of COVID-19, the respiratory illness resulting from infection by the novel coronavirus SARS-CoV-2. … Read more