inmunoadmin

Deciphering the therapeutic potential of Myeloid-Specific JAK2 inhibition in acute respiratory distress syndrome. Shupei Gao

by

Mucosal Immunol. 2024 Aug 21:S1933-0219(24)00089-8. doi: 10.1016/j.mucimm.2024.08.008. Online ahead of print. ABSTRACT Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by severe inflammation and pulmonary dysfunction. Despite advancements in critical care, effective pharmacological interventions for ARDS remain elusive. While Janus kinase 2 (JAK2) inhibitors have emerged as an innovative treatment for numerous autoinflammatory … Read more

CSF1R inhibition by PLX5622 reduces pulmonary fungal infection by depleting MHCIIhi interstitial lung macrophages. Sally H Mohamed

by

Mucosal Immunol. 2024 Aug 20:S1933-0219(24)00088-6. doi: 10.1016/j.mucimm.2024.08.007. Online ahead of print. ABSTRACT PLX5622 is a small molecular inhibitor of the CSF1 receptor (CSF1R) and is widely used to deplete macrophages within the central nervous system (CNS). We investigated the impact of PLX5622 treatment in wild-type C57BL/6 mice and discovered that one-week treatment with PLX5622 was … Read more

Dysregulated myeloid differentiation in colitis is induced by inflammatory osteoclasts in a TNFα-dependent manner. Maria-Bernadette Madel

by

Mucosal Immunol. 2024 Sep 25:S1933-0219(24)00098-9. doi: 10.1016/j.mucimm.2024.09.005. Online ahead of print. ABSTRACT Inflammatory bowel disease (IBD) is characterized by very severe intestinal inflammation associated with extra-intestinal manifestations. One of the most critical ones is bone destruction, which remains a major cause of morbidity and a risk factor for osteopenia and osteoporosis in IBD patients. In … Read more

APOE4 affects neutrophil-microglia crosstalk in Alzheimer’s disease. Eleonora Terrabuio

by

Trends Immunol. 2024 Sep 24:S1471-4906(24)00210-2. doi: 10.1016/j.it.2024.09.002. Online ahead of print. ABSTRACT Circulating immune cells contribute to the pathogenesis of Alzheimer’s disease (AD), but their role is poorly understood. Rosenzweig et al. recently identified a subset of interleukin (IL)-17+ neutrophils that inhibit neuroprotective microglia in female APOE4 carriers. Blockade of IL-17 signaling or APOE4 deletion … Read more

Disease-associated oligodendroglia: a putative nexus in neurodegeneration. Gonçalo Castelo-Branco

by

Trends Immunol. 2024 Sep 24:S1471-4906(24)00189-3. doi: 10.1016/j.it.2024.08.003. Online ahead of print. ABSTRACT Neural cells in our central nervous system (CNS) have long been thought to be mere targets of neuroinflammatory events in neurodegenerative diseases such as multiple sclerosis (MS) or Alzheimer’s disease. While glial populations such as microglia and astrocytes emerged as active responders and … Read more

Novel human iPSC models of neuroinflammation in neurodegenerative disease and regenerative medicine. Rose Ana Summers

by

Trends Immunol. 2024 Sep 21:S1471-4906(24)00190-X. doi: 10.1016/j.it.2024.08.004. Online ahead of print. ABSTRACT The importance of neuroinflammation in neurodegenerative diseases is becoming increasingly evident, and, in parallel, human induced pluripotent stem cell (hiPSC) models of physiology and pathology are emerging. Here, we review new advancements in the differentiation of hiPSCs into glial, neural, and blood-brain barrier … Read more

Unmasking SARS-CoV-2’s coagulation conspiracy: the role of Spike. Tom Aschman

by

Trends Immunol. 2024 Sep 26:S1471-4906(24)00215-1. doi: 10.1016/j.it.2024.09.007. Online ahead of print. ABSTRACT The recent study by Ryu et al. demonstrates that the SARS-CoV-2 Spike protein binds fibrin(ogen), impacting coagulation and immune responses in mice. In this spotlight article we focus on the described effects on natural killer (NK) cell responses as well as the suggested … Read more

Intracellular C1q – an unexpected player in neuronal proteostasis. Erin E West

by

Trends Immunol. 2024 Sep 25:S1471-4906(24)00214-X. doi: 10.1016/j.it.2024.09.006. Online ahead of print. ABSTRACT Extrahepatic, cell-autonomous, and/or intracellularly active complement components are increasingly recognized as key orchestrators of cell physiological processes. A recent study by Scott-Hewitt et al. demonstrates that microglia-derived C1q unexpectedly associates with the ribosomes of neurons in the aging murine brain, where it impacts … Read more

Sensory nerves unlock the TOLL-7 gate for cancer spread. R K Subbarao Malireddi

by

Trends Immunol. 2024 Sep 25:S1471-4906(24)00213-8. doi: 10.1016/j.it.2024.09.005. Online ahead of print. ABSTRACT Cancers hijack the nervous system for growth and spread. Thus, disrupting neuron-cancer crosstalk holds promise for blocking metastasis. Recently, Padmanaban et al. reported new therapeutic targets and showed that breast cancer cells activate sensory neurons to secrete the neuropeptide substance P (SP), leading … Read more

deneme bonusu veren siteler - canlı bahis siteleri - casino siteleri casino siteleri deneme bonusu veren siteler canlı casino siteleri 301 Moved Permanently

301 Moved Permanently

nginx/1.24.0 (Ubuntu)