inmunoadmin

Intrapulmonary-administered myeloid derived suppressor cells rescue mice from Pseudomonas aeruginosa infection and promote a regulatory/repair phenotype. Maëlys Born-Bony

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Mucosal Immunol. 2025 Mar 17:S1933-0219(25)00027-3. doi: 10.1016/j.mucimm.2025.03.001. Online ahead of print. ABSTRACT Pseudomonas aeruginosa (P.aeruginosa) is a pathogenic opportunistic bacterium, classified as a priority by the WHO for the research of new treatments. As this bacterium is harmful through the inflammation and tissue damage it causes, we investigated the role of Myeloid Derived Suppressor Cells … Read more

JAK Inhibitors and B Cell Function: A Comparative Study of Their Impact on Plasma Cell Differentiation, Cytokine Production, and Naïve B Cell Activation. [[{“value”:”Wenqi Huang, Charlotte de Vries, Ravi Kumar Sharma, Kittikorn Wangriatisak, Katerina Chatzidionysiou, Vivianne Malmström, Caroline Grönwall”}]]

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JAK inhibitors (baricitinib, tofacitinib, upadacitinib), except for filgotinib, significantly reduce plasmablast differentiation but only partly inhibit activation of naïve B cells and exert a more modest effect on TNF and IL-8 production. Unlike other JAK inhibitors, filgotinib selectively inhibits STAT5 phosphorylation without affecting STAT3 phosphorylation in response to IL-21. ABSTRACT B cells play a crucial … Read more

A Mouse Model for Generation of Gut Lamina Propria Plasma Cells Specific for a Deamidated Gluten Peptide. [[{“value”:”Runa I. Løberg, Alisa E. Dewan, Liv Kleppa, M. Fleur du Pré, Ludvig M. Sollid”}]]

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The 1E03 immunoglobulin knock-in mouse produces B cells reactive to deamidated gluten peptides (DGP). The transfer of DGP-specific B cells and immunization with a DGP-cholera toxin conjugate led to the formation of DGP-reactive small-intestinal lamina propria plasma cells and serum antibodies. This model enables studies of plasma cells associated with celiac disease. ABSTRACT Celiac disease … Read more

Cellular immune changes during severe antisense oligonucleotide-associated thrombocytopenia in a nonhuman primate model

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J Immunol. 2025 Mar 18:vkae055. doi: 10.1093/jimmun/vkae055. Online ahead of print. ABSTRACT Antisense oligonucleotides (ASOs) are a new class of single-stranded DNA-based drugs that hold great therapeutic potential. A low incidence of severe, dose-dependent, and reversible thrombocytopenia (TCP) (platelets < 50 K/μl) has been reported in nonhuman primate (NHP) populations, following treatment of monkeys with … Read more

CD209d/e are required for macrophage-mediated phagocytosis and activation during methicillin-resistant Staphylococcus aureus pulmonary host defense

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J Immunol. 2025 Mar 18:vkae061. doi: 10.1093/jimmun/vkae061. Online ahead of print. ABSTRACT Staphylococcus aureus is a commensal and opportunist pathogen of the upper respiratory tract. The recognition of pathogen-associated molecular patterns through pattern-recognition receptors is crucial for eliminating microorganisms such as S. aureus. DC-SIGN (CD209) is a pattern-recognition receptor that binds to a broad range … Read more

Cathelicidin-related antimicrobial peptide (CRAMP) is toxic during neonatal murine influenza virus infection

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J Immunol. 2025 Mar 18:vkae053. doi: 10.1093/jimmun/vkae053. Online ahead of print. ABSTRACT Respiratory viral infections are a major contributor to mortality in children under 5 years of age, and disproportionately affect preterm neonates. Previously, using our established 3-day-old neonatal murine model of influenza virus infection, we demonstrated that treatment of neonatal mice with intranasal Lactobacillus … Read more

A genetically modulated Toll-like receptor-tolerant phenotype in peripheral blood cells of children with multisystem inflammatory syndrome

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J Immunol. 2025 Mar 18:vkaf006. doi: 10.1093/jimmun/vkaf006. Online ahead of print. ABSTRACT Dysregulated innate immune responses contribute to multisystem inflammatory syndrome in children (MIS-C), characterized by gastrointestinal, mucocutaneous, and/or cardiovascular injury occurring weeks after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure. To investigate innate immune functions, we stimulated ex vivo peripheral blood cells from … Read more

Using structure-function information from IFN-γ-binding proteins and biased agonists to uncouple immunostimulatory and immunosuppressive activities. Lucas Mendes-Monteiro

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Trends Immunol. 2025 Mar 18:S1471-4906(25)00056-0. doi: 10.1016/j.it.2025.02.013. Online ahead of print. ABSTRACT IFN-γ is a pleiotropic antiviral cytokine that coordinates innate and adaptive immune responses and induces both immunostimulatory and immunosuppressive activities, limiting its use in the clinic. Due to its antiviral role, several viruses express proteins that bind IFN-γ, blocking its interaction with the … Read more

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