inmunoadmin

J Immunol. 2026 Aug 4;215(8):vkaf313. doi: 10.1093/jimmun/vkaf313. ABSTRACT COVID-19 is a disease triggered by SARS-CoV-2 and some individuals develop a severe form that can progress to multiple organ failure. Neutrophils have been described as responsible for the release of neutrophil extracellular traps (NETs). The role of the elastase and myeloperoxidase (MPO) in NET release by … Read more

J Immunol. 2026 Aug 4;215(8):vkag225. doi: 10.1093/jimmun/vkag225. ABSTRACT Idiopathic inflammatory myopathy (IIM) is a systemic autoimmune disease targeting muscle and extramuscular organs, but the molecular mechanisms driving IIM pathogenesis remain largely undefined. Muscle fibroblasts are central to orchestrating inflammation in myositis. Here, we investigated muscle fibroblast dynamics using a single-cell RNA sequencing approach in an … Read more

J Immunol. 2026 Aug 4;215(8):vkag210. doi: 10.1093/jimmun/vkag210. ABSTRACT Class I MHC peptide (MHC-Ip) multimers are well-established reagents that detect antigen-specific T cells. The classical method for production of MHC-Ip multimers begins with the expression of MHC heavy chains (HCs) and β2-microglobulin (β2m) subunits as inclusion bodies in Escherichia coli and is followed by denaturant solubilization, … Read more

J Immunol. 2026 Aug 4;215(8):vkag208. doi: 10.1093/jimmun/vkag208. ABSTRACT People with HIV (PWH) exhibit persistent immune activation despite effective antiretroviral therapy, contributing to risk of non-AIDS-associated comorbidities such as cancer. Cell populations reflecting immune remodeling trajectories preceding malignancy are poorly characterized. Using peripheral blood mononuclear cells from an adult cohort (25-65 yr), we quantified the tetraspanin … Read more