BackgroundThe immune microenvironment of head and neck squamous cell carcinoma (HNSCC) is highly complex, and the mechanisms underlying interactions between natural killer (NK) cells and tumor-associated macrophages (TAMs) remain unclear. This study in…
Cancer remains the leading cause of death worldwide. Despite decades of continuous research, limitations persist in existing therapeutic approaches. Conventional strategies such as surgery, chemotherapy, and radiotherapy, though advanced, face challeng…
IntroductionSkin protects the body from external threats by constituting an epithelial–immune microenvironment. Sulfotransferase family 2B member 1 (SULT2B1) converts cholesterol to cholesterol sulfate (CS). We previously reported that CS acts as an en…
ObjectiveTo identify biomarkers and endotypes predictive of treatment response, monitor disease activity, and explore pathways associated with the clinical efficacy of leflunomide and hydroxychloroquine combination therapy (LEF/HCQ) in patients with pr…
Cancer remains a leading cause of mortality worldwide, with rising incidence and death rates continuing to rise. While conventional treatments such as surgery, radiotherapy, and chemotherapy form the backbone of cancer care, they are often limited by a…
BackgroundOsteoarthritis, a common degenerative osteochondral disease, has a close relationship between its mechanism of Macrophage polarization. However, there are relatively few relevant studies in this field, and a more mature research system has no…
ObjectivesThis meta-analysis evaluated the direction and strength of associations between air pollution, emerging chemical pollutants, and systemic lupus erythematosus (SLE) incidence, clarifying distinct relationships by pollutant type.MethodBy utiliz…
ObjectLiver fibrosis is a key stage in chronic liver disease, but targeted treatments are scarce. Pien Tze Huang (PZH), a traditional Chinese medicine, shows anti-fibrotic potential, though its mechanisms are not fully understood.MethodA liver fibrosis…
