inmunoadmin

The Antigen Presenting Capabilities of Group 3 Innate Lymphoid Cells: Insights Into Immunogenic or Tolerogenic Outcomes for T Cells. [[{“value”:”Alessia Calabrò, Sayuri Yamazaki, Guido Ferlazzo, Stefania Campana”}]]

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The Janus face of group 3 innate lymphoid cells (ILC3s). ILC3s are highly plastic and can adapt their immunoregulatory roles according to the local context, balancing tolerance and activation. Influenced by tissue-specific environmental cues, they can express MHC class II molecules either alone or jointly with costimulatory molecules, therefore presenting acquired antigens for controlling or … Read more

A novel mechanism of immunoevasion by ER+ breast cancer. Claudia Galassi

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Trends Immunol. 2025 Dec 17:S1471-4906(25)00311-4. doi: 10.1016/j.it.2025.12.003. Online ahead of print. ABSTRACT Estrogen receptor (ER)+ breast malignancies are poorly infiltrated by immune cells, hence exhibiting limited sensitivity to immune checkpoint inhibitors (ICIs). Recent data from Palomeque et al. demonstrate that ER signaling actively contributes to such an immunoevasive phenotype by preventing the nuclear factor LCOR … Read more

Immune cellular homeostasis and its breakdown at the maternal-fetal interface. Nardhy Gomez-Lopez

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Trends Immunol. 2025 Dec 16:S1471-4906(25)00302-3. doi: 10.1016/j.it.2025.11.006. Online ahead of print. ABSTRACT Pregnancy requires dynamic immune adaptations that balance tolerance, homeostasis, and defense at the maternal-fetal interface. Recent advances integrating findings from human placental samples with those from refined animal models now enable a detailed analysis of how cellular responses in mid and late gestation … Read more

New insights into Th9 cells in inflammatory bowel diseases. Markus F Neurath

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Semin Immunol. 2025 Dec 16;81:102013. doi: 10.1016/j.smim.2025.102013. Online ahead of print. ABSTRACT The involvement of T helper cells in the pathogenesis of inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, has been a subject of considerable research interest. The clinical picture of IBD is characterised by chronic intestinal inflammatory processes that may lead … Read more

The role of linked recognition and B cell precursor frequency in alloimmunization to transfused RBCs

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Curr Opin Immunol. 2025 Dec 16;98:102705. doi: 10.1016/j.coi.2025.102705. Online ahead of print. ABSTRACT Despite multiple alloantigenic differences in every allotransfusion, only 3-6% of transfusion recipients develop a detectable alloantibody even with multiple transfusions. Moreover, patients typically become alloimmunized only to some of the alloantigens to which they are exposed. In recent decades, precursor frequency of … Read more

Indole sensing in host, microbiota, and pathogen interactions

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Curr Opin Immunol. 2025 Dec 16;98:102710. doi: 10.1016/j.coi.2025.102710. Online ahead of print. ABSTRACT Indole is an abundant metabolite in the mammalian gut. Both mammals and microorganisms sense it. Indole is a signal used to communicate and gauge the gut environment. Indole is produced by bacteria that encode the tryptophanase enzyme. However, indole sensing is not … Read more

From X-rays to advanced imaging modalities in pulmonary sarcoidosis

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Curr Opin Immunol. 2025 Dec 16;98:102709. doi: 10.1016/j.coi.2025.102709. Online ahead of print. ABSTRACT Sarcoidosis is a multisystem inflammatory disorder characterized by noncaseating epithelioid granulomata, most commonly involving the lungs and thoracic lymph nodes. Although definitive diagnosis relies on tissue biopsy, characteristic findings detected on computed tomography (CT) often allow a confident diagnosis. Atypical imaging patterns, … Read more

Targeting immune heterogeneity in liver metastases through in vivo genetic engineering. Giovanna Giacca

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Semin Immunol. 2025 Dec 15;81:102012. doi: 10.1016/j.smim.2025.102012. Online ahead of print. ABSTRACT The liver is both a central metabolic organ and a uniquely tolerogenic immune niche, which makes it a frequent site of liver metastases (LMS) and a challenging environment for immunotherapy. It is increasingly appreciated that resident liver cells- Kupffer cells, Ito cells, liver … Read more

Single-Cell Transcriptomic Analysis Reveals RNA-Binding Protein Dysregulation in Immune Checkpoint Inhibitor-Induced Colitis​Haobei Ran on 15 de December de 2025 at 11:00

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J Leukoc Biol. 2025 Dec 15:qiaf181. doi: 10.1093/jleuko/qiaf181. Online ahead of print. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy by enhancing anti-tumor immunity, but their use is frequently complicated by immune-related adverse events (irAEs), particularly ICI-induced diarrhea and colitis. Growing evidence suggests that RNA-binding proteins (RBPs), which are critical post-transcriptional regulators of immune … Read more

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