inmunoadmin

BCG induced innate immune response heterogeneity and susceptibility to pediatric tuberculosis

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J Immunol. 2025 Apr 2:vkae062. doi: 10.1093/jimmun/vkae062. Online ahead of print. ABSTRACT Although immune responses to bacillus Calmette-Guerin (BCG)-vaccination and susceptibility to pediatric tuberculosis (TB) vary across individuals, the underlying cellular mechanism regulating this heterogeneity is poorly understood. We used a nested case-control study with a 2-yr prospective observation period to examine whether genetic variation … Read more

Lung NK cells are sufficient to control viral dissemination during respiratory MCMV infection

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J Immunol. 2025 Apr 2:vkaf039. doi: 10.1093/jimmun/vkaf039. Online ahead of print. ABSTRACT Murine cytomegalovirus (MCMV) respiratory dissemination schemes, which mimic natural infection routes, have only recently become an area of investigation. Using an intratracheal (i.t.) infection method, we discovered that the respiratory infection route yields differential infection kinetics compared to the widely used intraperitoneal (i.p.) … Read more

Neutrophil KLF2 regulates inflammasome-dependent neonatal mortality from endotoxemia​Devashis Mukherjee on 2 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 2:qiaf040. doi: 10.1093/jleuko/qiaf040. Online ahead of print. ABSTRACT Preterm neonates die at a significantly higher rate from sepsis than full-term neonates, attributable to their dysregulated immune response. In addition to tissue destruction caused directly by bacterial invasion, an overwhelming cytokine response by the immune cells to bacterial antigens also results … Read more

WDFY1-expressing follicular dendritic cells play a critical role in lupus development in cGVHD mouse model

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J Immunol. 2025 Apr 1:vkaf017. doi: 10.1093/jimmun/vkaf017. Online ahead of print. ABSTRACT Follicular dendritic cells (FDCs) retain Ag-containing immune complexes (ICs), facilitate the selection of high-affinity antibodies, and protect B cells in germinal centers (GCs) from apoptosis. In systemic lupus erythematosus patients, apoptotic debris is found on the surface of FDCs. However, the mechanisms by … Read more

IL-1β+ macrophages and the control of pathogenic inflammation in cancer. Nicoletta Caronni

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Trends Immunol. 2025 Mar 31:S1471-4906(25)00059-6. doi: 10.1016/j.it.2025.03.001. Online ahead of print. ABSTRACT While highlighting the complexity and heterogeneity of tumor immune microenvironments, the application of single-cell analyses in human cancers has identified recurrent subsets of tumor-associated macrophages (TAMs). Among these, interleukin (IL)-1β+ TAMs – cells with high levels of expression of inflammatory response and tissue … Read more

Memory-like natural killer cell and CD19-antibody based immunotherapy in combination with tyrosine-kinase inhibition has antitumor effects against Ph(-like) acute lymphoblastic leukemia

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Cancer Immunol Res. 2025 Apr 1. doi: 10.1158/2326-6066.CIR-24-0746. Online ahead of print. ABSTRACT Philadelphia-like acute lymphoblastic leukemia (Ph-like ALL) is a molecularly distinct tyrosine kinase-driven cancer that has a high relapse rate and poor response toward combinatorial chemotherapy. Tyrosine kinase inhibitors (TKI) in the clinic improve the survival of patients with Ph-like ALL. Engineered antibody … Read more

In situ delivery of Gasdermin E mRNA promotes antitumor immunity via creatine-elicited type Ⅰ interferon signaling in monocytes

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Cancer Immunol Res. 2025 Apr 1. doi: 10.1158/2326-6066.CIR-24-0834. Online ahead of print. ABSTRACT Local immunotherapy stimulates immune responses against tumors while avoiding adverse effects associated with systemic administration. However, current strategies for tumor-targeted in situ immunotherapy are still limited. mRNA-based gene therapy represents a promising strategy. Gasdermin E (GSDME)-mediated pyroptosis is reported to exert anti-tumor … Read more

Naturally arising memory-phenotype CD4+ T lymphocytes give rise to multiple helper subsets to contribute to tumor immunity while inhibiting GVHD

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Cancer Immunol Res. 2025 Apr 1. doi: 10.1158/2326-6066.CIR-24-0598. Online ahead of print. ABSTRACT Memory-phenotype (MP) CD4+ T lymphocytes spontaneously develop in steady state from peripheral naïve precursors in a manner dependent on self-antigen recognition. While MP cells possess innate type 1 and 3 effector functions that can contribute to host defense and autoimmunity, their immunological … Read more

Accurate enumeration of pathogen-specific and virtual memory CD8 T cells after infection

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J Immunol. 2025 Apr 1:vkaf007. doi: 10.1093/jimmun/vkaf007. Online ahead of print. ABSTRACT Establishing the magnitude and kinetics of polyclonal Ag-specific CD8 T-cell responses, in addition to their functional fitness, is critical for evaluating a host’s ability to respond to different kinds of infections and/or immunizations. To track CD8 T-cell responses during infection, a surrogate-activation-marker approach … Read more

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