inmunoadmin

Virus-specific memory CD4 T cells sustain long-term numerical and functional impairment following whole-body irradiation

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J Immunol. 2026 Aug 29;215(9):vkag244. doi: 10.1093/jimmun/vkag244. ABSTRACT The increasing demand for nuclear power and radiotherapy has expanded potential avenues for human exposure to whole-body irradiation (WBI), underscoring the need to understand its impact on immune cells. While prior studies have explored radiation-induced disruptions in immune homeostasis, the direct effect of WBI on pre-existing memory … Read more

Mucosal-associated invariant T cells respond to colonic microbiome alterations during acute HIV infection. Sinmanus Vimonpatranon

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Mucosal Immunol. 2026 Sep 10:100403. doi: 10.1016/j.mucimm.2026.100403. Online ahead of print. ABSTRACT Mucosal-associated invariant T (MAIT) cells are an unconventional subset of T cells that respond to vitamin B2 metabolites from a range of bacteria and fungi. We have previously reported that peripheral MAIT cells are activated during acute HIV infection (AHI) in a manner … Read more

Eating to heal: dietary interventions as emerging immune-based therapeutic strategies. Wenyu Cui

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Trends Immunol. 2026 Sep 9:S1471-4906(26)00227-9. doi: 10.1016/j.it.2026.08.011. Online ahead of print. ABSTRACT Clinical immunology is increasingly recognizing diet not merely as baseline metabolic sustenance but as a tunable pharmacological tool. By targeting conserved nutrient-sensing networks and the microbiome, defined nutritional protocols-such as fasting mimetics and specific macronutrient titrations-can actively rewire immune responses. In this review, … Read more

Leukocyte immunoglobulin-like receptor A3 inhibits the activity of immunosuppressive myeloid cells

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Cancer Immunol Res. 2026 Sep 9. doi: 10.1158/2326-6066.CIR-26-0070. Online ahead of print. ABSTRACT Myeloid checkpoint blockade as monotherapy often yields limited benefit, suggesting that multiple inhibitory pathways cooperatively sustain myeloid immunosuppression in the tumor microenvironment (TME). However, strategies to concurrently target multiple myeloid checkpoints remain challenging. Leukocyte immunoglobulin-like receptor A3 (LILRA3) is a soluble LILRA/B … Read more

Estrogen receptor beta limits T cell-mediated inflammation to maintain immune homeostasis

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J Immunol. 2026 Aug 29;215(9):vkag238. doi: 10.1093/jimmun/vkag238. ABSTRACT Many autoimmune diseases exhibit a female sex bias in prevalence and severity, yet the mechanisms for this remain unclear. 17β-estradiol (E2) is a steroid sex hormone with established immunomodulatory roles in CD4+ T cells, which express the nuclear estrogen receptors ERα and ERβ. Autoimmune disease patients exhibit … Read more

Autologous Glypican-3-Targeted, Armored CAR T Cells in Patients with Advanced Solid Tumors: A Phase 1 Dose-Escalation Study of TAK-102

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Cancer Immunol Res. 2026 Sep 8. doi: 10.1158/2326-6066.CIR-25-0855. Online ahead of print. ABSTRACT Chimeric antigen receptor (CAR) T-cell therapies have shown limited promise in solid tumors owing to the immunosuppressive tumor microenvironment. TAK-102 is a next-generation, glypican-3 (GPC3)-targeted CAR T-cell therapy engineered to co-express interleukin-7 (IL-7) and chemokine ligand 19 (CCL19), enhancing T-cell survival and … Read more

Single-Cell and Spatial Transcriptomics Define Eosinophil Heterogeneity during Influenza A Virus-induced Exacerbation of Fungal Allergic Asthma in C57BL/6 mice​Anthony J Veltri on 8 de September de 2026 at 10:00

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J Leukoc Biol. 2026 Sep 8:qiag120. doi: 10.1093/jleuko/qiag120. Online ahead of print. ABSTRACT Although eosinophils are accepted as transcriptionally heterogeneous in asthma, how allergic inflammation shapes eosinophil states during influenza A virus (IAV) infection remains undefined. We integrated high-resolution single-cell RNA sequencing, spatial transcriptomics, quantitative immunofluorescence imaging, and cell-cell communication analyses to profile murine lungs … Read more

Tumor-associated neutrophils and macrophages differentially affect T cell biology in the head and neck cancer tumor microenvironment​Xi Wang on 8 de September de 2026 at 10:00

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J Leukoc Biol. 2026 Sep 8:qiag122. doi: 10.1093/jleuko/qiag122. Online ahead of print. ABSTRACT Intra-tumoral T cell activity is required for effective anti-tumor immune responses and is partly regulated by tumor-associated neutrophils and macrophages. Here, we investigated the spatial context of neutrophil/macrophage interactions with CD8+ T cells in head and neck squamous cell carcinoma. Using multiplex … Read more

SHIP1 Restrains Hypoxia/Reoxygenation‐Induced Cytokine Secretion in Mouse Bone Marrow–Derived Mast Cells. [[{“value”:”Lara Gubeljak, Jonas Pes, Eren Arik, Aaron T. Fehr, Mara Schietinger, Thomas Wilhelm, Sandro Capellman, Michael Huber, Pardes Habib”}]]

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(A) BMMCs are substantially more resistant to oxygen deprivation than neurons, microglia, oligodendrocytes, astrocytes, and fibroblasts. (B) Role of SHIP-1 in primary mouse bone marrow mast cells’ hypoxia response. Under hypoxia, SHIP-1 induces cytokine release. SHIP1 restrains hypoxia/reoxygenation-induced cytokine secretion in BMMCs via the RAS/ RAF, HIF1α, and PI3K/AKT pathways. The graphical abstract was prepared … Read more

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