inmunoadmin

The neuroendocrine peptide catestatin promotes clearance of cutaneous Staphylococcus aureus through mast cell Mrgpr activation. Colin Guth

by

Mucosal Immunol. 2026 Mar 3:S1933-0219(26)00027-9. doi: 10.1016/j.mucimm.2026.03.003. Online ahead of print. ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of cutaneous infections, underscoring the need for alternative therapeutic strategies. Catestatin (CST), a neuroendocrine antimicrobial peptide produced by neurons and epithelial cells, has been implicated in skin defense against pathogens such as MRSA, though its … Read more

Secondary bile acids as immune and metabolic mediators. Stefano Fiorucci

by

Trends Immunol. 2026 Mar 3:S1471-4906(25)00316-3. doi: 10.1016/j.it.2025.12.008. Online ahead of print. ABSTRACT Bile acids are cholesterol derivatives, generated by the coordinated intervention of human and bacterial genes, functioning as endogenous ligands for multiple transcription factors and receptors throughout the body. While only two primary bile acids are generated by the human liver, the intestinal microbiota … Read more

Amyloid precursor protein is a subunit of microglial Hv1 channels

by

Curr Opin Immunol. 2026 Mar 3;100:102751. doi: 10.1016/j.coi.2026.102751. Online ahead of print. ABSTRACT Voltage-gated proton channels (Hv1) are key regulators of microglial activation, coupling proton extrusion to reactive oxygen species production, cellular pH homeostasis, and pro-inflammatory signaling. Dysregulated Hv1 activity exacerbates neuroinflammation and contributes to a range of central nervous system pathologies. Our recent work … Read more

Clinical trials and new therapies in Sjögren’s disease

by

Curr Opin Immunol. 2026 Mar 3;100:102743. doi: 10.1016/j.coi.2026.102743. Online ahead of print. ABSTRACT Despite major advances in understanding Sjögren’s disease (SjD), no approved disease-modifying therapies have been approved. Management remains largely symptomatic with the use of off-label immunomodulators for systemic features. This gap highlights the substantial unmet need for targeted treatment. Encouragingly, the therapeutic landscape … Read more

Targeting synovial fibroblast KCa1.1 channels in rheumatoid arthritis

by

Curr Opin Immunol. 2026 Mar 3;100:102747. doi: 10.1016/j.coi.2026.102747. Online ahead of print. ABSTRACT Fibroblast-like synoviocytes (FLS) play major roles in the pathogenesis of rheumatoid arthritis (RA). Human and rat FLS express the KCa1.1 channel (BK, Maxi-K, Slo1, and KCNMA1) as their major potassium channel at the plasma membrane. Reducing the expression or function of this … Read more

Beyond ion flux: the potassium channel KV1.3 and its regulatory function in neutrophils

by

Curr Opin Immunol. 2026 Mar 3;100:102750. doi: 10.1016/j.coi.2026.102750. Online ahead of print. ABSTRACT The voltage-gated potassium channel KV1.3 (KCNA3) is a critical ion channel regulating membrane potential in immune cells, facilitating sustained calcium influx and activating downstream signaling events. Besides its canonical role as an ion channel, KV1.3 has been postulated to exert additional functions … Read more

Response of B cells specific for polyomavirus-derived oncoprotein is predictive of Merkel cell carcinoma tumor control

by

Cancer Immunol Res. 2026 Mar 4. doi: 10.1158/2326-6066.CIR-25-0950. Online ahead of print. ABSTRACT Merkel cell carcinomas (MCC) typically arise from clonal integration of the Merkel cell polyomavirus. Immunogenic viral oncoproteins then lead to tumorigenesis. Oncoprotein-specific T cells are essential for anti-MCC immunity, but it is unclear whether B cells promote tumor control. Here, we analyzed … Read more

The CNC-bZIP transcription factor Nrf2 controls expression of matrix metalloproteases in murine macrophages​Abel D Ang on 4 de March de 2026 at 11:00

by

J Leukoc Biol. 2026 Mar 3;118(3):qiag021. doi: 10.1093/jleuko/qiag021. ABSTRACT Liver fibrosis is a chronic condition that often leads to organ failure. Currently, no effective treatment exists for advanced liver fibrosis. De-repression of the transcription factor Nrf2, by inhibition of the ubiquitin ligase substrate adaptor Keap1, is a promising strategy to treat liver fibrosis because Nrf2 … Read more

HER2-Specific Synthetic Antigen Receptor (SAR) T Cell Therapy Synergizes with Radiotherapy to Provide Improved Anti-Tumor Efficacy in Non-Small Cell Lung Cancer (NSCLC)​Olga-Demetra Biziotis on 4 de March de 2026 at 11:00

by

J Leukoc Biol. 2026 Mar 3:qiag030. doi: 10.1093/jleuko/qiag030. Online ahead of print. ABSTRACT In NSCLC, radiotherapy mediates cytotoxicity but also activates radioresistance drivers like HER2. We investigated radiotherapy combined with HER2-targeted T cell therapy in a NSCLC model. The anti-tumor efficacy of radiotherapy and engineered T cells expressing a DAP12-associated synthetic antigen receptor (SAR) targeting … Read more

deneme bonusu veren siteler - canlı bahis siteleri - casino siteleri casino siteleri deneme bonusu veren siteler canlı casino siteleri error code: 520