Trends in Immunology

Trends Immunol. 2025 Mar 4:S1471-4906(25)00026-2. doi: 10.1016/j.it.2025.01.008. Online ahead of print. ABSTRACT IFI27, an interferon (IFN)-stimulated gene, is emerging as a crucial player in immune responses across various species, with significant implications for precision medicine. Commonly found among the most upregulated genes in infections, cancers, as well as inflammatory and autoimmune disorders, IFI27 is ready … Read more

Trends Immunol. 2025 Feb 28:S1471-4906(25)00034-1. doi: 10.1016/j.it.2025.02.007. Online ahead of print. ABSTRACT Sleep is a major driver of waste clearance from the brain, but the mechanisms underpinning brain cleansing during sleep, which are also important for immunological functions, are poorly understood. Recent mouse work by Hauglund et al. shows how oscillatory surges in norepinephrine (NE) … Read more

Trends Immunol. 2025 Feb 28:S1471-4906(25)00029-8. doi: 10.1016/j.it.2025.02.002. Online ahead of print. ABSTRACT Lymph node (LN) fibroblastic reticular cells (FRCs) are key regulators of mammalian adaptive immune responses. Together with their deposited extracellular matrix (ECM), FRCs form a reticular network that provides mechanical strength to LNs. Furthermore, the ECM regulates various cell functions including proliferation and … Read more

Trends Immunol. 2025 Feb 26:S1471-4906(25)00031-6. doi: 10.1016/j.it.2025.02.004. Online ahead of print. ABSTRACT Lytic cell death is crucial for antimicrobial and antitumor immunity; however, unchecked pyroptosis drives pathology in sepsis. Wright et al. demonstrate that widespread cell death following pyroptosis is propagated by extracellular vesicles (EVs) carrying gasdermin D (GSDMD) pores that become integrated into the … Read more

Trends Immunol. 2025 Feb 25:S1471-4906(25)00027-4. doi: 10.1016/j.it.2025.01.009. Online ahead of print. ABSTRACT Helper innate lymphoid cells (ILCs), comprising groups ILC1, ILC2, and ILC3, possess unique advantages in eliciting rapid immune responses and were recently found to exhibit direct tumor-killing capacities comparable with those of cytotoxic ILCs [natural killer (NK) cells] in humans and mice. Although … Read more

Trends Immunol. 2025 Feb 25:S1471-4906(25)00030-4. doi: 10.1016/j.it.2025.02.003. Online ahead of print. ABSTRACT Osteoimmunology is an interdisciplinary branch of immunology studying bidirectional interactions between the immune and skeletal systems. Bone marrow is vital for the production of immune cells and is implicated in multiple diseases across all immunology disciplines. Here, we briefly discuss recent progress from … Read more

Trends Immunol. 2025 Feb 20:S1471-4906(25)00025-0. doi: 10.1016/j.it.2025.01.007. Online ahead of print. ABSTRACT Fevers are an ancient feature of the inflammatory microenvironment. While fevers may improve the immune response to pathogens, mechanisms are unclear. We explore recent studies of how fever-range temperatures inform mammalian T cell metabolism, differentiation, and stress responses. Recent evidence indicates that metabolic … Read more

Trends Immunol. 2025 Feb 15:S1471-4906(25)00028-6. doi: 10.1016/j.it.2025.02.001. Online ahead of print. NO ABSTRACT PMID:39956713 | DOI:10.1016/j.it.2025.02.001

Trends Immunol. 2025 Feb 12:S1471-4906(24)00309-0. doi: 10.1016/j.it.2024.12.007. Online ahead of print. ABSTRACT Decidual stromal cells (DSCs) are involved in immunoregulatory mechanisms that prevent fetal rejection by the mammalian maternal immune system. Recent studies using single-cell RNA sequencing demonstrated the existence of different types of human and mouse DSCs, highlighting corresponding differentiation (decidualization) pathways, and suggesting … Read more

Trends Immunol. 2025 Jan 30:S1471-4906(25)00021-3. doi: 10.1016/j.it.2025.01.003. Online ahead of print. ABSTRACT The adaptor protein mitochondrial antiviral signaling protein (MAVS)-mediated innate immune response is essential for host defense against RNA viruses. Gokhale and colleagues report that cellular mRNAs assemble and activate the MAVS signalosome by directly binding to MAVS and regulating its interactors, consequently enhancing … Read more