inmunoadmin J Immunol. 2025 Apr 9:vkaf034. doi: 10.1093/jimmun/vkaf034. Online ahead of print. ABSTRACT Imbalanced effector and regulatory CD4+ T cell subsets drive many inflammatory diseases. These T cell subsets rely on distinct metabolic programs, modulation of which differentially affects T cell fate and function. Lipid metabolism is fundamental yet remains poorly understood across CD4+ T cell … Read more
J Immunol. 2025 Apr 9:vkaf037. doi: 10.1093/jimmun/vkaf037. Online ahead of print. ABSTRACT Cytokine-induced killer (CIK) cells, as an adoptive immunotherapy, are effective at treating colorectal cancer (CRC). However, whether an individual can benefit from CIK cell therapy remains unclear. In this study, we analyzed the long-term effects of CIK cell therapy and specifically the relationship … Read more
Semin Immunol. 2025 Apr 8;78:101949. doi: 10.1016/j.smim.2025.101949. Online ahead of print. ABSTRACT Glucocorticoids (GCs) are steroid hormones with diverse and important roles in the physiologic response to stress. These include permissive and suppressive effects on immunity, which help prepare the organism for future infectious stressors and control the immunological response to a recent stressor, preventing … Read more
J Leukoc Biol. 2025 Apr 9:qiaf041. doi: 10.1093/jleuko/qiaf041. Online ahead of print. NO ABSTRACT PMID:40203078 | DOI:10.1093/jleuko/qiaf041
J Immunol. 2025 Apr 8:vkaf030. doi: 10.1093/jimmun/vkaf030. Online ahead of print. ABSTRACT Studies support a role for natural killer (NK) cells in cancer control, making these cells attractive for immunotherapy. One method being tested to make effective NK cells is the ex vivo activation with interleukin (IL)-12, IL-15, and IL-18. We demonstrate that this induces … Read more
Curr Opin Immunol. 2025 Apr 3;94:102554. doi: 10.1016/j.coi.2025.102554. Online ahead of print. ABSTRACT Autoimmune diseases arise when self-antigen-specific T and B cells escape central and peripheral mechanisms of tolerance. One such mechanism is control of autoreactivity by regulatory T cells (Tregs), which have an essential role in suppressing autoimmunity. Consequently, there is significant interest in … Read more
J Leukoc Biol. 2025 Apr 5:qiaf039. doi: 10.1093/jleuko/qiaf039. Online ahead of print. ABSTRACT Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation. The ferroptosis mechanism involves complex interactions between fatty acid metabolism, iron metabolism, lipid peroxidation, and antioxidative defense mechanisms. Fatty acids, especially polyunsaturated fatty acids (PUFAs), are susceptible to … Read more
J Immunol. 2025 Apr 4:vkaf010. doi: 10.1093/jimmun/vkaf010. Online ahead of print. ABSTRACT Neutrophils are the first line of defense against pathogens, combating them by using several antimicrobial mechanisms. These cells display a remarkable plasticity that can be molded by the different environments that neutrophils confront to protect the host, therefore presenting diverse phenotypes. Actually, pro- … Read more
J Immunol. 2025 Apr 4:vkaf035. doi: 10.1093/jimmun/vkaf035. Online ahead of print. ABSTRACT Tissue-resident memory cells contribute to allergen-induced inflammation and airway hyperresponsiveness, but relatively little is known of the cellular and molecular mechanisms underlying the accumulation of these cells in the lung. Here, we show that allergen-specific CD4+ resident memory T cells are virtually absent … Read more
J Immunol. 2025 Apr 4:vkaf048. doi: 10.1093/jimmun/vkaf048. Online ahead of print. ABSTRACT T-cell central tolerance is controlled by thymocyte TCR recognition of self-peptides presented by thymic APCs. While thymic epithelial cells are essential for T-cell central tolerance, a variety of other traditional APCs also play critical roles in T-cell selection. Similar to how peripheral APCs … Read more
