inmunoadmin

Immunoregulatory Functions of the ER Stress Sensor IRE1 in Myeloid Cell Biology​Alonso Lira on 18 de October de 2025 at 10:00

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J Leukoc Biol. 2025 Oct 17:qiaf145. doi: 10.1093/jleuko/qiaf145. Online ahead of print. ABSTRACT Myeloid cells- including monocytes, macrophages, dendritic cells (DCs), and granulocytes constitute a versatile arm of the immune system, serving as frontline sentinels that detect and react to environmental cues and orchestrate tailored immune responses. Their ability to respond promptly to distinct threats … Read more

Short‐Chain Fatty Acid Sodium Butyrate Suppresses Protective Humoral Immunity by Inhibiting Follicular T Helper Cell Differentiation. [[{“value”:”Bhushan Nikam, Someshwar Nath Jha, Yatish Thakare, Poonam Coshic, Nimesh Gupta”}]]

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We show that sodium butyrate suppresses Tfh-cell differentiation, via HDAC inhibition, leading to inefficient germinal center responses and impaired antibody generation. This suboptimal humoral immunity fails to confer protection against virus infection, underscoring sodium butyrate’s potential impact on shaping GC-derived protective immunity. ABSTRACT The gut microbiome and its metabolites are critical regulators of intestinal homeostasis, … Read more

T follicular helper cells drive functionally distinct lymphoid and lung resident germinal centres and limit allergic airway disease. Faith I Uwadiae

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Mucosal Immunol. 2025 Oct 15:S1933-0219(25)00107-2. doi: 10.1016/j.mucimm.2025.10.005. Online ahead of print. ABSTRACT T follicular helper cells (TFH) play a central role in orchestrating antibody mediated immunity. Despite the importance of antibody responses, especially allergen-specific IgE, in allergic airway diseases (AAD) such as asthma, the precise role TFH play in AADs has remained elusive. Using a … Read more

Three’s company: The cooperative signals behind the differentiation of Th9 cells. J Alejandra Rodriguez

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Semin Immunol. 2025 Oct 16;80:101999. doi: 10.1016/j.smim.2025.101999. Online ahead of print. ABSTRACT T helper 9 (Th9) cells, characterized by their production of interleukin-9 (IL-9), play pivotal roles in protective immunity and inflammatory disease. Their differentiation depends on the integration of three signals: TCR engagement (Signal 1), co-stimulatory receptor activation (Signal 2), and cytokine-driven transcriptional programming … Read more

Mycobacterium tuberculosis-specific blood immune signatures distinguish sarcoidosis from tuberculosis disease

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J Immunol. 2025 Oct 17:vkaf274. doi: 10.1093/jimmun/vkaf274. Online ahead of print. ABSTRACT Sarcoidosis is a granulomatous systemic inflammatory disease predominantly affecting the lungs. It shares histopathological, clinical, and immune features with tuberculosis (TB). There are currently no diagnostic tests to formally identify sarcoidosis; instead, there is a need first to rule out the presence of … Read more

RNA helicase DDX3X promotes NK cell survival by supporting MCL1 expression

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J Immunol. 2025 Oct 16:vkaf281. doi: 10.1093/jimmun/vkaf281. Online ahead of print. ABSTRACT DDX3 and other DEAD-box RNA helicases regulate nuclear export, translation, splicing, and metabolism of RNA. Perturbation of Ddx3x on the mouse X-chromosome in all hematopoietic cells resulted in a loss of natural killer (NK) cells, yet whether DDX3X is important only in progenitors … Read more

eEF2K promotes immune evasion in melanoma via Cyclin D1-mediated stabilization of PD-L1

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J Immunol. 2025 Oct 16:vkaf278. doi: 10.1093/jimmun/vkaf278. Online ahead of print. ABSTRACT Eukaryotic elongation factor 2 kinase (eEF2K) is a stress-responsive regulator of protein synthesis implicated in melanoma progression, but its role in tumor immune evasion remains poorly defined. We investigated how eEF2K influences programmed death ligand 1 (PD-L1) expression through modulation of Cyclin D1. … Read more

Antiviral responses in peripheral and brain neurons

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Curr Opin Immunol. 2025 Oct 14;97:102678. doi: 10.1016/j.coi.2025.102678. Online ahead of print. ABSTRACT Neurotropic viruses represent a public health challenge due to their ability to cause severe neurological conditions, including meningitis, encephalitis, and paralysis. Although many studies have investigated the immune responses to viral infections in the brain and other nervous system targets, most have … Read more

Stool Screening for Campylobacter Species in Hypogammaglobulinemic Patients Receiving Immunoglobulin Therapy

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J Clin Immunol. 2025 Oct 16;45(1):143. doi: 10.1007/s10875-025-01949-0. ABSTRACT Hypogammaglobulinemia (HG) predisposes patients to gastrointestinal Campylobacter infections. This prospective study determined the prevalence of Campylobacter in stool samples from patients with immunoglobulin (Ig)-substituted HG at Bordeaux University Hospital. 73 patients (42 women, median age: 61) receiving Ig substitution therapy were enrolled from July 2022 to … Read more

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