inmunoadmin Cancer Immunol Res. 2026 Aug 26. doi: 10.1158/2326-6066.CIR-25-1589. Online ahead of print. ABSTRACT T-cell immune tolerance is established in part through the activity of the Auto-immune Regulator (AIRE) transcription factor in the medullary thymic epithelial cells (mTEC) of the thymus. AIRE induces expression of peripheral tissue-specific self-antigens for presentation to naïve T cells to promote … Read more
Cancer Immunol Res. 2026 Aug 26. doi: 10.1158/2326-6066.CIR-25-1471. Online ahead of print. ABSTRACT Despite the availability of various treatment modalities for liver cancer, its mortality rate remains high. Immunotherapy represents an emerging approach for liver cancer. However, the response rate to single-agent immune checkpoint blockade therapy is suboptimal. Endoplasmic reticulum oxidoreductase 1-alpha (ERO1A), a potential … Read more
Cancer Immunol Res. 2026 Aug 26. doi: 10.1158/2326-6066.CIR-25-1353. Online ahead of print. ABSTRACT Head and Neck Head and Neck Squamous Cell Carcinoma (HNSCC) is driven by an immunosuppressive tumor microenvironment (TME). We examined the immune-modulatory role of EphA4 in HNSCC using spatial analysis, multi-compartment RNA-sequencing from Oral Cavity Squamous Cell Carcinoma (OCSCC), and three genetically … Read more
Semin Immunol. 2026 Aug 25:102057. doi: 10.1016/j.smim.2026.102057. Online ahead of print. NO ABSTRACT PMID:42642260 | DOI:10.1016/j.smim.2026.102057
Semin Immunol. 2026 Aug 25;83:102055. doi: 10.1016/j.smim.2026.102055. Online ahead of print. ABSTRACT A defining and evolutionary-selected feature of hematopoiesis is its capacity to adapt to organismal cellular needs. This demand-adapted hematopoiesis relies on a complex peripheric immune system capable of sensing minute amounts of damage and pathogen molecular patterns and trigger an inflammation-based reaction that … Read more
Household members of SARS-CoV-2 positive index persons donated a serum sample (t = 0). Within 14 days, the household members reported if COVID-19-like symptoms appeared and returned after 2 weeks to be retested. Serum responses were comprehensively measured and elevated variant-specific IgA1 and neutralizing antibody responses identified in the noninfected group. ABSTRACT Correlates of protection … Read more
Autocrine IL-9 production by ILC2s promotes their expansion and effector responses, including IL-5-driven eosinophilia, in response to airway allergens. In contrast, Th2 cell-intrinsic IL-9R signaling is dispensable for type 2 lung inflammation. Lung monocytes, macrophages, and DCs do not respond to IL-9 in asthma models due to the absence of IL-9R expression. ABSTRACT Interleukin-9 (IL-9) … Read more
We infected Germ-free and normal SPF mice infected with strains of LCMV that cause chronic infections. In both types of mice, T cell exhaustion progressed to similar levels. Thus, the microbiome is dispensable for the induction of T cell exhaustion. ABSTRACT Prolonged antigen exposure in chronic viral infections reduces the effector capacity of cytotoxic T … Read more
GLUT3 is essential for T regulatory (Treg) cell metabolic fitness, supporting both glycolysis and mitochondrial function required for their suppressive activity and effector differentiation. Loss of GLUT3 in Treg cells leads to impaired immune regulation and systemic autoimmunity, highlighting a critical role for glucose uptake in maintaining immune tolerance. ABSTRACT Regulatory T (Treg) cells are … Read more
Staphylococcus aureus skin infection generates long-lived tissue-resident memory T cells that provide enhanced local recall responses to reinfection, leading to improved bacterial clearance. Skin Trm could therefore be a potential correlate of protective immunity and targeted in future vaccine development. ABSTRACT Staphylococcus aureus is a leading cause of skin and soft tissue infections (SSTIs), yet … Read more
