BackgroundNeurosyphilis, as a serious infectious disease caused by Treponema pallidum invading the central nervous system, has seen a significant increase in global incidence in recent years. However, the trends and gaps in the research of neurosyphili…
IntroductionToll-like receptors (TLRs) are transmembrane proteins essential for innate immunity. While vertebrate TLRs have been well studied, knowledge of their distribution, structure, and function in mollusks remains limited, despite their importanc…
ObjectiveOvarian cancer is a common malignant tumor of the female reproductive system, and traditional treatments are unsatisfactory due to its intraperitoneal spreading mechanism and its biologic characteristic of being prone to drug resistance. Pembr…
BackgroundThis study aims to comprehensively analyze the independent risk factors of postherpetic neuralgia (PHN) through a systematic evaluation, including demographic characteristics, clinical manifestations, treatment regimens, comorbidities, and vi…
BackgroundImmune checkpoint inhibitors (ICIs)-based neoadjuvant therapy has been regulatory approved in clinical practice since 2021. However, it is still difficult to determine which patients can benefit from it. Here, we conducted a meta-analysis to …
BackgroundExisting research presents conflicting findings on how baseline lung immune prognostic index (LIPI), lactate dehydrogenase (LDH), and derived neutrophil-to-lymphocyte ratio (dNLR) levels influence the prognosis of patients with extensive-stag…
IntroductionThe shortage of suitable donor organs represents an ongoing global challenge for organ transplantation. During the COVID-19 pandemic, the number of transplantable organs was especially limited. To date, the impact of recent coronavirus-19 (…
BackgroundRelapsed/refractory follicular lymphoma (R/R FL) remains a significant challenge in oncology, particularly for patients who have exhausted standard treatment options. Both chimeric antigen receptor (CAR) T-cell therapy and bispecific antibodi…
ObjectivesThe immunomodulatory properties of traditional Chinese medicine (TCM) have attracted significant attention as a strategy for addressing viral infections. However, a comprehensive bibliometric analysis is still lacking. This study aims to syst…
BackgroundImmune checkpoint inhibitors (ICIs) redefined the treatment of non-small cell lung cancer (NSCLC) but their efficacy in elderly and frail patients remains unclear due to immune-senescence and the underrepresentation of these populations in cl…
