inmunoadmin

Innate immune reprogramming of chicken macrophages by sodium butyrate enhances reactive oxygen species-mediated antimicrobial responses in vitro

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J Immunol. 2026 Aug 4;215(8):vkag209. doi: 10.1093/jimmun/vkag209. ABSTRACT In the established model of classical trained immunity, metabolic and epigenetic hubs serve as central integrators of innate memory. While typically associated with proinflammatory reprogramming, the regulation of autophagy and cellular proteostasis remains essential for guiding macrophage differentiation and ensuring efficient pathogen clearance without excessive inflammation. In … Read more

TRECing down the source: naive and memory T cell generation in dirty mice and men

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J Immunol. 2026 Aug 4;215(8):vkag216. doi: 10.1093/jimmun/vkag216. ABSTRACT Healthy aging relies on the maintenance of a diverse T cell pool. This diversity is ensured by balancing thymic output, differentiation of naive into memory T cells, T cell proliferation and cell death. For naive T cells, the balance of these processes differs between standard laboratory mice … Read more

Mouse NK cell functional maturation is dependent on MHC I​Capucine Bourel on 11 de August de 2026 at 10:00

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J Leukoc Biol. 2026 Aug 11:qiag114. doi: 10.1093/jleuko/qiag114. Online ahead of print. ABSTRACT NK cells effectively eliminate infected cells or tumour cells. The acquisition of cytotoxic functions occurs throughout NK cell functional maturation, a process that is commonly defined by the sequential expression of CD27 and CD11b. In addition, NK cell cytotoxicity is finely tuned … Read more

Kmt2c and Kmt2d histone methyltransferase deficiencies compromise macrophage function​Burcu Al on 11 de August de 2026 at 10:00

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J Leukoc Biol. 2026 Aug 11:qiag110. doi: 10.1093/jleuko/qiag110. Online ahead of print. ABSTRACT Methylation of histone (H) 3 lysine (K) 4 has a well-established role in innate immune responses, but the contribution of H3K4 methyltransferases Kmt2c and Kmt2d in innate immunity is incompletely understood. Using conditional knockout (KO) mouse models, we investigated how Kmt2c- and … Read more

H2AFY2 suppresses exhaustion and enhances antitumor activity of CAR-T cells through transcriptional and epigenetic modifications

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Cancer Immunol Res. 2026 Aug 11. doi: 10.1158/2326-6066.CIR-25-1334. Online ahead of print. ABSTRACT Chimeric antigen receptor (CAR)-T cell exhaustion constitutes a critical barrier to sustained antitumor efficacy. Through transcriptomic analysis of CAR-T cells from patients with lymphoma, we identified the histone variant macroH2A2 (H2AFY2) as a critical regulator of T cell exhaustion-a finding consistently observed … Read more

The pre-treatment tumor microenvironment immune status determines Bacillus Calmette-Guerin immunotherapy response in early-stage bladder cancer

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Cancer Immunol Res. 2026 Aug 11. doi: 10.1158/2326-6066.CIR-25-1445. Online ahead of print. ABSTRACT Bacillus Calmette-Guérin (BCG) is the standard adjuvant therapy for early-stage bladder cancer (BCa), based on its immunostimulatory activity. However, over half of patients experience BCG failure and subsequent recurrence. The heterogeneity of the tumor microenvironment may influence BCG response, however this relationship … Read more

Cover Story: Eur. J. Immunol. 8’26.

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Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

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