inmunoadmin

Single‐Cell Profiling Identifies Skin‐Resident Memory CD4+ T Cells as a Potential Correlate of Immunity During Staphylococcus aureus Skin Infection. [[{“value”:”Jonah Clegg, Giovanni Cova, Alberto Carignano, Megan Smith, Emiliano Chiarot, Simona Tavarini, Chiara Sammicheli, Nicholas Rachmaninoff, Serena Vastola, Silvia Guidotti, Emilio Siena, Monia Bardelli, Fabio Bagnoli, Michela Brazzoli, Rachel M. McLoughlin, Elisabetta Soldaini”}]]

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Staphylococcus aureus skin infection generates long-lived tissue-resident memory T cells that provide enhanced local recall responses to reinfection, leading to improved bacterial clearance. Skin Trm could therefore be a potential correlate of protective immunity and targeted in future vaccine development. ABSTRACT Staphylococcus aureus is a leading cause of skin and soft tissue infections (SSTIs), yet … Read more

Zymosan-adjuvanted intranasal norovirus virus-like particle vaccine induces antiviral mucosal immune responses in infant mice. Tomoya Tsuchihashi

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Mucosal Immunol. 2026 Aug 24:100401. doi: 10.1016/j.mucimm.2026.100401. Online ahead of print. ABSTRACT Infants require repeated immunizations of injectable-type vaccines against different pathogens because their immune systems are weaker than those of adults. However, these injectable vaccines cause physical and psychological discomfort. Therefore, there is an urgent need to develop pain-free mucosal vaccines that are optimized … Read more

Identification of an Fgd5-positive subset of iNKT1 cells with enhanced cytotoxicity

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J Immunol. 2026 Aug 4;215(8):vkag199. doi: 10.1093/jimmun/vkag199. ABSTRACT Invariant natural killer T (iNKT) cells are unconventional ɑβ T cells that respond to lipid-based antigens. They play a vital role in response to infections and are involved in diseases such as allergic asthma and cancer. Despite clear immunological roles across multiple diseases, remarkably few tools exist … Read more

ACE2 decoy Fc-fusions and bispecific killer engagers require Fc engagement for in vivo efficacy against SARS-CoV-2

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J Immunol. 2026 Aug 4;215(8):vkag235. doi: 10.1093/jimmun/vkag235. ABSTRACT SARS-CoV-2 has continued to evolve over time, necessitating the adaptation of vaccines to maintain efficacy. Monoclonal antibodies (mAbs) against SARS-CoV-2 were a key line of defense for unvaccinated or immunocompromised individuals. However, these mAbs are now ineffective against current SARS-CoV-2 variants. Here, we tested 3 aspects of … Read more

Invariant chain controls HLA-DQ folding and shapes the HLA class II proxiome

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J Immunol. 2026 Aug 4;215(8):vkag201. doi: 10.1093/jimmun/vkag201. ABSTRACT The invariant chain (Ii) trimerizes in the endoplasmic reticulum and swiftly associates with nascent alpha and beta chains of major histocompatibility complex class II (MHCII) molecules. Ii was ascribed many roles pertaining to the antigen presentation capacity of MHCII molecules. The lack of Ii in knockout mice … Read more

KDM4A promotes microglial pyroptosis and neuropathic pain via the MEG3/SMURF2/HES1 axis

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J Immunol. 2026 Aug 4;215(8):vkag223. doi: 10.1093/jimmun/vkag223. ABSTRACT Neuropathic pain (NP) is a refractory clinical disorder in which microglial pyroptosis plays a crucial role, yet the epigenetic regulation by lysine demethylase 4A (KDM4A) remains unclear. In this study, chronic constriction injury (CCI) rat models were established, and KDM4A was knocked down to evaluate its effects … Read more

Age-related changes in the human T cell receptor alpha repertoire suggest positive selection of dual-specific T cells

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J Immunol. 2026 Aug 4;215(8):vkag214. doi: 10.1093/jimmun/vkag214. ABSTRACT The human T cell receptor (TCR) repertoire is generated in the thymus through a process of recombination involving two gene loci, TRA and TRB, and the pairing of the resulting peptide chains. Because of the lack of allelic exclusion in TRA loci, it is possible for a … Read more

Recombinant SpTrf proteins illustrate putative functions of native SpTrf proteins: from immune response to resolution in sea urchins

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J Immunol. 2026 Aug 4;215(8):vkag213. doi: 10.1093/jimmun/vkag213. ABSTRACT The complex and sophisticated sea urchin innate immune system relies on conserved immune receptor and effector molecules plus the euechinoid-specific Transformer family. Native SpTransformer (natSpTrf) proteins in Strongylocentrotus purpuratus respond to immune challenge by augmenting phagocytosis of microbes. These proteins show significant sequence diversity both within and … Read more

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