inmunoadmin J Immunol. 2025 Jul 29:vkaf172. doi: 10.1093/jimmun/vkaf172. Online ahead of print. ABSTRACT As we age, it becomes increasingly important to reduce the consumption of fatty foods. In mice, we also find that after consuming a high-fat diet, older mice develop insulin resistance more easily than young mice. But how aging renders both humans and mice … Read more
Curr Opin Immunol. 2025 Jul 28;96:102618. doi: 10.1016/j.coi.2025.102618. Online ahead of print. ABSTRACT As with all autoimmune diseases, antineutrophil cytoplasmic autoantibody (ANCA) vasculitis cannot be cured by a singular approach. This complexity arises because autoimmune conditions typically result from multiple hits to the immune system – including genetic predisposition, environmental exposures, infections, and perturbations in … Read more
Curr Opin Immunol. 2025 Jul 28;96:102616. doi: 10.1016/j.coi.2025.102616. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) is a leading cause of irreversible central vision loss in elderly populations across developed countries. Complement system dysregulation has been implicated in AMD onset and evolution. Complement inhibition therapies have been authorized in the USA as the primary … Read more
J Immunol. 2025 Jul 28:vkaf153. doi: 10.1093/jimmun/vkaf153. Online ahead of print. ABSTRACT Uterine natural killer cells have been thought to be critical for reproductive success, and their developmental origins remain unclear. Here, we demonstrate that Eomesodermin is a key transcription factor determining the lineage of tissue-resident NK cells within the uterus both at steady state … Read more
J Clin Immunol. 2025 Jul 29;45(1):118. doi: 10.1007/s10875-025-01913-y. ABSTRACT Natural Killer (NK) cells naturally recognize and eliminate leukemic cells. However, the molecular interactions that govern these responses are diverse due to the large number of activating and inhibitory NK receptors that modulate NK functions and the diversity of corresponding ligands that are differentially expressed in … Read more
In a patient with the classical clinical phenotype of STAT3-hyper-IgE syndrome, we identified the previously unreported STAT3 variant p.K709N to be disease-causing. Molecular analyses revealed that STAT3 p.K709N exerts a dominant-negative effect, leading to impaired STAT3 dimerization and reduced STAT3 target gene expression. Source: Created in BioRender. Hagl B. (2025) https://BioRender.com/80tycxp. ABSTRACT STAT3-hyper-IgE syndrome (STAT3-HIES) … Read more
Schematic diagram of DCpep-NM-PLGA-rOmpW preparation and its immunoprotective effects on acute lethal pneumonia. This study developed a biomimetic nanovaccine (DCpep-NM-PLGA-rOmpW) against A. baumannii. The nanoparticle-delivered multiepitope vaccine induced robust Th1/Th17 and antibody responses, demonstrating significant protection in a lethal pneumonia model. ABSTRACT The development of vaccines represents a promising and safe strategy to combat multidrug-resistant … Read more
Conditionally replicating oncolytic adenoviruses (OAds) mediate cancer cell destruction while triggering robust immune responses. Clinical data reveal their ability to remodel the tumor microenvironment and enhance responsiveness when combined with other therapies. This review highlights immune-modulating effects of OAds in patients, with a focus on therapeutic implications and combination strategies. ABSTRACT Oncolytic immunotherapy, particularly using … Read more
The immunodominant pan-coronavirus epitope iCope spans amino acids 816–830 within the fusion domain of the SARS-CoV-2 spike glycoprotein. This region exhibits a comparatively low mutation rate, especially when contrasted with the receptor-binding domain (RBD). Antigen-specific T cell responses against iCope are detectable even in unexposed individuals, are modestly enhanced following SARS-CoV-2 infection, and are robustly … Read more
Mucosal Immunol. 2025 Jul 26:S1933-0219(25)00077-7. doi: 10.1016/j.mucimm.2025.07.006. Online ahead of print. ABSTRACT The nasal, oropharyngeal, and bronchial mucosa are primary contact points for airborne pathogens like Mycobacterium tuberculosis (Mtb), SARS-CoV-2, and influenza virus. While mucosal surfaces can function as both entry points and barriers to infection, mucosa-associated lymphoid tissues (MALT) facilitate early immune responses to … Read more
