Trends Immunol. 2026 Jun 9:S1471-4906(26)00131-6. doi: 10.1016/j.it.2026.05.006. Online ahead of print. ABSTRACT Immunity and metabolism are deeply intertwined in maintaining homeostasis. With the recognition of cytosolic dsDNA sensing as an initiator of immune responses, its interface with metabolic rewiring has emerged as a key area of investigation. Focusing on the stimulator of interferon genes adaptor … Read more
Trends Immunol. 2026 Jun 9:S1471-4906(26)00132-8. doi: 10.1016/j.it.2026.05.007. Online ahead of print. ABSTRACT Pancreatic cancer is a deadly disease defined by an immunosuppressive microenvironment refractory to therapy. Kiemen et al. applied 3D histology, imaging mass cytometry, and spatially resolved DNA sequencing to human pancreata containing early precursors of the disease, revealing heterogeneous and mutation-specific inflammatory niches … Read more
Trends Immunol. 2026 Jun 9:S1471-4906(26)00128-6. doi: 10.1016/j.it.2026.05.003. Online ahead of print. ABSTRACT Tissue-resident macrophages exhibit remarkable plasticity, dynamically adapting to their local environment and adopting tissue-specific phenotypes that support organ homeostasis. The underlying identity-determining transcriptional programs are instructed by microenvironmental cues. Transforming growth factor-β (TGF-β), which has long been recognized for its role in immunosuppression, … Read more
Trends Immunol. 2026 Jun 5:S1471-4906(26)00127-4. doi: 10.1016/j.it.2026.05.002. Online ahead of print. ABSTRACT Neutrophil asthma is a severe, corticosteroid-resistant subtype characterized by airway neutrophilia and declining lung function. Su et al. identify a sirtuin 6-lactate dehydrogenase A-histone lactylation axis that links macrophage glycolysis to epigenetic chemokine regulation, offering mechanistic insight into neutrophil recruitment and highlighting potential … Read more
Trends Immunol. 2026 May 28:S1471-4906(26)00100-6. doi: 10.1016/j.it.2026.04.007. Online ahead of print. NO ABSTRACT PMID:42209365 | DOI:10.1016/j.it.2026.04.007
Trends Immunol. 2026 May 28:S1471-4906(26)00099-2. doi: 10.1016/j.it.2026.04.006. Online ahead of print. NO ABSTRACT PMID:42209364 | DOI:10.1016/j.it.2026.04.006
Trends Immunol. 2026 May 27:S1471-4906(26)00096-7. doi: 10.1016/j.it.2026.04.003. Online ahead of print. ABSTRACT Antimicrobial resistance (AMR) is one of today’s most worrisome health emergencies. Bacteria, once easily treatable with antibiotics, have acquired resistance to many or all available drugs. In 2019, 1.27 million infection-related deaths were directly caused by AMR. By 2050, AMR could put 10 … Read more
Trends Immunol. 2026 May 25:S1471-4906(26)00104-3. doi: 10.1016/j.it.2026.04.011. Online ahead of print. ABSTRACT Substance use disorders are traditionally conceptualized as disorders of brain reward circuitry; however, accumulating evidence demonstrates that addictive substances exert profound and persistent effects on central and peripheral immune and inflammatory systems. Opioids, psychostimulants, alcohol, nicotine, cannabinoids, and psychedelics modulate immune signaling across … Read more
Trends Immunol. 2026 May;47(5):339. doi: 10.1016/j.it.2026.03.012. NO ABSTRACT PMID:42167144 | DOI:10.1016/j.it.2026.03.012
Trends Immunol. 2026 May;47(5):343-344. doi: 10.1016/j.it.2026.03.014. NO ABSTRACT PMID:42167146 | DOI:10.1016/j.it.2026.03.014
