BackgroundPathological response after neoadjuvant chemotherapy is a key treatment milestone in osteosarcoma. We evaluated whether a rule-derived preoperative peripheral inflammatory-lymphocyte recovery phenotype constructed from routinely collected lab…
Bullous Pemphigoid (BP) is the most common autoimmune blistering disorder, predominantly affecting elderly patients and often requiring prolonged immunosuppression. Conventional therapies are frequently limited by adverse effects and incomplete disease…
Kawasaki disease (KD) is an acute systemic vasculitis that can affect multiple organs. Kawasaki disease shock syndrome (KDSS) is a severe complication of KD. Pulmonary involvement is uncommon in KD, and there are very few reports of patients with KD wh…
Mitophagy serves as a pivotal metabolic-immune hub that drives immune evasion in major skin cancer subtypes including melanoma cutaneous squamous cell carcinoma and basal cell carcinoma. It acts as a core barrier to effective immunotherapy. Mitophagy a…
IntroductionOnly a subset of epithelial cells can initiate progressive lung adenocarcinoma (LUAD), yet the founder cell states that confer this competence remain poorly defined.MethodsWe established a barcoded KrasG12D, Trp53 loss mouse LUAD organoid m…
Hepatocellular carcinoma (HCC) commonly develops in the context of chronic liver injury and fibrosis, and its immune evasion and therapeutic resistance are shaped not only by tumor-intrinsic factors but also by persistent interactions between the tumor…
BackgroundThe tumor microenvironment (TME) of gastric adenocarcinoma is exceptionally heterogeneous, and epithelial-mesenchymal transition (EMT) is a central mechanism promoting local invasion and metastatic spread. Even so, how EMT-programmed cells ar…
Programmed death 1 (PD-1) inhibitors have transformed the treatment of advanced non-small cell lung cancer (NSCLC), but durable responses remain limited to a subset of patients. Conventional biomarkers, including PD-L1 expression and tumor mutational b…
Atopic dermatitis is a chronic inflammatory skin disease characterized by type 2 immune responses and severe itching; however, the molecular mechanisms linking lipid metabolism to epithelial–immune signaling remain incompletely understood. Herein, we s…
BackgroundAcute myeloid leukemia (AML) shows substantial biological and clinical heterogeneity that extends beyond leukemia-intrinsic genetic alterations. MRC1, which encodes the myeloid receptor CD206, has been linked to monocytic differentiation and …
