Trends in Immunology

Trends Immunol. 2025 Mar 19:S1471-4906(25)00054-7. doi: 10.1016/j.it.2025.02.011. Online ahead of print. ABSTRACT Microglia, key orchestrators of the brain’s immune responses, play a pivotal role in the progression of Alzheimer’s disease (AD). Emerging human models, including stem cell-derived microglia and cerebral organoids, are transforming our understanding of microglial contributions to AD pathology. In this review, we … Read more

Trends Immunol. 2025 Mar 18:S1471-4906(25)00056-0. doi: 10.1016/j.it.2025.02.013. Online ahead of print. ABSTRACT IFN-γ is a pleiotropic antiviral cytokine that coordinates innate and adaptive immune responses and induces both immunostimulatory and immunosuppressive activities, limiting its use in the clinic. Due to its antiviral role, several viruses express proteins that bind IFN-γ, blocking its interaction with the … Read more

Trends Immunol. 2025 Mar 12:S1471-4906(25)00032-8. doi: 10.1016/j.it.2025.02.005. Online ahead of print. ABSTRACT Patients with an inborn error of immunity (IEI) often show a complete penetrance of their disease-causing mutation, whereas other forms of IEI show a family pattern where many family members carrying the same mutation remain unaffected. The underlying mechanism, differential allele-specific expression, was … Read more

Trends Immunol. 2025 Mar 10:S1471-4906(25)00024-9. doi: 10.1016/j.it.2025.01.006. Online ahead of print. ABSTRACT Arthritis is associated with varying degrees of intestinal inflammation and microbiota dysbiosis, leading to the ‘gut-joint axis hypothesis’ in which intestinal and joint inflammation are suggested to be interconnected through immune-microbiota interactions. While clinical observations support this, causality remains uncertain. Rodent models have … Read more

Trends Immunol. 2025 Mar 5:S1471-4906(25)00033-X. doi: 10.1016/j.it.2025.02.006. Online ahead of print. ABSTRACT Supporting emerging immunologists in Latin America and the Caribbean (LAC) is crucial amidst fragile funding and policy shifts in the region. Their growth can deliver region-specific health solutions, foster pandemic preparedness, and advance neglected tropical disease research, paying it forward to reduce health … Read more

Trends Immunol. 2025 Mar 5:S1471-4906(25)00035-3. doi: 10.1016/j.it.2025.02.008. Online ahead of print. ABSTRACT The mammalian inflammasome is crucial for responding to environmental/intrinsic stress, and its regulation remains a significant focus in immune-mediated inflammatory diseases and antitumor immunity. Recent studies highlight a close link between palmitoylation and inflammasome regulation. However, this type of regulation remains elusive but … Read more

Trends Immunol. 2025 Mar 4:S1471-4906(25)00026-2. doi: 10.1016/j.it.2025.01.008. Online ahead of print. ABSTRACT IFI27, an interferon (IFN)-stimulated gene, is emerging as a crucial player in immune responses across various species, with significant implications for precision medicine. Commonly found among the most upregulated genes in infections, cancers, as well as inflammatory and autoimmune disorders, IFI27 is ready … Read more

Trends Immunol. 2025 Feb 28:S1471-4906(25)00034-1. doi: 10.1016/j.it.2025.02.007. Online ahead of print. ABSTRACT Sleep is a major driver of waste clearance from the brain, but the mechanisms underpinning brain cleansing during sleep, which are also important for immunological functions, are poorly understood. Recent mouse work by Hauglund et al. shows how oscillatory surges in norepinephrine (NE) … Read more

Trends Immunol. 2025 Feb 28:S1471-4906(25)00029-8. doi: 10.1016/j.it.2025.02.002. Online ahead of print. ABSTRACT Lymph node (LN) fibroblastic reticular cells (FRCs) are key regulators of mammalian adaptive immune responses. Together with their deposited extracellular matrix (ECM), FRCs form a reticular network that provides mechanical strength to LNs. Furthermore, the ECM regulates various cell functions including proliferation and … Read more

Trends Immunol. 2025 Feb 26:S1471-4906(25)00031-6. doi: 10.1016/j.it.2025.02.004. Online ahead of print. ABSTRACT Lytic cell death is crucial for antimicrobial and antitumor immunity; however, unchecked pyroptosis drives pathology in sepsis. Wright et al. demonstrate that widespread cell death following pyroptosis is propagated by extracellular vesicles (EVs) carrying gasdermin D (GSDMD) pores that become integrated into the … Read more