BackgroundAlterations of the gut microbiome are well documented in connective tissue diseases, whereas the oral microbiome has largely been studied in isolation. Emerging evidence suggests coordinated dysbiosis across mucosal sites with oral-gut reloca…
BackgroundOsteonecrosis (ON) is a prevalent and severe complication in patients with systemic lupus erythematosus (SLE). However, the etiology and mechanism of SLE-ON have not been fully elucidated. This study aims to investigate the factors related to…
ObjectivesTo define the current evidence for CAR-based cellular therapy in relapsed or refractory systemic lupus erythematosus (SLE) by resolving overlapping reports and synthesising patient-level phenotype, safety and efficacy data. The primary purpos…
BackgroundAllogeneic hematopoietic stem cell transplantation (HSCT) has markedly improved survival in children with primary immunodeficiencies (PIDs) transforming previously fatal diseases into curable conditions. As survival improves late effects are …
ObjectiveThis study aimed to systematically evaluate the bidirectional association between obstructive lung diseases (OLD) [including chronic obstructive pulmonary disease (COPD), asthma, and bronchiectasis] and inflammatory bowel disease (IBD) [includ…
BackgroundMitochondrial transfer has emerged as an important form of intercellular communication with growing relevance to immune regulation, inflammation, tissue repair, and tumor immunity. However, the knowledge structure, developmental trajectory, a…
BackgroundThe Systemic Immune-Inflammation Index (SII), a composite biomarker integrating neutrophil, platelet, and lymphocyte counts, has been increasingly investigated in thyroid cancer. However, its diagnostic accuracy and association with lymph nod…
IntroductionPancreatic ductal adenocarcinoma (PDAC) exhibits a profoundly immunosuppressive tumor microenvironment, with tumor-associated macrophages (TAMs) being the most abundant immune infiltrate. Among them, lipid-associated macrophages (LAMs) have…
BackgroundSystemic Lupus Erythematosus (SLE) is a systemic autoimmune disease that may damage multiple organs. About one-third of SLE patients have ocular manifestations. SLE as a potential risk factor for glaucoma has attracted attention, but existing…
ObjectiveExtracellular vesicles (EVs) are cell-derived, membrane-bound particles that have gained increasing attention for their roles in pathophysiology, diagnostics, and targeted therapies. This review aimed at systematically collecting and criticall…
