ObjectiveThe objective was to investigate the association between tonsillectomy and subsequent ankylosing spondylitis (AS) risk, with particular emphasis on racial disparities in disease susceptibility.MethodsA retrospective cohort study was conducted …
BackgroundT-cell engagers (TCEs), “off-the-shelf” immunotherapies are seeing widespread clinical application, yet their real-world safety profile is not fully defined. This study aimed to characterize the comprehensive adverse event (AE) profile of TCE…
The impaired healing of diabetic wounds is closely associated with a persistent inflammatory response, wherein macrophages, as crucial immune effector cells in the local wound microenvironment, play a vital role in maintaining inflammatory equilibrium….
ObjectiveTo assess the clinical relevance of diagnosing and classifying isolated IgG deficiency and combined IgG/IgM deficiency separately from CVID.MethodsIn a retrospective cohort of patients with primary hypogammaglobulinemia, we evaluated and compa…
Ileostomy is extensively utilized as a preventive method to avert anastomotic leakage and other severe complications in colorectal surgery, serving as a valuable model for both study and clinical applications. The ileostoma, as a window, allows for the…
IntroductionMetastatic recurrence drives dismal survival in esophageal squamous cell carcinoma (ESCC), yet epigenetic mechanisms underlying metastasis remain poorly defined. While DNMT1 and DNMT3A contribute to ESCC pathogenesis, DNMT3B’s role is enigm…
BackgroundTuberculosis (TB) remains a leading opportunistic infection in immunocompromised hosts. Disruption of host–pathogen interactions under cumulative immunosuppression may result in atypical extrapulmonary disease with indolent clinical manifesta…
