inmunoadmin

Precise motif and cross-presentation of coronavirus peptides by feline MHC class I: implications for the mild infection of SARS-CoV-2

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J Immunol. 2025 Jan 1;214(1):115-129. doi: 10.1093/jimmun/vkae006. ABSTRACT As one of the earliest identified susceptible animals for the SARS-CoV-2, cats are also the vulnerable hosts for feline coronaviruses, ie feline enteric coronavirus (FECV). Here, to understand the cross-presentation of coronavirus-derived peptides by cat major histocompatibility complex molecule feline leucocyte antigen (FLA) class I, unpredictable natural … Read more

Suppression of NF-κB and downstream XBP1 by DcR3 contributes to a decrease in antibody secretion

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J Immunol. 2025 Jan 1;214(1):72-84. doi: 10.1093/jimmun/vkae005. ABSTRACT Decoy receptor 3 (DcR3), a soluble receptor in the tumor necrosis factor receptor superfamily, regulates the functions of monocytes, macrophages, dendritic cells, and T cells. Previous studies have demonstrated that DcR3 suppresses B cell proliferation in vitro and ameliorates autoimmune diseases in animal models; however, whether and … Read more

PVR exposure influences the activation, adhesion, and protein expression of human CD8+ T cells, including the CD96-mediated transfer of PVR

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J Immunol. 2025 Jan 1;214(1):55-71. doi: 10.1093/jimmun/vkae002. ABSTRACT Poliovirus receptor (PVR) ligands have gained attention as immunotherapy targets, yet their regulation remains unclear. Here, we examine the impact of PVR exposure on primary human CD8+ T cells. We used flow cytometry and Western blot analysis to quantify expression of PVR and its ligands in naïve … Read more

IL-15 complex enhances agonistic anti-CD40 + anti-PDL1 by correcting the T-bet to Tox ratio in CD8+ T cells infiltrating pancreatic ductal adenocarcinoma

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Cancer Immunol Res. 2025 Mar 12. doi: 10.1158/2326-6066.CIR-24-0758. Online ahead of print. ABSTRACT Agonistic anti-CD40 with anti-PD-1 can elicit objective responses in a small number of patients with pancreatic ductal adenocarcinoma (PDA). Better understanding of their individual effects on the PDA tumor microenvironment will help inform new strategies to further improve outcomes. Herein, we map … Read more

Cytoplasmic WEE1 promotes resistance to PD-1 blockade through hyperactivation of the HSP90A/TCL1/AKT signaling axis in NANOGhigh tumors

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Cancer Immunol Res. 2025 Mar 11. doi: 10.1158/2326-6066.CIR-24-0379. Online ahead of print. ABSTRACT Immune checkpoint blockade (ICB) has revolutionized the therapeutic landscape across various cancer types. However, the emergence of resistance to ICB therapy limits its clinical application. Therefore, it is necessary to better understand immune-resistance mechanisms that could be targeted by actionable drugs, and … Read more

cGAS mRNA-based Immune Agonist Promotes Vaccine Responses and Antitumor Immunity

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Cancer Immunol Res. 2025 Mar 11. doi: 10.1158/2326-6066.CIR-24-0804. Online ahead of print. ABSTRACT mRNA vaccines are recognized as potent tools for immunization against viral diseases and cancer. However, the lack of a vaccine adjuvant limits the efficacy of these treatments. Here, we used cGAS mRNA, which encodes the DNA innate immune sensor, complexed with lipid … Read more

Cytotoxic chemotherapy in a 3D microfluidic device induces dendritic cell recruitment and trogocytosis of cancer cells

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Cancer Immunol Res. 2025 Mar 11. doi: 10.1158/2326-6066.CIR-24-0263. Online ahead of print. ABSTRACT Cytotoxic chemotherapy that kills cancer cells can also elicit anti-tumor immune responses. Therefore, understanding the immunogenic context of cytotoxic chemotherapy can improve combination immunotherapies. In this study, we sought to improve our understanding about dendritic cell (DC) dynamics in cytotoxic chemotherapy-treated tumor … Read more

New thoughts on the gut-immune axis of arthritis. Alexandra Thiran

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Trends Immunol. 2025 Mar 10:S1471-4906(25)00024-9. doi: 10.1016/j.it.2025.01.006. Online ahead of print. ABSTRACT Arthritis is associated with varying degrees of intestinal inflammation and microbiota dysbiosis, leading to the ‘gut-joint axis hypothesis’ in which intestinal and joint inflammation are suggested to be interconnected through immune-microbiota interactions. While clinical observations support this, causality remains uncertain. Rodent models have … Read more

Testosterone and estradiol reduce inflammation of human macrophages induced by anti‐SARS‐CoV‐2 IgG. [[{“value”:”Sona Allahverdiyeva, Chiara E. Geyer, Jennifer Veth, Laura M. de Vries, Steven W. de Taeye, Marit J. van Gils, Jeroen den Dunnen, Hung‐Jen Chen”}]]

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Older and obese individuals are at greater risk of developing severe COVID-19. In this paper, we identified that this may be related to decreased levels of testosterone and estradiol, by showing that these sex hormones reduce the excessive production of proinflammatory cytokines induced by anti-SARS-CoV-2 IgG antibodies. Abstract COVID-19, the disease caused by SARS-CoV-2, particularly … Read more

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