inmunoadmin

Enforcing mTORC1 activity in therapeutic CD4+ T cells promotes persistence but eventual immune exhaustion

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J Immunol. 2026 Aug 4;215(8):vkag206. doi: 10.1093/jimmun/vkag206. ABSTRACT There is substantial interest in developing novel engineering strategies to promote the sustained metabolic fitness of therapeutic T cells. We previously showed that overexpression of RAS homologue enriched in brain (RHEB), a positive regulator of mammalian target of rapamycin complex 1 (mTORC1), promotes aerobic glycolysis and increases … Read more

IL-1-driven systemic inflammation in tumour progression and metastatic spread. Jacqueline Alford

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Semin Immunol. 2026 Aug 7;83:102052. doi: 10.1016/j.smim.2026.102052. Online ahead of print. ABSTRACT Inflammation is a fundamental immune response that protects against injury and infection; however, when unresolved, it can contribute to disease pathogenesis. Chronic inflammation is a hallmark of cancer that promotes tumour initiation and metastatic spread. Notably, this relationship is bidirectional: while chronic inflammation … Read more

Obesity hampers bacteria killing by human neutrophils​Nathalia Naranjo-Pinto on 7 de August de 2026 at 10:00

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J Leukoc Biol. 2026 Aug 7:qiag111. doi: 10.1093/jleuko/qiag111. Online ahead of print. ABSTRACT Obesity is a disease associated with an increased risk of various medical complications, including cardiovascular problems, diabetes, and infectious diseases. The higher incidence of infections in individuals with obesity is likely due to impaired immune functions. Neutrophils deploy microbicidal functions. However, it … Read more

Neutrophils induce effective antibody responses to the pneumococcal conjugate vaccine by inhibiting regulatory T cells​Essi Y I Tchalla on 7 de August de 2026 at 10:00

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J Leukoc Biol. 2026 Aug 7:qiag112. doi: 10.1093/jleuko/qiag112. Online ahead of print. ABSTRACT Neutrophils are required for production of protective antibodies in response to the pneumococcal conjugate vaccine (PCV), however, the mechanisms behind that are not known. Here, using a mouse model, we found that depletion of neutrophils at the time of vaccination in female … Read more

Antigen presentation at the blood-brain barrier amplifies neuroinflammation. Sidar Aydin

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Trends Immunol. 2026 Aug 7:S1471-4906(26)00185-7. doi: 10.1016/j.it.2026.07.006. Online ahead of print. ABSTRACT Immune surveillance of the central nervous system (CNS) is regulated by the brain barriers. Antigen presentation at the blood-brain barrier (BBB) has been proposed to promote antigen-specific T-cell entry into the CNS, largely based on in vitro studies. Recent in vivo and transcriptomic … Read more

Identification of a regulatory allosteric site in Arid5a unveils a therapeutic axis for systemic inflammation

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J Immunol. 2026 Aug 4;215(8):vkag215. doi: 10.1093/jimmun/vkag215. ABSTRACT Adenine-thymine (AT)-rich interactive domain-containing protein 5a (Arid5a) is an RNA-binding protein (RBP) that post-transcriptionally stabilizes mRNAs encoding proinflammatory mediators, including Interleukin-6 (IL-6), thereby amplifying inflammation. However, structural basis and regulatory mechanisms of Arid5a function remain poorly defined. In this study, we identified and characterized a conserved allosteric … Read more

Fluid shear stress as a co-stimulatory cue to enhance T cell priming and restore activation in cancer patient T cells

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J Immunol. 2026 Aug 4;215(8):vkag166. doi: 10.1093/jimmun/vkag166. ABSTRACT Cancer patient-derived T cells often exhibit impaired activation and functional responsiveness due to chronic antigen exposure and therapy-induced immune dysregulation, limiting the efficacy of current immunotherapies. Mechanical forces, such as fluid shear stress (FSS), are emerging as critical regulators of immune cell activation, yet their role in … Read more

Complement System in Bone Inflammation and Autoimmunity​Adrita Guha on 6 de August de 2026 at 10:00

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J Leukoc Biol. 2026 Aug 6:qiag109. doi: 10.1093/jleuko/qiag109. Online ahead of print. ABSTRACT The complement system constitutes a fundamental element of the innate immune response, playing a pivotal role in the identification and eradication of pathogens. The orchestration of complement component activation is closely linked to bone remodeling and the maintenance of skeletal homeostasis. C3a … Read more

Emergency granulopoiesis and innate immune memory in inflammatory bowel disease. Sílvia Pires

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Trends Immunol. 2026 Aug 5:S1471-4906(26)00183-3. doi: 10.1016/j.it.2026.07.004. Online ahead of print. ABSTRACT Emerging evidence now points to innate tissue immunity as a critical orchestrator of both local tissue adaptation and long-range hematopoietic reprogramming, including the amplification of emergency granulopoiesis through bone marrow progenitor remodeling. These findings position the intestine as an instructive niche capable of … Read more

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