inmunoadmin

Gut microbiota regulates intestinal goblet cell response and mucin production by influencing the TLR2-SPDEF axis in an enteric parasitic infection. Yeganeh Yousefi

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Mucosal Immunol. 2025 Mar 29:S1933-0219(25)00033-9. doi: 10.1016/j.mucimm.2025.03.007. Online ahead of print. ABSTRACT Alterations in goblet cell biology constitute one of the most effective host responses against enteric parasites. In the gastrointestinal (GI) tract, millions of bacteria influence these goblet cell responses by binding to pattern recognition receptors such as toll-like receptors (TLRs). Studies suggest that … Read more

Regulation of respiratory CD8+ T-cell immunity by suppressive monocyte-like dendritic cells (MCs)

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J Immunol. 2025 Mar 31:vkae059. doi: 10.1093/jimmun/vkae059. Online ahead of print. ABSTRACT Active immune suppression can mediate the balance between protective cellular immunity and harmful immunopathology. This suppression can occur locally, at an infection site, or in regional draining lymph nodes (dLNs). Immune regulation is of particular importance in sites such as the lung where … Read more

Discovery of a new anti-γc antibody in clinical development for the treatment of autoimmune diseases

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J Immunol. 2025 Mar 12:vkae020. doi: 10.1093/jimmun/vkae020. Online ahead of print. ABSTRACT Autoimmune disease refers to a condition when the immune system anomalously attacks its own body and healthy cells. Although the exact causes of autoimmune diseases are unknown, it is recognized that excessive or aberrant cytokine responses contribute significantly to the development of autoimmunity. … Read more

Chronological maturation of the skin immune barrier is topographically different. Anikó Kapitány

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Mucosal Immunol. 2025 Mar 28:S1933-0219(25)00030-3. doi: 10.1016/j.mucimm.2025.03.004. Online ahead of print. ABSTRACT Adult skin varies across regions, with differences in chemical, physical, microbiota, and immune barriers. However, data on topographical immune differences in other age groups are limited. This study aimed to explore the chronological maturation of the immune barrier in various skin regions. A … Read more

Single-cell sequencing reveals the same heterogeneity of neutrophils in heatstroke-induced lung and liver injury. Fuquan Wang

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Mucosal Immunol. 2025 Mar 28:S1933-0219(25)00031-5. doi: 10.1016/j.mucimm.2025.03.005. Online ahead of print. ABSTRACT Heatstroke (HS) is typically considered a sepsis-like syndrome caused by hyperthermia, often accompanied by multiple organ dysfunctions (MODS). To explore the mechanisms of MODS, we established a mouse model of HS by exposing mice to a hyperthermic and high-humidity environment. Then, we utilized … Read more

Variable domain glycosylation as a marker and modulator of immune responses: Insights into autoimmunity and B-cell malignancies. Roxane Biersteker

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Semin Immunol. 2025 Mar 29;78:101946. doi: 10.1016/j.smim.2025.101946. Online ahead of print. ABSTRACT Glycosylation of antibodies is essential for shaping immune responses, as it contributes significantly to antibody function and diversity. While immunoglobulin G (IgG) Fc glycosylation is well-characterized, variable domain glycosylation (VDG) introduces an additional and less understood layer of complexity. Notably, VDG is associated … Read more

Interferon regulatory factor 3 beyond innate immunity: Regulation in obesity and metabolic disorders. Heng Li

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Semin Immunol. 2025 Mar 28;78:101948. doi: 10.1016/j.smim.2025.101948. Online ahead of print. ABSTRACT Interferon regulatory factor 3 (IRF3) is a transcription factor known primarily for its role in antiviral immunity via regulation of type I interferons (IFNs). Recent research has broadened its significance to encompass metabolic disorders, particularly obesity and diabetes. Obesity is characterized by chronic … Read more

Enhancing activity of FcαRI-bispecific antibodies using glycoengineering

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J Immunol. 2025 Mar 28:vkaf027. doi: 10.1093/jimmun/vkaf027. Online ahead of print. ABSTRACT Macrophages and natural killer (NK) cells can effectively kill tumor cells in the presence of anti-cancer IgG monoclonal antibodies (mAbs), but neutrophils are less effective. We previously showed that IgG1 bispecific antibodies (BsAb), which target the IgA Fc receptor (FcαRI, CD89) and a … Read more

Cryptococcosis, tuberculosis, and a kidney cancer fail to fit the atherosclerosis paradigm for foam cell lipid content

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J Immunol. 2025 Mar 28:vkaf038. doi: 10.1093/jimmun/vkaf038. Online ahead of print. ABSTRACT Foam cells are dysfunctional, lipid-laden macrophages associated with chronic inflammation of diverse origin. The long-standing paradigm that foam cells are cholesterol-laden derives from atherosclerosis research. We previously showed that, in tuberculosis, foam cells surprisingly accumulate triglycerides. Here, we utilized bacterial (Mycobacterium tuberculosis), fungal … Read more

Temporal Immune Profiling in the CSF and Blood of Patients with Aneurysmal Subarachnoid Hemorrhage​Thomas A Ujas on 28 de March de 2025 at 10:00

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J Leukoc Biol. 2025 Mar 28:qiaf038. doi: 10.1093/jleuko/qiaf038. Online ahead of print. ABSTRACT BACKGROUND: Delayed cerebral ischemia (DCI) is a significant complication of aneurysmal subarachnoid hemorrhage (aSAH). This study profiled immune responses after aSAH and evaluated their association with DCI onset. METHODS: Twelve aSAH patients were enrolled. Leukocyte populations and cytokine levels were analyzed in … Read more

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