inmunoadmin

CD3xHER2 bsAb‐Mediated Activation of Resting T‐cells at HER2 Positive Tumor Clusters Is Sufficient to Trigger Bystander Eradication of Distant HER2 Negative Clusters Through IFNγ and TNFα. [[{“value”:”Chen‐Yi Liao, Patrick Engelberts, Michiel van Dijk, Annemieke Timmermans, John W. M. Martens, Elsa Neubert, Erik H.J. Danen”}]]

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Spatiotemporal aspects of bystander killing triggered by bispecific antibodies: (1) Resting T-cells recognize HER2+ tumors via CD3xHER2 bsAbs. (2) Local T-cell activation induces direct HER2+ tumor killing and IFNγ/TNFα release. (3) IFNγ/TNFα mediate paracrine killing of HER2− cells. (4) HER2− cells are eliminated in mixed (A) and distant (B) areas. ABSTRACT Bispecific antibodies (bsAbs) bridging … Read more

CST Is Epistatic With Shieldin to Limit DNA Double‐Strand Break End Resection and Promote Repair During Igh Class Switch Recombination. [[{“value”:”Chloé Lescale, Timea Marton, Amaury Vaysse, Guillaume Rode, Estelle Vincendeau, Alice Libri, François Dossin, Ludovic Deriano”}]]

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Here we show that CST and SHLD are required for CSR, while SHLD1-CTC1 interaction via the SHLD1 LDLP motif is dispensable. Mechanistically, we show that CTC1 and SHLD1 are epistatic during CSR, preventing genetic instability, exacerbated DSB end-resection, and microhomology-mediated end-joining at Igh switching sites. Created in Biorender.com. ABSTRACT Downstream of 53BP1-RIF1 lies the Shieldin … Read more

The intestinal microbiome in type 1 diabetes: bridging early childhood exposures with translational advances

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Curr Opin Immunol. 2025 Apr 1;94:102553. doi: 10.1016/j.coi.2025.102553. Online ahead of print. ABSTRACT Type 1 diabetes (T1D) results from T cell-mediated destruction of pancreatic β-cells, requiring lifelong insulin therapy and glycemic monitoring. While genetic risk, particularly HLA class II, is well established, rising T1D incidence and earlier onset suggest environmental modifiers. Mouse models show that … Read more

The metabolic drivers of IFN-γ release: glycolysis and acetyl CoA ride in the front seat

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J Immunol. 2025 Apr 3:vkaf045. doi: 10.1093/jimmun/vkaf045. Online ahead of print. ABSTRACT Interferon gamma (IFN-γ) is a pleotropic cytokine which is a central mediator of the immune response to pathogen infection, while also playing important roles in tumour suppression and the pathogenesis of various autoimmune diseases. Consequently, there is potential utility in the treatment of … Read more

The immunopathogenesis of SARS-CoV-2 infection: Overview of lessons learned in the first 5 years

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J Immunol. 2025 Apr 3:vkaf033. doi: 10.1093/jimmun/vkaf033. Online ahead of print. ABSTRACT This review provides a broad overview of lessons learned in the five years since COVID-19 was identified. It is a bimodal disease, starting with an initially virus-driven phase, followed by resolution or ensuing inappropriate immune activation causing severe inflammation that is no longer … Read more

Cutting Edge: Cooperative interferon regulatory factor network shapes the NK-cell antiviral response

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J Immunol. 2025 Apr 3:vkaf041. doi: 10.1093/jimmun/vkaf041. Online ahead of print. ABSTRACT Natural killer (NK) cells are innate lymphocytes that exhibit adaptive traits particularly evident during cytomegalovirus (CMV) infection. Following mouse CMV (MCMV) infection, NK cells upregulate the transcription factors IRF4 and IRF8, which are indispensable for their survival and proliferation upon viral infection. However, … Read more

Characterization of autoantibody profiles in clusters of systemic lupus erythematosus using a novel autoantigen discovery technology

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J Immunol. 2025 Apr 3:vkae025. doi: 10.1093/jimmun/vkae025. Online ahead of print. ABSTRACT Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease characterized by a wide range of clinical and immunologic manifestations, most prominently, the production of autoantibodies to nuclear components (ANAs). A previous study delineated four SLE patient clusters based on autoantibody expression to … Read more

Hypertonic intranasal vaccines gain nasal epithelia access to exert strong immunogenicity. Soichiro Hashimoto

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Mucosal Immunol. 2025 Apr 1:S1933-0219(25)00032-7. doi: 10.1016/j.mucimm.2025.03.006. Online ahead of print. ABSTRACT Intranasal vaccines potentially offer superior protection against viral infections compared with injectable vaccines. The immunogenicity of intranasal vaccines including adenovirus vector (AdV), has room for improvement, while few options are available for safe execution. In this study, we demonstrate that modifying a basic … Read more

The role of the adaptive immune system in the initiation and persistence of multiple sclerosis. Ali Maisam Afzali

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Semin Immunol. 2025 Apr 2;78:101947. doi: 10.1016/j.smim.2025.101947. Online ahead of print. ABSTRACT Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system (CNS) in which complex networks of interacting immune cells initiate and sustain the disease. The pathogenesis of relapsing MS is driven by adaptive immune cells that become activated outside the … Read more

Complement and the hallmarks of cancer. Mikel Rezola Artero

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Semin Immunol. 2025 Apr 2;78:101950. doi: 10.1016/j.smim.2025.101950. Online ahead of print. ABSTRACT The hallmarks of cancer are a set of traits that normal cells acquire during their transformation into malignancy. Among the biological processes influencing these hallmarks, the innate immune complement system plays a critical role. It can operate canonically-in blood and tissues-via phagocytosis, inflammation, … Read more

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