Genome-wide association studies have linked CARS2 locus, encoding the mitochondrial cysteinyl aminoacyl-tRNA synthetase CARS2, to coronary artery disease. Moreover, we previously demonstrated that CARS2 suppression was associated with a pro-inflammator…
BackgroundAnti-metabotropic glutamate receptor 5 (mGluR5) encephalitis is a rare autoimmune neurological disorder with high clinical heterogeneity. The phenotypic spectrum of anti-mGluR5 autoimmune encephalitis (AE) and the relationship between MRI fin…
Tissue remodeling refers to the structural and functional alterations an organ undergoes in response to changing environmental conditions. This process is precisely regulated by complex signaling networks. While these networks are essential for physiol…
Every year, approximately 13 million infants are born preterm (
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection and is a leading cause of death in critically ill patients. Studies have shown that immune dysfunction plays a central role in the pathogenesis …
Eosinophils have long been recognized as terminal effector cells in type 2 immunity; however, emerging evidence positions them as central regulators of intestinal homeostasis, immune modulation, and tissue adaptation. This review provides a comprehensi…
Gram-negative bacteria are clinically significant pathogens responsible for life-threatening infections, including respiratory infections. These can be acute or persistent and can exacerbate existing chronic diseases, such as cystic fibrosis, COPD and …
IntroductionIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease characterized by persistent inflammation, aberrant extracellular matrix remodeling, and impaired tissue repair. Current antifibrotic drugs can slow disease progress…
Allergic rhinitis (AR) is an IgE-dependent, Th2 cell-mediated disorder that significantly impairs patients’ quality of life. In recent years, molecular innate immune regulation has emerged as a pivotal area of research, especially focusing on the use o…
BackgroundPostherpetic neuralgia (PHN) is the most common and severe complication of herpes zoster (HZ), and early identification of high-risk patients remains a major clinical challenge. The systemic inflammatory response index (SIRI) is a novel infla…
