With global population aging, senescence has emerged as a key driver of tumorigenesis. Aging-associated molecular changes, including DNA damage, telomere shortening, and epigenetic dysregulation, increase malignancy, while immunosenescence and the sene…
The emerging field of biomimetic microfluidics is advancing the engineering of immune-competent Organs-on-Chips. These systems overcome the constraints of conventional models by using precise microengineering to regulate cellular composition, three-dim…
Recent breakthroughs in molecular vaccinology have defined a new generation of vaccines that integrate synthetic mRNA, self-amplifying RNA, and nanomaterial-based platforms. These fourth-generation vaccines offer exceptional adaptability, rapid design,…
Effective tissue repair after acute myocardial infarction (MI) critically depends on the timely and orderly resolution of inflammation. This review systematically elaborates the core “directorial” role of efferocytosis—the immunologically silent cleara…
Cytokine inducible SH2-containing protein (CISH) was the founding member of the suppressor of cytokine signaling (SOCS) family of negative regulators. However, the subsequent elucidation of the physiological roles of CISH has been a slow process, refle…
Atherosclerosis (AS) is a leading cause of cardiovascular events and mortality worldwide. Plaque stability is a direct determinant of clinical outcomes for patients. Within the hypoxic and inflammatory microenvironment of plaques, glycolysis is signifi…
Implanting biomaterials gives rise to the foreign body response (FBR), a complex cascade consisting of blood-material interactions, provisional matrix formation, inflammation, wound healing, and remodeling. While tissue engineering seeks to harness thi…
Crimean-Congo- Hemorrhagic Fever (CCHF) is the most widespread tick-borne disease in the world with a highly variable case fatality rate. It is caused by the CCHF virus (CCHFV). The disease, which has neither approved treatments nor vaccines, has long …
The impaired healing of diabetic wounds is closely associated with a persistent inflammatory response, wherein macrophages, as crucial immune effector cells in the local wound microenvironment, play a vital role in maintaining inflammatory equilibrium….
Ileostomy is extensively utilized as a preventive method to avert anastomotic leakage and other severe complications in colorectal surgery, serving as a valuable model for both study and clinical applications. The ileostoma, as a window, allows for the…
