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Neuronal inflammasomes: balancing immunity, neuroinflammation, and homeostasis. Juan Pablo de Rivero Vaccari

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Trends Immunol. 2025 Dec 12:S1471-4906(25)00306-0. doi: 10.1016/j.it.2025.11.007. Online ahead of print. ABSTRACT Recent discoveries reveal that inflammasome signaling in neurons extends beyond host defense to influence fundamental aspects of brain function, including synaptic plasticity, axon remodeling, and exosome-mediated intercellular communication. This review explores how basal neuronal inflammasome activity contributes to central nervous system (CNS) homeostasis … Read more

SLC7A5 regulates B cell metabolism and plasma cell differentiation independent of leucine transport

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J Immunol. 2025 Dec 13:vkaf328. doi: 10.1093/jimmun/vkaf328. Online ahead of print. ABSTRACT B cells play critical roles in humoral immunity to infection, vaccination, and autoimmunity. The differentiation of B cells into antibody-producing plasma cells (PCs) has been extensively studied, but the role of metabolic transporters that mediate nutrient uptake during PC differentiation is not well-understood. … Read more

Recombinant human soluble thrombomodulin prevents murine sclerodermatous chronic graft-versus-host disease

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J Immunol. 2025 Dec 13:vkaf169. doi: 10.1093/jimmun/vkaf169. Online ahead of print. ABSTRACT Chronic graft-versus-host disease (cGVHD) develops with complex interactions between immune cells and cytokines, leading to irreversible fibrosis. Severe cGVHD impairs quality of life and is associated with nonrelapse mortality; however, effective treatments are limited. Recombinant human soluble thrombomodulin (rTM), a novel anticoagulant consisting … Read more

The indole-brain connection: neuroimmune mechanisms and therapy

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Curr Opin Immunol. 2025 Dec 11;98:102708. doi: 10.1016/j.coi.2025.102708. Online ahead of print. ABSTRACT The microbiota-gut-brain axis (MGBA) has been recognized as an important communication network between the gut and the brain. This network operates through immune, neural, and endocrine pathways, wherein microbiota-derived metabolites act as essential messengers regulating MGBA. Among gut metabolites, indole and its … Read more

Salivary gland organoids and the future of modeling autoimmune epithelitis in Sjögren’s disease

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Curr Opin Immunol. 2025 Dec 11;98:102707. doi: 10.1016/j.coi.2025.102707. Online ahead of print. ABSTRACT Sjögren’s disease (SjD) is a systemic autoimmune disorder characterized by a striking tropism for epithelial tissues, particularly the salivary and lacrimal glands. Lack of function of the salivary glands (SGs) leads to a panoply of symptoms, dramatically reducing patient quality of life. … Read more

Tissue signatures of human macrophages during homeostasis and activation

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J Immunol. 2025 Dec 12:vkaf317. doi: 10.1093/jimmun/vkaf317. Online ahead of print. ABSTRACT Human macrophages (MΦs) reside in tissues and develop tissue-specific identities. While studies in mice have identified molecular signatures for site-specific MΦ differentiation, less is known about the transcriptional profiles of human MΦs in distinct sites, including mucosal tissues and lymphoid organs during homeostasis … Read more

Maternal proteome profiling reveals dynamic gestational age-specific responses to de novo vaccination

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J Immunol. 2025 Dec 12:vkaf298. doi: 10.1093/jimmun/vkaf298. Online ahead of print. ABSTRACT Pregnancy is characterized by dynamic immunological adaptations which are essential for maintaining both maternal and fetal health. The first-time use of coronavirus disease 2019 (COVID-19) vaccines in pregnant individuals presented an opportunity to discover pregnancy-specific immunoproteomic signatures across gestation. In this study, we … Read more

Sex-Specific Metabolic Programming in Human Neutrophil Subsets​Anjali S Yennemadi on 12 de December de 2025 at 11:00

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J Leukoc Biol. 2025 Dec 12:qiaf179. doi: 10.1093/jleuko/qiaf179. Online ahead of print. ABSTRACT While sex differences in neutrophil metabolism have been documented, whether this metabolic dimorphism extends to specific neutrophil subsets remains unknown.LDNs are characterized by their lower buoyant density compared to normal-density neutrophils(NDNs), are present in low numbers in healthy individuals, and are often … Read more

TNFR2 Signaling in Musculoskeletal Diseases: Implications for Rheumatoid Arthritis and Osteoarthritis​Emily Qian on 12 de December de 2025 at 11:00

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J Leukoc Biol. 2025 Dec 12:qiaf178. doi: 10.1093/jleuko/qiaf178. Online ahead of print. ABSTRACT Arthritis imposes a substantial global burden and remains without curative therapy. Among the most prevalent forms, rheumatoid arthritis (RA) and osteoarthritis (OA) differ in etiology but converge on pathogenic tumor necrosis factor-α (TNFα) signaling. A key regulatory node is TNFR2, which promotes … Read more

Exploring the Pathogens in Primary Predominantly Antibody Deficiencies of Unknown Genetic Origin

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J Clin Immunol. 2025 Dec 12. doi: 10.1007/s10875-025-01970-3. Online ahead of print. ABSTRACT INTRODUCTION: Primary ‘predominantly antibody deficiencies’ (PADs) are rare disorders characterized by increased susceptibility to infections, autoimmunity, allergies, and malignancies. Their low prevalence and heterogeneity often delay diagnosis, increasing morbidity and mortality. This study identifies infection patterns in PAD patients and analyzes predictors … Read more

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