inmunoadmin

Single cell atlas of lung-resident innate lymphoid cells shows impact of age and dysbiosis on epigenetic and transcriptomic programming. Madeline Bonfield

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Mucosal Immunol. 2026 Jan 17:S1933-0219(26)00004-8. doi: 10.1016/j.mucimm.2026.01.004. Online ahead of print. ABSTRACT The mechanisms underlying innate lymphoid cell (ILC) development and function in the neonatal lung remain incompletely defined. ILCs are critical mediators of early-life innate immune responses in the lung. Dysregulation of ILC homeostasis has both immediate and long-lasting effects on lung health. We … Read more

Basal activation of ERK1/2 blunts the antimicrobial activity of neutrophils from old hosts against antibody-opsonized Streptococcus pneumoniae​Shaunna R Simmons on 19 de January de 2026 at 11:00

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J Leukoc Biol. 2026 Jan 19:qiag011. doi: 10.1093/jleuko/qiag011. Online ahead of print. ABSTRACT Age-related decline in neutrophil function reduces vaccine protection against Streptococcus pneumoniae. In vaccinated hosts, neutrophil activation via complement and Fcγ receptors mediates bacterial uptake and killing. Mechanisms behind age-related changes in signaling of these receptors is unknown. Using neutrophils from young and … Read more

Sirtuin 1 is an endogenous NETosis inhibitor that becomes dysfunctional in diabetes​Liang De Wang on 19 de January de 2026 at 11:00

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J Leukoc Biol. 2026 Jan 19:qiag006. doi: 10.1093/jleuko/qiag006. Online ahead of print. ABSTRACT Neutrophils release their chromatin with toxic granular proteins as neutrophil extracellular traps (NETs) when activated. Diabetes exacerbates NET formation (NETosis), resulting in tissue damage and diabetic complications such as non-healing wounds. How diabetes predisposes neutrophils to NETosis remains unclear. Herein, we found … Read more

IL-11 acts as an alarmin-like pro-inflammatory mediator regulating mucosal responses during helminth infection. Pedro H Gazzinelli-Guimaraes

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Mucosal Immunol. 2026 Jan 16:S1933-0219(26)00005-X. doi: 10.1016/j.mucimm.2026.01.005. Online ahead of print. ABSTRACT Lung-trafficking helminth larvae drive an early pulmonary neutrophilic inflammation prior to the establishment of the hallmark Type 2 immune response. While IL-11 is known to play crucial roles in chronic inflammatory responses, its role in the mucosal immunity to helminth parasites has not … Read more

FAM83H Regulates Postnatal T Cell Development Through Thymic Stroma Organization. [[{“value”:”Betul Melike Ogan, Veronika Forstlova, Laura Jane Dowling, Michaela Simova, Kristina Vicikova, Vendula Novosadova, Frantisek Spoutil, Sylvie Cervenkova, Michaela Procházková, Jolana Tureckova, Olha Fedosieieva, Juraj Labaj, Petr Nickl, Kamila Krizova, Jan Prochazka, Jana Balounova, Radislav Sedlacek”}]]

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Loss of the casein kinase 1 scaffolding protein FAM83H compromises bone marrow lymphopoiesis, reduces Foxn1 expression in cortical thymic epithelial cells (TEC), disrupts thymic architecture and TEC identity, and ultimately impairs double-negative thymocyte proliferation and T-cell production. ABSTRACT Family of Sequence Similarity 83H (FAM83H/SACK1H) is primarily expressed in epithelial cells, where it interacts with casein … Read more

Shared HLA‐E and Mamu‐E Peptide Repertoires With Subtle Peptide Binding Differences Revealed by Combined nDSF‐ and Fluorescence Polarisation‐Based Methods. [[{“value”:”Max N. Quastel, Sashini A. Ranawana, Bas W. A. Peeters, Andy van Hateren, Andrew J. McMichael, Geraldine M. Gillespie”}]]

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The MHC-E peptide binding methods described here—nano-differential scanning fluorimetry and fluorescence polarisation—demonstrate shared peptide binding repertoires with subtle binding hierarchy differences for the tested HLA-E and Mamu-E allotypes. When combined, these methods illustrate how minor MHC-E-peptide thermal stability changes equate to significant binding strength differences. ABSTRACT The primary function of MHC-E—human leukocyte antigen (HLA)-E in … Read more

ICAM-1 and vascular matrices coordinate skin S1-macrophage formation from blood PDGFRα-lineage monocyte​Yu-Tung Li on 16 de January de 2026 at 11:00

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J Leukoc Biol. 2026 Jan 17:qiaf185. doi: 10.1093/jleuko/qiaf185. Online ahead of print. ABSTRACT Extravasation control of leukocytes and their functional fates are crucial to maintain tissue homeostasis. Leukocyte lineage origin regulates these processes that blood monocytes derived from PDGFRα+ embryonic progenitors (PDGFRα-lineage) extravasate more efficiently to inflamed skin than non-PDGFRα-lineage cells. Here we elucidated the … Read more

Optimizing patient-reported outcomes for sarcoidosis

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Curr Opin Immunol. 2026 Jan 14;99:102720. doi: 10.1016/j.coi.2025.102720. Online ahead of print. ABSTRACT Patients with sarcoidosis can present with a wide range of symptoms that impact their quality of life (QoL). QoL represents one of the most important treatment priorities for patients. Therefore, measuring what matters to patients is of great importance, though it can … Read more

A conserved upstream element in the mouse Csf1r locus contributes to transcription in hematopoietic and trophoblast cells​Emma Maxwell on 16 de January de 2026 at 11:00

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J Leukoc Biol. 2026 Jan 16:qiag004. doi: 10.1093/jleuko/qiag004. Online ahead of print. ABSTRACT Expression of the Csf1r gene in mice is restricted to cells of the mononuclear phagocyte system and placental trophoblasts. A conserved element (Csf1r upstream regulatory element A, CUREA) in the mouse Csf1r locus contains transcription start sites utilised by trophoblasts and osteoclasts … Read more

Conditional IL4I1 inactivation triggers tumor-associated macrophage reprogramming and CD8+ T-cell reactivation to control melanoma progression

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Cancer Immunol Res. 2026 Jan 15. doi: 10.1158/2326-6066.CIR-24-1159. Online ahead of print. ABSTRACT Tumor-associated macrophages (TAMs) represent the main immune population infiltrating cancers, and their abundance is generally correlated with a poor prognosis. The acquisition of protumor properties by TAMs involves several mechanisms, including expression of immunosuppressive enzymes. In this study, we explored the role … Read more

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