inmunoadmin

Anti-CTLA4 therapy leads to early expansion of a peripheral Th17 population and induction of Th1 cytokines

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Cancer Immunol Res. 2025 Mar 27. doi: 10.1158/2326-6066.CIR-24-1055. Online ahead of print. ABSTRACT The systemic immunological effects of combining anti-CTLA4 therapy with PD-(L)1 blockade remain incompletely characterized, despite the widespread use of this combination in treating various solid tumors across multiple stages of disease. Herein, we investigated the additive impact of anti-CTLA4 on peripheral immune … Read more

Multi-Year Registry Study of Elapegademase Treatment in Patients With Adenosine Deaminase Severe Combined Immunodeficiency (ADA-SCID) Requiring Enzyme Replacement Therapy

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J Clin Immunol. 2025 Mar 27;45(1):84. doi: 10.1007/s10875-025-01873-3. ABSTRACT PURPOSE: The safety and tolerability of elapegademase (elapegademase-lvlr; Revcovi®) a PEGylated recombinant adenosine deaminase (ADA), were demonstrated in two Phase 3 clinical trials in the U.S. and Japan in patients with ADA-deficient severe combined immunodeficiency (ADA-SCID). Elapegademase replaced Adagen® (pegademase, a PEGylated bovine ADA) in 2018. … Read more

Diabetes can impact cellular immunity in solid tumors. Malgorzata A Garstka

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Trends Immunol. 2025 Mar 24:S1471-4906(25)00057-2. doi: 10.1016/j.it.2025.02.014. Online ahead of print. ABSTRACT Cancer is increasingly prevalent worldwide, often coexisting with type 2 diabetes (T2D). Recent breakthroughs reveal the immune system’s pivotal role in eliminating tumors and how the metabolic environment, such as glucose availability, affects antitumor immunity. Diabetes is known to dysregulate both innate and … Read more

Porphyromonas gingivalis outer membrane vesicles divert host innate immunity and promote inflammation via C4′ monophosphorylated lipid A

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J Immunol. 2025 Mar 12:vkae050. doi: 10.1093/jimmun/vkae050. Online ahead of print. ABSTRACT Porphyromonas gingivalis (Pg) is a prevalent pathogen that promotes human periodontal disease (PD) and exacerbates systemic comorbidities such as atherosclerosis, rheumatoid arthritis, and Alzheimer’s disease. Pg produces nonphosphorylated tetra-acylated lipid A (NPLA) in its outer membrane (OM) that evades host Toll-like receptor 4 … Read more

Mesenchymal stem cells and fibroblasts contribute to microvascular proliferation in glioblastoma and are correlated with immunosuppression and poor outcome

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Cancer Immunol Res. 2025 Mar 25. doi: 10.1158/2326-6066.CIR-24-0743. Online ahead of print. ABSTRACT Microvascular proliferation (MVP) is a disease-defining hallmark of glioblastoma (GBM) and other World Health Organization (WHO) grade 4 gliomas. MVP also serves as a poor prognostic marker in various solid tumors. Despite its clinical significance, the mechanisms and biological consequences of MVP … Read more

Combination therapy blocking TNF superfamily members 14 and 15 reverses pulmonary fibrosis

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J Immunol. 2025 Mar 24:vkaf002. doi: 10.1093/jimmun/vkaf002. Online ahead of print. ABSTRACT Currently, anti-inflammatory drugs fail to reduce pulmonary fibrosis and tissue remodeling in the clinic. Thus, there is an unmet need to develop novel antifibrotic drugs capable of reversing disease. Our lab has identified two novel mediators of pulmonary fibrosis belonging to the tumor … Read more

Peptide selectivity of killer cell immunoglobulin-like receptors differs with allotypic variation in HLA class I

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J Immunol. 2025 Mar 24:vkaf003. doi: 10.1093/jimmun/vkaf003. Online ahead of print. ABSTRACT Natural killer (NK) cell activation is regulated by killer cell immunoglobulin-like receptors (KIRs) that recognize human leukocyte antigen (HLA) class I molecules. While polymorphism in HLA can directly impact these interactions, the extent to which the HLA-associated peptide repertoire modulates NK cell function … Read more

Oxidative battles in tuberculosis: walking the ferroptotic tightrope. Mariana Araújo-Pereira

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Trends Immunol. 2025 Mar 22:S1471-4906(25)00052-3. doi: 10.1016/j.it.2025.02.009. Online ahead of print. ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains one of the leading causes of death worldwide. TB pathogenesis is shaped by a complex interaction between the pathogen and host immune responses, particularly through mechanisms such as oxidative stress and ferroptosis; a form of … Read more

Galectin-3 regulates erythropoiesis and enhances the immunoregulatory properties of CD71+ erythroid cells across developmental stages

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J Immunol. 2025 Mar 22:vkaf020. doi: 10.1093/jimmun/vkaf020. Online ahead of print. ABSTRACT Galectins are expressed by different immune and nonimmune cells with diverse immunomodulatory properties. However, their roles in erythropoiesis remain unknown. We investigated the expression of galectin genes in splenic CD71+ erythroid cells (CECs) from neonatal BALB/c mice at various developmental stages using bulk … Read more

High-salt diet drives depression-like behavior in mice by inducing IL-17A production

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J Immunol. 2025 Mar 22:vkaf019. doi: 10.1093/jimmun/vkaf019. Online ahead of print. ABSTRACT Major depression disorder is a common illness that severely limits psychosocial functioning, affects outcomes of other diseases, and diminishes the quality of life. High-salt diet (HSD) has long been closely associated with the occurrence and development of depression, but whether or how HSD … Read more

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