inmunoadmin

Enteric α-defensins contribute to intestinal mucosal immunity against SARS-CoV-2 infection. Yilin Yang

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Mucosal Immunol. 2026 Aug 1:100392. doi: 10.1016/j.mucimm.2026.100392. Online ahead of print. ABSTRACT SARS-CoV-2 primarily targets epithelial cells in the respiratory and intestinal tracts where its cognate receptor ACE2 and obligate processing enzymes furin and TMPRSS2 are richly expressed. However, compared with severe inflammation and tissue damage in the lungs of a COVID-19 patient, clinical lesions … Read more

Recurrent pericarditis in children: evidence, controversies, and emerging perspectives

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Curr Opin Immunol. 2026 Jul 31;102:102833. doi: 10.1016/j.coi.2026.102833. Online ahead of print. ABSTRACT Recurrent pericarditis complicates approximately one-third of initial pericarditis episodes in children. Once considered a postinfectious sequel, it is now understood as an autoinflammatory disorder sustained by dysregulated interleukin-1 signaling and inflammasome hyperactivation. This review evaluates therapeutic strategies for idiopathic recurrent pericarditis in … Read more

SenSpots: when B cells age in place. Qianzhao Ji

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Trends Immunol. 2026 Aug 1:S1471-4906(26)00187-0. doi: 10.1016/j.it.2026.07.008. Online ahead of print. ABSTRACT Spatial multi-omics of aging human lymph nodes by Fan and colleagues reveals that immunosenescence manifests as focal B cell coalescence into ‘SenSpots’ within germinal centers, where concerted epigenetic, transcriptional, proteomic, and metabolic reprogramming spatially orchestrates the decline of humoral immunity. PMID:42538165 | DOI:10.1016/j.it.2026.07.008

Targeting the fate of exhausted CD8+ T cells. Daniel T Utzschneider

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Trends Immunol. 2026 Jul 31:S1471-4906(26)00181-X. doi: 10.1016/j.it.2026.07.002. Online ahead of print. ABSTRACT CD8+ T cell exhaustion is increasingly recognized as a regulated adaptation to chronic antigenic stimulation rather than a simple immune failure. Indeed, recent studies reveal that exhaustion is imprinted early after T cell activation, integrating transcriptional and epigenetic cues to balance effector function … Read more

IL-22 synergizes with IL-17 to promote mucosal inflammation and bone loss

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J Immunol. 2026 Jul 10;215(7):vkag186. doi: 10.1093/jimmun/vkag186. ABSTRACT Interleukin (IL)-22 mediates immune cell communication with nonhematopoietic cells and was shown to exert protective or destructive effects in different disease contexts. In the oral mucosal disease periodontitis, IL-22 has been associated with increased tissue destruction, although cause-and-effect evidence and the underlying mechanisms are lacking. Here, we … Read more

FcγRIII blockade prevents anti-HLA-mediated platelet clearance in a humanized murine model of platelet transfusion refractoriness

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J Immunol. 2026 Jul 10;215(7):vkag195. doi: 10.1093/jimmun/vkag195. ABSTRACT Immune platelet transfusion refractoriness (iPTR) is a major complication in transfusion medicine. Although anti-HLA antibodies are recognized contributors, the mechanisms by which they drive platelet clearance remain incompletely defined. We examined sera from 18 patients with iPTR and found that anti-HLA antibodies induced uptake of human platelets … Read more

Premature birth and Cesarean section are associated with significant differences in neonatal CD4+ T cell gene expression and function​Carlos Jesús Ventura-Martínez on 31 de July de 2026 at 10:00

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J Leukoc Biol. 2026 Jul 31:qiag105. doi: 10.1093/jleuko/qiag105. Online ahead of print. ABSTRACT Premature birth and cesarean section are associated with increased morbidity and inflammatory diseases. However, their impact on neonatal immunity remains incompletely defined. To explore how gestational age and mode of delivery contribute to early immune programming, we analyzed CD4+ T cells, central … Read more

Immune hallmarks of recurrent immune checkpoint inhibitor-mediated inflammatory arthritis

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Cancer Immunol Res. 2026 Jul 31. doi: 10.1158/2326-6066.CIR-25-1639. Online ahead of print. ABSTRACT Immune checkpoint inhibitor (ICI) therapy is often associated with immune-related adverse events including inflammatory arthritis (ICI-IA). However, the mechanisms underlying ICI-IA, especially its recurrence, are not well understood. In this study, we sought to elucidate mechanisms of recurrent ICI-IA by analyzing longitudinal … Read more

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