inmunoadmin

Chronological maturation of the skin immune barrier is topographically different. Anikó Kapitány

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Mucosal Immunol. 2025 Mar 28:S1933-0219(25)00030-3. doi: 10.1016/j.mucimm.2025.03.004. Online ahead of print. ABSTRACT Adult skin varies across regions, with differences in chemical, physical, microbiota, and immune barriers. However, data on topographical immune differences in other age groups are limited. This study aimed to explore the chronological maturation of the immune barrier in various skin regions. A … Read more

Single-cell sequencing reveals the same heterogeneity of neutrophils in heatstroke-induced lung and liver injury. Fuquan Wang

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Mucosal Immunol. 2025 Mar 28:S1933-0219(25)00031-5. doi: 10.1016/j.mucimm.2025.03.005. Online ahead of print. ABSTRACT Heatstroke (HS) is typically considered a sepsis-like syndrome caused by hyperthermia, often accompanied by multiple organ dysfunctions (MODS). To explore the mechanisms of MODS, we established a mouse model of HS by exposing mice to a hyperthermic and high-humidity environment. Then, we utilized … Read more

Variable domain glycosylation as a marker and modulator of immune responses: Insights into autoimmunity and B-cell malignancies. Roxane Biersteker

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Semin Immunol. 2025 Mar 29;78:101946. doi: 10.1016/j.smim.2025.101946. Online ahead of print. ABSTRACT Glycosylation of antibodies is essential for shaping immune responses, as it contributes significantly to antibody function and diversity. While immunoglobulin G (IgG) Fc glycosylation is well-characterized, variable domain glycosylation (VDG) introduces an additional and less understood layer of complexity. Notably, VDG is associated … Read more

Interferon regulatory factor 3 beyond innate immunity: Regulation in obesity and metabolic disorders. Heng Li

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Semin Immunol. 2025 Mar 28;78:101948. doi: 10.1016/j.smim.2025.101948. Online ahead of print. ABSTRACT Interferon regulatory factor 3 (IRF3) is a transcription factor known primarily for its role in antiviral immunity via regulation of type I interferons (IFNs). Recent research has broadened its significance to encompass metabolic disorders, particularly obesity and diabetes. Obesity is characterized by chronic … Read more

Enhancing activity of FcαRI-bispecific antibodies using glycoengineering

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J Immunol. 2025 Mar 28:vkaf027. doi: 10.1093/jimmun/vkaf027. Online ahead of print. ABSTRACT Macrophages and natural killer (NK) cells can effectively kill tumor cells in the presence of anti-cancer IgG monoclonal antibodies (mAbs), but neutrophils are less effective. We previously showed that IgG1 bispecific antibodies (BsAb), which target the IgA Fc receptor (FcαRI, CD89) and a … Read more

Cryptococcosis, tuberculosis, and a kidney cancer fail to fit the atherosclerosis paradigm for foam cell lipid content

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J Immunol. 2025 Mar 28:vkaf038. doi: 10.1093/jimmun/vkaf038. Online ahead of print. ABSTRACT Foam cells are dysfunctional, lipid-laden macrophages associated with chronic inflammation of diverse origin. The long-standing paradigm that foam cells are cholesterol-laden derives from atherosclerosis research. We previously showed that, in tuberculosis, foam cells surprisingly accumulate triglycerides. Here, we utilized bacterial (Mycobacterium tuberculosis), fungal … Read more

Temporal Immune Profiling in the CSF and Blood of Patients with Aneurysmal Subarachnoid Hemorrhage​Thomas A Ujas on 28 de March de 2025 at 10:00

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J Leukoc Biol. 2025 Mar 28:qiaf038. doi: 10.1093/jleuko/qiaf038. Online ahead of print. ABSTRACT BACKGROUND: Delayed cerebral ischemia (DCI) is a significant complication of aneurysmal subarachnoid hemorrhage (aSAH). This study profiled immune responses after aSAH and evaluated their association with DCI onset. METHODS: Twelve aSAH patients were enrolled. Leukocyte populations and cytokine levels were analyzed in … Read more

Deciphering SARS-CoV-2 evolution under antibody immune pressure. Fanchong Jian

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Trends Immunol. 2025 Mar 27:S1471-4906(25)00076-6. doi: 10.1016/j.it.2025.03.002. Online ahead of print. ABSTRACT The ongoing evolution of SARS-CoV-2 poses significant challenges to existing neutralizing antibodies and vaccines through immune escape mutations. By leveraging genomic surveillance and antibody deep mutational scanning (DMS) data, Raharinirina and colleagues developed a computational framework to elucidate region-specific SARS-CoV-2 variant dynamics and … Read more

Airway epithelial cells as drivers of severe asthma pathogenesis. Del Dorscheid

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Mucosal Immunol. 2025 Mar 26:S1933-0219(25)00029-7. doi: 10.1016/j.mucimm.2025.03.003. Online ahead of print. ABSTRACT Our understanding of the airway epithelium’s role in driving asthma pathogenesis has evolved over time. From being regarded primarily as a physical barrier that could be damaged via inflammation, the epithelium is now known to actively contribute to asthma development through interactions with … Read more

The immunological processes behind aquaporin 4-antibody seropositive neuromyelitis optica spectrum disorders. Monika Bradl

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Semin Immunol. 2025 Mar 27;78:101945. doi: 10.1016/j.smim.2025.101945. Online ahead of print. ABSTRACT Ever since the discovery of pathogenic aquaporin 4-specific antibodies in the serum of patients with neuromyelitis optica spectrum disorders current knowledge about clinical observations and diagnosis, and about the underlying pathology and resulting therapies have been put forward in excellent reviews and primary … Read more

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