inmunoadmin

First-in-Human Clinical Trial of Vaccination with WDVAX, a Dendritic Cell Activating Scaffold Incorporating Autologous Tumor Cell Lysate, in Metastatic Melanoma Patients

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Cancer Immunol Res. 2025 Apr 11. doi: 10.1158/2326-6066.CIR-24-0333. Online ahead of print. ABSTRACT The optimal means to prime for effective anti-tumor immunity in a cancer patient remains elusive in the current era of checkpoint blockade. Crafting a strategy to amplify CD8+ T cells while blocking regulatory cells should increase immunotherapy efficacy. Biomaterial carriers have been … Read more

Mitochondrial fusion reduces T cell susceptibility to HIV infection through citrate modulation​Zichen Song on 11 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 11:qiaf042. doi: 10.1093/jleuko/qiaf042. Online ahead of print. ABSTRACT Inhibiting the metabolic activity of CD4+ T cells can effectively reduce HIV infection. Mitochondria, as critical organelles in eukaryotic metabolism, play a significant role in the progression of many diseases. The change of mitochondrial dynamics is an important process of mitochondrial regulation … Read more

Rheumatoid arthritis – the role of T cells in this complex systemic autoimmune disease

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Curr Opin Immunol. 2025 Apr 9;94:102555. doi: 10.1016/j.coi.2025.102555. Online ahead of print. ABSTRACT Rheumatoid arthritis (RA) is a chronic inflammatory disease of the joints that can affect individuals at any age of life. While involvement of the immune system in RA has long been clear, current treatments remain limited to interventions that broadly suppress immune … Read more

The stress and the alarmin-like cytokine interleukin-37 mediated extracellular and intracellular signal pathways. Yan Li

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Semin Immunol. 2025 Apr 9;78:101952. doi: 10.1016/j.smim.2025.101952. Online ahead of print. ABSTRACT IL-37, as a member of the IL-1 cytokine family, has been extensively characterized as a critical immunoregulatory molecule that suppresses both innate and adaptive immune responses. This cytokine demonstrates constitutive and inducible expression patterns across various immune and non-immune cells in response to … Read more

Interplay between the complement system and other immune pathways in the tumor microenvironment. Cecilia Garlanda

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Semin Immunol. 2025 Apr 9;78:101951. doi: 10.1016/j.smim.2025.101951. Online ahead of print. ABSTRACT Tumor growth and spread are sustained by the tumor microenvironment. Inflammatory cells and pathways have a fundamental role in the tumor microenvironment, driving or conditioning the functional activation of other leukocyte subsets and favoring evasion of anti-tumor immunity. One of the inflammatory pathways … Read more

The road ahead for chimeric antigen receptor T cells

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J Immunol. 2025 Apr 10:vkaf047. doi: 10.1093/jimmun/vkaf047. Online ahead of print. ABSTRACT Chimeric antigen receptor T (CART) cell therapy is an innovative form of immunotherapy that has shown remarkable and long-term responses in patients with B-cell malignancies. Over the years, the field has made significant progress in our understanding of the successes and challenges associated … Read more

A frameshift-generated cancer neoepitope that controls tumor burden in prophylaxis as well as therapy

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J Immunol. 2025 Apr 10:vkaf016. doi: 10.1093/jimmun/vkaf016. Online ahead of print. ABSTRACT Insertion or deletion of one or two base pairs within a coding region causes a frameshift, which has the potential to generate neoepitopes (InDel-generated neoepitopes) that lack a self-counterpart and are entirely novel. Despite the obvious appeal of InDel-generated neoepitopes, and the demonstration … Read more

IRF4-regulated transcriptional and functional heterogeneity of lung-resident CD11b+ cDC2 subsets during influenza virus infection

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J Immunol. 2025 Apr 10:vkaf060. doi: 10.1093/jimmun/vkaf060. Online ahead of print. ABSTRACT Lung-resident conventional dendritic cells (cDCs) coordinate immune responses to respiratory viruses in the respiratory tract or after migration to mediastinal lymph nodes (mLN). Migratory DCs include cDC1s (CD103+XCR1+CD24hi) expressing IRF8 or cDC2s (CD11b+SIRPα+CD24+) expressing IRF4. IRF4+ cDC2s are divided into a CD24hi subset … Read more

The TRIB2-DNMT1 pathway generates an immune cold microenvironment in glioblastoma and its inhibition promotes immunotherapy

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Cancer Immunol Res. 2025 Apr 10. doi: 10.1158/2326-6066.CIR-24-0807. Online ahead of print. ABSTRACT The lack of response of glioblastoma (GBM) to immunotherapy is closely related to the limited number of T cells in the tumor microenvironment (TME). However, it is still not known why GBM is characterized by an immune-cold TME with reduced CD8+ T-cell … Read more

Mitochondrial fatty acid synthesis and MECR regulate CD4+ T cell function and oxidative metabolism

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J Immunol. 2025 Apr 9:vkaf034. doi: 10.1093/jimmun/vkaf034. Online ahead of print. ABSTRACT Imbalanced effector and regulatory CD4+ T cell subsets drive many inflammatory diseases. These T cell subsets rely on distinct metabolic programs, modulation of which differentially affects T cell fate and function. Lipid metabolism is fundamental yet remains poorly understood across CD4+ T cell … Read more

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