How distinct hematopoietic waves generate specialized macrophage lineages remains unclear. Chen et al. identify separate transcriptional pathways controlling macrophage development during primitive versus definitive hematopoiesis and identify Maf and J…
CCR7+ dendritic cells (DCs) are pivotal for antitumor immunity. Zitti, Duval et al. find that intratumoral CCR7+ DCs form perivascular hubs dependent on CCL19-CCR7 signaling. Regulatory T cells (Tregs) restrain immune function within these hubs, and bo…
Huang et al. study the heterogeneity of regulatory T (Treg) cells in a genetic model of colorectal cancer (CRC) and find that interleukin (IL)-10− Treg cells promote tumor progression, whereas IL-10+ Treg cells restrain tumor growth by suppressing IL-1…
Monocyte-derived macrophages are highly plastic, whereas tissue-resident macrophages resist inflammatory reprogramming. Verwaerde et al. show that tissue-resident alveolar macrophages can be reprogrammed during type 2 pulmonary immune responses by acti…
Immune cells must modulate their metabolism to adapt to tissue constraints. Wientjens et al. show that allergen-induced ILC2s and Th2 cells require cysteine-driven glutathione synthesis to prevent ferroptosis and support lipid metabolism. This redox ba…
Blocking pathogenic T cell migration is crucial for treating autoimmune diseases. Li et al. reveal SUB1 as a gatekeeper of CD4+ T cell infiltration in autoimmunity. TCR-induced SUB1 drives Rac-dependent cytoskeletal remodeling via DOCK2 transcriptional…
Tumor necrosis factor (TNF), type I interferons (IFNs), and autophagy are important biological processes, but their interactions in inflammation have not been explored. In this issue of Immunity, Priem et al. reveal that ATG9A-mediated autophagy curbs …
TET2 mutations can drive clonal hematopoiesis (CH), but their impact on tumor immunity remains unresolved. Recently in Cancer Cell, Herbrich et al. reported that TET2-mutant CH reprograms tumor-associated macrophages to enhance antigen presentation and…
The seminal discoveries that established the role of regulatory T cells in immunological tolerance were recognized by this year’s Nobel Prize in Physiology or Medicine. Benoist and colleagues discuss the unfolding of the Treg story, the players involve…
The initial responses of microglia to neuronal stress or altered network activity are poorly characterized. Xie and colleagues show that during TDP-43-related neurodegeneration, microglia detect early neuronal hyperactivity and transition into a distin…
