Trends in Immunology

Trends Immunol. 2024 Sep 21:S1471-4906(24)00190-X. doi: 10.1016/j.it.2024.08.004. Online ahead of print. ABSTRACT The importance of neuroinflammation in neurodegenerative diseases is becoming increasingly evident, and, in parallel, human induced pluripotent stem cell (hiPSC) models of physiology and pathology are emerging. Here, we review new advancements in the differentiation of hiPSCs into glial, neural, and blood-brain barrier … Read more

Trends Immunol. 2024 Sep 27:S1471-4906(24)00212-6. doi: 10.1016/j.it.2024.09.004. Online ahead of print. ABSTRACT Kloosterman and colleagues studied molecular and cellular changes during radiation therapy and disease recurrence across molecular subtypes of glioblastoma. They uncovered a distinct immune-cancer cell metabolic crosstalk during proneural/oligodendrocyte progenitor cell-like to mesenchymal-like transition, wherein macrophages feed on cholesterol-rich myelin debris to provide … Read more

Trends Immunol. 2024 Sep 27:S1471-4906(24)00194-7. doi: 10.1016/j.it.2024.08.008. Online ahead of print. ABSTRACT The astrocyte, a major glial cell type in the central nervous system (CNS), is widely regarded as a functionally diverse mediator of homeostasis. During development and throughout adulthood, astrocytes have essential roles, such as providing neuron metabolic support, modulating synaptic function, and maintaining … Read more

Trends Immunol. 2024 Sep 26:S1471-4906(24)00215-1. doi: 10.1016/j.it.2024.09.007. Online ahead of print. ABSTRACT The recent study by Ryu et al. demonstrates that the SARS-CoV-2 Spike protein binds fibrin(ogen), impacting coagulation and immune responses in mice. In this spotlight article we focus on the described effects on natural killer (NK) cell responses as well as the suggested … Read more

Trends Immunol. 2024 Sep 25:S1471-4906(24)00214-X. doi: 10.1016/j.it.2024.09.006. Online ahead of print. ABSTRACT Extrahepatic, cell-autonomous, and/or intracellularly active complement components are increasingly recognized as key orchestrators of cell physiological processes. A recent study by Scott-Hewitt et al. demonstrates that microglia-derived C1q unexpectedly associates with the ribosomes of neurons in the aging murine brain, where it impacts … Read more

Trends Immunol. 2024 Sep 25:S1471-4906(24)00213-8. doi: 10.1016/j.it.2024.09.005. Online ahead of print. ABSTRACT Cancers hijack the nervous system for growth and spread. Thus, disrupting neuron-cancer crosstalk holds promise for blocking metastasis. Recently, Padmanaban et al. reported new therapeutic targets and showed that breast cancer cells activate sensory neurons to secrete the neuropeptide substance P (SP), leading … Read more

Trends Immunol. 2024 Sep 25:S1471-4906(24)00211-4. doi: 10.1016/j.it.2024.09.003. Online ahead of print. ABSTRACT Thromboinflammation is a peculiar and key component of acute COVID-19 pathogenesis, which contributes to long COVID. In a recent study, Ryu et al. demonstrate that the SARS-CoV-2 spike protein interacts with fibrinogen, promoting fibrin polymerization and its inflammatory activity. Targeting the inflammatory fibrin … Read more