inmunoadmin J Immunol. 2025 Mar 14:vkae068. doi: 10.1093/jimmun/vkae068. Online ahead of print. ABSTRACT The virtually monomorphic antigen presentation molecule HLA-E can present self- and non-self peptides to the NKG2A/CD94 co-receptor inhibitory complex expressed on natural killer (NK) cells and to T cell receptors (TCRs) expressed on T cells. HLA-E presents self-peptides to NKG2A/CD94 to regulate tissue … Read more
Cancer Immunol Res. 2025 Mar 14:OF1-OF2. doi: 10.1158/2326-6066.CIR-25-0202. Online ahead of print. ABSTRACT Biomarkers of responsiveness to immune checkpoint blockade (ICB) are heavily sought given the breadth and depth of the use of ICB in cancer. PD-L1 expression was among the first biomarkers identified, but multiple factors have precluded more widespread use. In this issue, … Read more
Cancer Immunol Res. 2025 Mar 14:OF1-OF20. doi: 10.1158/2326-6066.CIR-24-0151. Online ahead of print. ABSTRACT Immunotherapies have had unprecedented success in the treatment of multiple cancer types, albeit with variable response rates. Unraveling the complex network of immune cells within the tumor microenvironment (TME) may provide additional insights to enhance antitumor immunity and improve clinical response. Many … Read more
J Leukoc Biol. 2025 Mar 14:qiaf026. doi: 10.1093/jleuko/qiaf026. Online ahead of print. ABSTRACT Systemic autoinflammatory diseases (SAIDs) are rare conditions resulting from innate immune system dysregulation, culminating in repetitive bouts of systemic inflammation without the presence of external or self-antigens. Most SAIDs are associated with mutations in genes affecting the innate immune response. Tumor necrosis … Read more
J Leukoc Biol. 2025 Mar 14:qiaf029. doi: 10.1093/jleuko/qiaf029. Online ahead of print. ABSTRACT Differential diagnosis of immune-related adverse events (irAEs) or bacterial infections is sometimes very difficulty in cancer patients undergoing treatment with PD-(L)1 inhibitors. This study aimed to assess the effectiveness of the neutrophil-to-lymphocyte ratio (NLR) in distinguishing between irAEs and bacterial infections in … Read more
Trends Immunol. 2025 Mar 12:S1471-4906(25)00032-8. doi: 10.1016/j.it.2025.02.005. Online ahead of print. ABSTRACT Patients with an inborn error of immunity (IEI) often show a complete penetrance of their disease-causing mutation, whereas other forms of IEI show a family pattern where many family members carrying the same mutation remain unaffected. The underlying mechanism, differential allele-specific expression, was … Read more
J Clin Immunol. 2025 Mar 14;45(1):81. doi: 10.1007/s10875-025-01862-6. ABSTRACT PURPOSE: To investigate the efficacy, safety, tolerability, and serum IgG trough levels of hyaluronidase-facilitated subcutaneous immunoglobulin (fSCIG) 10% in US pediatric patients with primary immunodeficiency diseases (PIDDs). METHODS: This phase 3, open-label, prospective study (NCT03277313) was conducted at 17 US centers. Eligible patients aged 2 to … Read more
A mutation was identified in 47% of the CVID-enrolled patients and, in the majority, it was not related to CVID according to the IUIS classification, leading to a diagnostic metamorphosis of this pathological entity. The Mo-CVID Score could help clinicians prioritize genetic analysis in pediatric CVID patients. The image was created with BioRender.com. ABSTRACT Common … Read more
J Immunol. 2025 Mar 13:vkaf001. doi: 10.1093/jimmun/vkaf001. Online ahead of print. ABSTRACT Type 1 innate lymphoid cells (ILC1s) respond to infections and tumors by producing IFN-γ. Although RAR-related orphan receptor α (RORα) is required for ILC2s and some ILC3s, its role in ILC1 development remains controversial. To investigate the role of RORα in ILC1s, we … Read more
Multicolor spectral flow cytometry panels for cytokine expression analysis were optimized and validated without animal testing. Stimulated co-cultures of helper T cells, splenocytes, and fibroblast-like synoviocytes provided a complex cellular environment suitable for validating intracellular cytokine staining. This approach offers a more ethical alternative to commonly used animal disease models. ABSTRACT Intracellular cytokine labeling combined … Read more
