inmunoadmin

Delayed IL-17RA signaling in early life promotes type I interferon/CXCL10-dependent inhibition of pneumococcal clearance. Teniola Idowu

by

Mucosal Immunol. 2026 Aug 10:100399. doi: 10.1016/j.mucimm.2026.100399. Online ahead of print. ABSTRACT Early life is characterized by heightened susceptibility to respiratory pathogens, yet the immune mechanisms that predispose infants to infection remain poorly defined. Using an infant mouse model of Streptococcus pneumoniae (Spn) colonization, we identify an age-dependent delay in IL-17 A production that was … Read more

MAIT cells are associated with eosinophil presence and activation in the inflamed tissue of patients with eosinophilic esophagitis. Jan Devan

by

Mucosal Immunol. 2026 Aug 10:100398. doi: 10.1016/j.mucimm.2026.100398. Online ahead of print. ABSTRACT EoE is an inflammatory condition characterised by tissue lesions and significant activation of immune cells in the oesophageal mucosa. Phenotypic and functional analyses in this study revealed widespread accumulation and activation of multiple immune cell types, with eosinophils showing the most notable expansion … Read more

Skullcapflavone II alleviates osteoarthritis by inhibiting inflammation and ferroptosis via the SLC7A11/GPX4 signaling pathway

by

J Immunol. 2026 Aug 4;215(8):vkag230. doi: 10.1093/jimmun/vkag230. ABSTRACT Osteoarthritis (OA), the most prevalent degenerative joint disease, leads to significant disability in the elderly and is characterized by functional and structural deterioration of the knee joint. This study aimed to investigate the therapeutic potential of skullcapflavone II (SkII), a flavonoid known for its anti-inflammatory properties, in … Read more

Metabolic crosstalk between c-Myc and glutamine utilization sustains IgM+ B-cell immunity in teleosts

by

J Immunol. 2026 Aug 4;215(8):vkag227. doi: 10.1093/jimmun/vkag227. ABSTRACT B-cell responses rely on a tightly coordinated interplay between transcriptional programs and metabolic reprogramming. Upon activation, B cells remodel their metabolic profiles, with enhanced glutamine metabolism supporting biomass synthesis and proliferation. However, whether and how glutaminolysis underpins B-cell responses in early vertebrates remains largely unexplored. Here, using … Read more

The CXCL10/CXCR3 axis drives actin remodeling to recruit CD4+ T cells to gut epithelium during transmissible gastroenteritis virus infection

by

J Immunol. 2026 Aug 4;215(8):vkag222. doi: 10.1093/jimmun/vkag222. ABSTRACT The immune system initially protects hosts against viral pathogens, with chemokines guiding immune cell movement. However, their expression patterns and immune cell recruitment mechanisms during transmissible gastroenteritis virus (TGEV) infection are still not fully understood. Here, we identified a distinct chemokine expression profile in intestinal epithelial cells … Read more

The IL-1 system in inflammation and cancer. Cecilia Garlanda

by

Semin Immunol. 2026 Aug 8;83:102051. doi: 10.1016/j.smim.2026.102051. Online ahead of print. ABSTRACT Inflammation is a pathogenetic driver of several pathological conditions, including cancer. The tumor microenvironment, which includes cellular, molecular, and structural components, is an essential component of cancer, involved in tumor promoting or controlling processes. In particular, inflammatory players contribute to the establishment of … Read more

IgA binding characteristics of golden hamster and ferret Fcα receptors

by

J Immunol. 2026 Aug 4;215(8):vkag218. doi: 10.1093/jimmun/vkag218. ABSTRACT Golden hamster (Mesocricetus auratus) and ferret (Mustela putorius furo) are important animal models in studies of human infectious disease. They are used widely to investigate pathogen-spreading mechanisms and host immunology to evaluate the safety and efficacy of small molecules, biologic drugs and vaccines. To this end, immunoglobulin … Read more

Delivery of extracellular vesicle-associated microRNA-146a regulates human monocyte phenotype and function

by

J Immunol. 2026 Aug 4;215(8):vkag226. doi: 10.1093/jimmun/vkag226. ABSTRACT CCR2+ monocytes are recruited to sites of acute myocardial injury, where they play a critical role in clearing necrotic debris and replenishing the depleted resident macrophage population. Although this response is necessary for early tissue repair, prolonged activation of inflammatory pathways and persistent recruitment of CCR2+ monocytes … Read more

Identifying molecular signatures underpinning treatment responses to novel therapeutics influencing COVID-19 outcomes

by

J Immunol. 2026 Aug 4;215(8):vkag189. doi: 10.1093/jimmun/vkag189. ABSTRACT COVID-19 continues to present ongoing global health challenges driven by diverse immune responses and heterogeneous clinical outcomes. The ACCORD trial evaluated 3 investigational treatments-bemcentinib, tozorakimab, and zilucoplan-in patients hospitalized with COVID-19, each of which has demonstrated clinical efficacy. To better understand their molecular mechanisms, we conducted a … Read more

Sorting nexin 5 deficiency impairs MHC class II antigen presentation and inflammatory responses during tuberculosis

by

J Immunol. 2026 Aug 4;215(8):vkag217. doi: 10.1093/jimmun/vkag217. ABSTRACT Tuberculosis (TB) remains one of the leading causes of death from a single infectious agent worldwide, yet the host pathways that regulate antigen presentation and lung inflammation during Mycobacterium tuberculosis (Mtb) infection are incompletely defined. Sorting nexin 5 (SNX5) is a protein implicated in endosomal trafficking, antigen … Read more

deneme bonusu veren siteler - canlı bahis siteleri - casino siteleri casino siteleri deneme bonusu veren siteler canlı casino siteleri cURL Hatası: Could not resolve host: lkl.dolarkurum.com